دورية أكاديمية
Mechanisms of epigenetic regulation by C. elegans nuclear RNA interference pathways.
| العنوان: | Mechanisms of epigenetic regulation by C. elegans nuclear RNA interference pathways. |
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| المؤلفون: | Seroussi U; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Li C; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada., Sundby AE; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Lee TL; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada., Claycomb JM; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Electronic address: julie.claycomb@utoronto.ca., Saltzman AL; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada. Electronic address: arneet.saltzman@utoronto.ca. |
| المصدر: | Seminars in cell & developmental biology [Semin Cell Dev Biol] 2022 Jul; Vol. 127, pp. 142-154. Date of Electronic Publication: 2021 Dec 06. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: England NLM ID: 9607332 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-3634 (Electronic) Linking ISSN: 10849521 NLM ISO Abbreviation: Semin Cell Dev Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Academic Press Original Publication: London, UK : Academic Press, c1996- |
| مواضيع طبية MeSH: | Caenorhabditis elegans Proteins*/genetics , Caenorhabditis elegans Proteins*/metabolism , RNA, Small Untranslated*/metabolism, Animals ; Argonaute Proteins/genetics ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Epigenesis, Genetic/genetics ; RNA Interference ; RNA, Small Interfering/genetics |
| مستخلص: | RNA interference (RNAi) is a highly conserved gene regulatory phenomenon whereby Argonaute/small RNA (AGO/sRNA) complexes target transcripts by antisense complementarity to modulate gene expression. While initially appreciated as a cytoplasmic process, RNAi can also occur in the nucleus where AGO/sRNA complexes are recruited to nascent transcripts. Nuclear AGO/sRNA complexes recruit co-factors that regulate transcription by inhibiting RNA Polymerase II, modifying histones, compacting chromatin and, in some organisms, methylating DNA. C. elegans has a longstanding history in unveiling the mechanisms of RNAi and has become an outstanding model to delineate the mechanisms underlying nuclear RNAi. In this review we highlight recent discoveries in the field of nuclear RNAi in C. elegans and the roles of nuclear RNAi in the regulation of gene expression, chromatin organization, genome stability, and transgenerational epigenetic inheritance. (Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| معلومات مُعتمدة: | PJT-156083 Canada CIHR; PJG-175378 Canada CIHR; PJT-175245 Canada CIHR |
| فهرسة مساهمة: | Keywords: Argonaute; Chromatin modification; Epigenetic inheritance; Nuclear RNAi; Small RNA; Transcriptional gene silencing |
| المشرفين على المادة: | 0 (Argonaute Proteins) 0 (Caenorhabditis elegans Proteins) 0 (RNA, Small Interfering) 0 (RNA, Small Untranslated) |
| تواريخ الأحداث: | Date Created: 20211208 Date Completed: 20220608 Latest Revision: 20220825 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.semcdb.2021.11.018 |
| PMID: | 34876343 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1096-3634 |
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| DOI: | 10.1016/j.semcdb.2021.11.018 |