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Toxicological and pharmacological effects of pentacyclic triterpenes rich fraction obtained from the leaves of Mansoa hirsuta.

التفاصيل البيبلوغرافية
العنوان: Toxicological and pharmacological effects of pentacyclic triterpenes rich fraction obtained from the leaves of Mansoa hirsuta.
المؤلفون: Pereira JR; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Natal, RN 59012-570, Brazil; Department of Chemistry and Exact, State University of Southwest of Bahia, Jequié, BA 45208-091, Brazil. Electronic address: joque.rodrigues@gmail.com., da Fonseca AG; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Natal, RN 59012-570, Brazil; Department of Chemistry and Exact, State University of Southwest of Bahia, Jequié, BA 45208-091, Brazil. Electronic address: aldilanefonseca@hotmail.com., de Sena Fernandes LL; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Natal, RN 59012-570, Brazil; Department of Chemistry and Exact, State University of Southwest of Bahia, Jequié, BA 45208-091, Brazil. Electronic address: luleiros@yahoo.com.br., Furtado AA; Department of Pharmacy, Laboratório Escola de Farmácia Industrial, Federal University of Rio Grande do Norte, Natal, RN 59012-570, Brazil; Department of Chemistry and Exact, State University of Southwest of Bahia, Jequié, BA 45208-091, Brazil. Electronic address: allannyfurtado@hotmail.com., da Silva VC; Department of Biophysics and Pharmacology, Centro de Biociências, Federal University of Rio Grande do Norte, Natal, RN 59078-570, Brazil; Department of Chemistry and Exact, State University of Southwest of Bahia, Jequié, BA 45208-091, Brazil. Electronic address: vcs.biomed@gmail.com., da Veiga Júnior VF; Chemical Engineering Department, Military Institute of Engineering, Rio de Janeiro, RJ 22290-270, Brazil; Department of Chemistry and Exact, State University of Southwest of Bahia, Jequié, BA 45208-091, Brazil. Electronic address: valdir.veiga@gmail.com., Sant'Ana AEG; Institute of Chemistry and Biotechnology, Federal University of Alagoas, Campus A.C. Simões, Maceió, AL 57072-970, Brazil; Department of Chemistry and Exact, State University of Southwest of Bahia, Jequié, BA 45208-091, Brazil. Electronic address: aegsal@gmail.com., Oliveira CN; Department of Pathology, Federal University of Rio Grande do Norte, Natal, RN 59012570, Brazil; Department of Chemistry and Exact, State University of Southwest of Bahia, Jequié, BA 45208-091, Brazil. Electronic address: cauca2311@gmail.com., Guerra GCB; Department of Biophysics and Pharmacology, Centro de Biociências, Federal University of Rio Grande do Norte, Natal, RN 59078-570, Brazil; Department of Chemistry and Exact, State University of Southwest of Bahia, Jequié, BA 45208-091, Brazil. Electronic address: gerlaneguerra@hotmail.com., de Freitas Fernandes-Pedrosa M; Department of Pharmacy, Laboratório Escola de Farmácia Industrial, Federal University of Rio Grande do Norte, Natal, RN 59012-570, Brazil; Department of Chemistry and Exact, State University of Southwest of Bahia, Jequié, BA 45208-091, Brazil. Electronic address: mffpedrosa@gmail.com., Gavioli EC; Department of Biophysics and Pharmacology, Centro de Biociências, Federal University of Rio Grande do Norte, Natal, RN 59078-570, Brazil; Department of Chemistry and Exact, State University of Southwest of Bahia, Jequié, BA 45208-091, Brazil., Oliveira-Costa JF; State Health Secretary, Pharmaceutical Assistance Directory, Salvador, Bahia 41233-015, Brazil; Department of Chemistry and Exact, State University of Southwest of Bahia, Jequié, BA 45208-091, Brazil. Electronic address: josefernandocosta@hotmail.com., Soares MBP; State Health Secretary, Pharmaceutical Assistance Directory, Salvador, Bahia 41233-015, Brazil; Department of Chemistry and Exact, State University of Southwest of Bahia, Jequié, BA 45208-091, Brazil. Electronic address: milena.soares@fiocruz.br., de Lima ÁAN; Department of Pharmacy, Laboratório Escola de Farmácia Industrial, Federal University of Rio Grande do Norte, Natal, RN 59012-570, Brazil; Department of Chemistry and Exact, State University of Southwest of Bahia, Jequié, BA 45208-091, Brazil. Electronic address: adleyantonini@yahoo.com.br., de Melo Silva D; Gonçalo Moniz Center, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, Bahia 40296-710, Brazil; Department of Chemistry and Exact, State University of Southwest of Bahia, Jequié, BA 45208-091, Brazil. Electronic address: daniel.melo@uesb.edu.br., Moura Lemos TMA; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Natal, RN 59012-570, Brazil; Department of Chemistry and Exact, State University of Southwest of Bahia, Jequié, BA 45208-091, Brazil. Electronic address: telmaml@yahoo.com.br.
