دورية أكاديمية
أعرض في EDS

Challenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors.

التفاصيل البيبلوغرافية
العنوان: Challenges, Advances and Opportunities in Exploring Natural Products to Control Arboviral Disease Vectors.
المؤلفون: Demarque DP; Laboratory of Pharmacognosy, Department of Pharmacy, Faculty of Health Sciences, University of Brasilia, Brasilia, Brazil.; Laboratory of Pharmacognosy, Department of Pharmacy, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Espindola LS; Laboratory of Pharmacognosy, Department of Pharmacy, Faculty of Health Sciences, University of Brasilia, Brasilia, Brazil.
المصدر: Frontiers in chemistry [Front Chem] 2021 Nov 15; Vol. 9, pp. 779049. Date of Electronic Publication: 2021 Nov 15 (Print Publication: 2021).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101627988 Publication Model: eCollection Cited Medium: Print ISSN: 2296-2646 (Print) Linking ISSN: 22962646 NLM ISO Abbreviation: Front Chem Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media S.A., [2013]-
مستخلص: Natural products constitute an important source of molecules for product development. However, despite numerous reports of compounds and active extracts from biodiversity, poor and developing countries continue to suffer with endemic diseases caused by arboviral vectors, including dengue, Zika, chikungunya and urban yellow fever. Vector control remains the most efficient disease prevention strategy. Wide and prolonged use of insecticides has resulted in vector resistance, making the search for new chemical prototypes imperative. Considering the potential of natural products chemistry for developing natural products-based products, including insecticides, this contribution discusses the general aspects and specific characteristics involved in the development of drug leads for vector control. Throughout this work, we highlight the obstacles that need to be overcome in order for natural products compounds to be considered promising prototypes. Moreover, we analyze the bottlenecks that should be addressed, together with potential strategies, to rationalize and improve the efficiency of the drug discovery process.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2021 Demarque and Espindola.)
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فهرسة مساهمة: Keywords: Aedes aegypti; arboviral vectors; dengue; drug discovery; insecticides; natural products
تواريخ الأحداث: Date Created: 20211206 Latest Revision: 20211207
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8634490
DOI: 10.3389/fchem.2021.779049
PMID: 34869227
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-2646
DOI:10.3389/fchem.2021.779049