دورية أكاديمية
Feasibility of sonothrombolysis in the ambulance for ST-elevation myocardial infarction.
| العنوان: | Feasibility of sonothrombolysis in the ambulance for ST-elevation myocardial infarction. |
|---|---|
| المؤلفون: | El Kadi S; Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. s.elkadi@amsterdamumc.nl., Porter TR; Division of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, NE, USA., Zanstra M; Ambulance Amsterdam, Zaanstreek-Waterland, Zaandam, The Netherlands., Siegers A; Ambulance Amsterdam, Zaanstreek-Waterland, Zaandam, The Netherlands., van Loon RB; Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands., Hopman LHGA; Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands., van Rossum AC; Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands., Kamp O; Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. |
| المصدر: | The international journal of cardiovascular imaging [Int J Cardiovasc Imaging] 2022 May; Vol. 38 (5), pp. 1089-1098. Date of Electronic Publication: 2021 Dec 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 100969716 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8312 (Electronic) Linking ISSN: 15695794 NLM ISO Abbreviation: Int J Cardiovasc Imaging Subsets: PubMed not MEDLINE; MEDLINE |
| أسماء مطبوعة: | Publication: [New York] : Springer Original Publication: Boston : Kluwer Academic Publishers, c2001- |
| مستخلص: | Patients with ST-elevation myocardial infarction (STEMI) due to coronary occlusion require immediate restoration of epicardial and microvascular blood flow. A potentially new reperfusion method is the use of ultrasound and microbubbles, also called sonothrombolysis. The oscillation and collapse of intravenously administered microbubbles upon exposure to high mechanical index (MI) ultrasound pulses results in thrombus dissolution and stimulates nitric oxide-mediated increases in tissue perfusion. The aim of this study was to assess feasibility of sonothrombolysis in the ambulance for STEMI patients. Patients presenting with chest pain and ST-elevations on initial electrocardiogram were included. Sonothrombolysis was applied in the ambulance during patient transfer to the percutaneous coronary intervention (PCI) center. Feasibility was assessed based on duration of sonothrombolysis treatment and number of high MI pulses applied. Vital parameters, ST-resolution, pre- and post-PCI coronary flow and cardiovascular magnetic resonance images were analyzed. Follow up was performed at six months after STEMI. Twelve patients were screened, of which three patients were included in the study. Sonothrombolysis duration and number of high MI pulses ranged between 12 and 17 min and 32-60 flashes respectively. No arrhythmias or changes in vital parameters were observed during and directly after sonothrombolysis, although one patient developed in-hospital ventricular fibrillation 20 min after sonothrombolysis completion but before PCI. In one case, sonothrombolysis on top of regular pre-hospital care resulted in reperfusion before PCI. This is the first report on the feasibility of performing sonothrombolysis to treat myocardial infarction in an ambulance. To assess efficacy and safety of pre-hospital sonothrombolysis, clinical trials with greater patient numbers should be performed. EU Clinical Trials Register (identifier: 2019-001883-31), registered 2020-02-25. (© 2021. The Author(s), under exclusive licence to Springer Nature B.V.) |
| References: | Slikkerveer J, Juffermans LJ, van Royen N, Appelman Y, Porter TR, Kamp O (2019) Therapeutic application of contrast ultrasound in ST elevation myocardial infarction: role in coronary thrombosis and microvascular obstruction. Eur Heart J Acute Cardiovasc Care 8(1):45–53. (PMID: 10.1177/204887261772855928868906) Bader KB, Bouchoux G, Holland CK (2016) Sonothrombolysis. Adv Exp Med Biol 880:339–362. (PMID: 10.1007/978-3-319-22536-4_19264863474933511) Belcik JT, Davidson BP, Xie A, Wu MD, Yadava M, Qi Y, Liang S, Chon CR, Ammi AY, Field J, Harmann L, Chilian WM, Linden J, Lindner JR (2017) Augmentation of muscle blood flow by ultrasound cavitation Is mediated by ATP and purinergic signaling. Circulation 135(13):1240–1252. (PMID: 10.1161/CIRCULATIONAHA.116.024826281741915373943) Slikkerveer J, Kleijn SA, Appelman Y, Porter TR, Veen G, van Rossum AC, Kamp O (2012) Ultrasound enhanced prehospital thrombolysis using microbubbles infusion in patients with acute ST elevation myocardial infarction: pilot of the Sonolysis study. Ultrasound Med Biol 38(2):247–252. (PMID: 10.1016/j.ultrasmedbio.2011.11.00122178160) Mathias W Jr, Tsutsui JM, Tavares BG, Fava AM, Aguiar MOD, Borges BC, Oliveira MT Jr, Soeiro A, Nicolau JC, Ribeiro HB, Chiang HP, Sbano JCN, Morad A, Goldsweig A, Rochitte CE, Lopes BBC, Ramirez JAF, Kalil Filho R, Porter TR, Investigators M (2019) Sonothrombolysis in ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. J Am Coll Cardiol 73(22):2832–2842. (PMID: 10.1016/j.jacc.2019.03.00630894317) El Kadi S, Porter TR, van Rossum AC, Kamp O (2021) Sonothrombolysis in the ambulance for ST-elevation myocardial infarction: rationale and protocol. Neth Heart J 29(6):330–337. (PMID: 10.1007/s12471-020-01516-933184756) Nederhoed JH, Ebben HP, Slikkerveer J, Hoksbergen AWJ, Kamp O, Tangelder GJ, Wisselink W, Musters RJP, Yeung KK (2017) Intravenous targeted microbubbles carrying urokinase versus urokinase alone in acute peripheral arterial thrombosis in a porcine model. Ann Vasc Surg 44:400–407. (PMID: 10.1016/j.avsg.2017.05.01128546045) Lindner JR, Song J, Christiansen J, Klibanov AL, Xu F, Ley K (2001) Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation 104(17):2107–2112. (PMID: 10.1161/hc4201.09706111673354) Davidson BP, Hodovan J, Layoun ME, Golwala H, Zahr F, Lindner JR (2021) Echocardiographic ischemic memory molecular imaging for point-of-care detection of myocardial ischemia. J Am Coll Cardiol 78(20):1990–2000. (PMID: 10.1016/j.jacc.2021.08.068347637768597917) Mott B, Packwood W, Xie A, Belcik JT, Taylor RP, Zhao Y, Davidson BP, Lindner JR (2016) Echocardiographic ischemic memory imaging through complement-mediated vascular adhesion of phosphatidylserine-containing microbubbles. JACC Cardiovasc Imaging 9(8):937–946. (PMID: 10.1016/j.jcmg.2015.11.03127318722) |
| فهرسة مساهمة: | Keywords: Ambulance; Reperfusion; ST-elevation myocardial infarction; Sonothrombolysis; Therapy |
| تواريخ الأحداث: | Date Created: 20211208 Latest Revision: 20240531 |
| رمز التحديث: | 20240531 |
| DOI: | 10.1007/s10554-021-02487-7 |
| PMID: | 34877619 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1875-8312 |
|---|---|
| DOI: | 10.1007/s10554-021-02487-7 |