المصدر: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Jan; Vol. 145, pp. 112478. Date of Electronic Publication: 2021 Dec 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
أسماء مطبوعة: Publication: Paris : Editions Scientifiques Elsevier
Original Publication: New York, N.Y. : Masson Pub. USA, Inc., c1982-
مواضيع طبية MeSH: Tissue Distribution*, Behavior, Animal/*drug effects , Bignoniaceae/*chemistry , Pentacyclic Triterpenes/*pharmacology, Analgesics/pharmacology ; Animals ; Anti-Inflammatory Agents/pharmacology ; Brazil ; Cell Survival/drug effects ; Cells, Cultured ; Disease Models, Animal ; Mice ; Plant Extracts/pharmacology ; Plant Leaves ; Plants, Medicinal ; Toxicity Tests/methods ; Toxicity Tests/statistics & numerical data
مستخلص: Mansoa hirsuta is a medicinal plant native to the Brazilian semi-arid region. This approach aimed to investigate the in vitro and in vivo toxicity and anti-inflammatory and analgesic actions of the M. hirsuta fraction (MHF). In vitro cell viability was assessed in 3T3 cells. In vivo, the acute toxicity test, a single dose of the MHF was administered. For the subchronic toxicity test, three doses of were administered for 30 days. Locomotion and motor coordination were assessed using open field and rota-rod. The anti-inflammatory activity was evaluated in carrageenan-induced paw edema and zymosan-induced air-pouch models. Myeloperoxidase (MPO) and total proteins were also measured. The antinociceptive activity MHF was determined using acid acetic-induced abdominal writhing and formalin models. In the cytotoxicity assay, MHF showed no significative impairment of cell viability and in the acute toxicity study, did not cause mortality or signs of toxicity. Repeated exposure to MHF did not cause relevant toxicological changes. The evaluation in the open field test showed that the MHF did not alter the locomotor activity and there was no change in motor coordination and balance of animals. MHF significantly reduced edema, MPO production, the migration of leukocytes and protein leakage. In addition, MHF reduced abdominal writhing and significantly inhibited the first and second stage of the formalin test. The results of this study indicated that MHF has an anti-inflammatory and analgesic potential without causing acute or subchronic toxic effects and it can be a promising natural source to be explored.
(Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
فهرسة مساهمة: Keywords: Acute toxicity; Analgesia; Inflammation; Mansoa hirsuta; Subchronic toxicity
المشرفين على المادة: 0 (Analgesics)
0 (Anti-Inflammatory Agents)
0 (Pentacyclic Triterpenes)
0 (Plant Extracts)
تواريخ الأحداث: Date Created: 20211207 Date Completed: 20220309 Latest Revision: 20220309
رمز التحديث: 20240628
DOI: 10.1016/j.biopha.2021.112478
PMID: 34872801
قاعدة البيانات: MEDLINE
الوصف
تدمد:1950-6007
DOI:10.1016/j.biopha.2021.112478