دورية أكاديمية
أعرض في EDS

Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries.

التفاصيل البيبلوغرافية
العنوان: Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries.
المؤلفون: Olivera GC; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden., Ross EC; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden., Peuckert C; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden., Barragan A; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
المصدر: ELife [Elife] 2021 Dec 08; Vol. 10. Date of Electronic Publication: 2021 Dec 08.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Blood-Brain Barrier/*parasitology , Capillaries/*physiology , Toxoplasma/*physiology , Toxoplasmosis, Cerebral/*parasitology, Animals ; Brain/parasitology ; Female ; Male ; Mice ; Parasite Load ; Permeability
مستخلص: The cellular barriers of the central nervous system proficiently protect the brain parenchyma from infectious insults. Yet, the single-celled parasite Toxoplasma gondii commonly causes latent cerebral infection in humans and other vertebrates. Here, we addressed the role of the cerebral vasculature in the passage of T. gondii to the brain parenchyma. Shortly after inoculation in mice, parasites mainly localized to cortical capillaries, in preference over post-capillary venules, cortical arterioles or meningeal and choroidal vessels. Early invasion to the parenchyma (days 1-5) occurred in absence of a measurable increase in blood-brain barrier (BBB) permeability, perivascular leukocyte cuffs or hemorrhage. However, sparse focalized permeability elevations were detected adjacently to replicative parasite foci. Further, T. gondii triggered inflammatory responses in cortical microvessels and endothelium. Pro- and anti-inflammatory treatments of mice with LPS and hydrocortisone, respectively, impacted BBB permeability and parasite loads in the brain parenchyma. Finally, pharmacological inhibition or Cre/ lox P conditional knockout of endothelial focal adhesion kinase (FAK), a BBB intercellular junction regulator, facilitated parasite translocation to the brain parenchyma. The data reveal that the initial passage of T. gondii to the central nervous system occurs principally across cortical capillaries. The integrity of the microvascular BBB restricts parasite transit, which conversely is exacerbated by the inflammatory response.
Competing Interests: GO, ER, CP, AB No competing interests declared
(© 2021, Olivera et al.)
References: Cell Microbiol. 2005 Apr;7(4):561-8. (PMID: 15760456)
Cancer Sci. 2020 Sep;111(9):3142-3154. (PMID: 32536012)
Nat Rev Neurosci. 2006 Jan;7(1):41-53. (PMID: 16371949)
Immunity. 2017 Jun 20;46(6):891-909. (PMID: 28636958)
Front Immunol. 2019 Feb 14;10:242. (PMID: 30873157)
Microbes Infect. 2007 Sep;9(11):1291-8. (PMID: 17897859)
Lancet. 2004 Jun 12;363(9425):1965-76. (PMID: 15194258)
Cell Microbiol. 2014 Apr;16(4):580-95. (PMID: 24245749)
Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9298-303. (PMID: 19470647)
J Neuroimmunol. 2011 Mar;232(1-2):119-30. (PMID: 21106256)
Trends Immunol. 2017 Aug;38(8):606-615. (PMID: 28559148)
Nature. 1995 Oct 12;377(6549):539-44. (PMID: 7566154)
Acta Neuropathol. 2016 Feb;131(2):185-209. (PMID: 26744349)
Am J Pathol. 2018 Nov;188(11):2674-2687. (PMID: 30121257)
J Neurovirol. 2009 Jul;15(4):312-23. (PMID: 19521898)
J Cell Biol. 2005 Jun 20;169(6):941-52. (PMID: 15967814)
Cancer Biol Ther. 2018 Apr 3;19(4):316-327. (PMID: 29303405)
Nature. 2010 Nov 25;468(7323):557-61. (PMID: 20944627)
J Med Microbiol. 2010 Jun;59(Pt 6):641-647. (PMID: 20150319)
Infect Immun. 2011 Aug;79(8):3046-52. (PMID: 21628522)
Curr Neuropharmacol. 2008 Sep;6(3):179-92. (PMID: 19506719)
Cell Mol Life Sci. 2021 Jun;78(12):5197-5212. (PMID: 34023934)
J Immunother Cancer. 2019 Aug 22;7(1):224. (PMID: 31439034)
J Eukaryot Microbiol. 1997 Nov-Dec;44(6):592-602. (PMID: 9435131)
Front Cell Neurosci. 2015 Mar 12;9:80. (PMID: 25814932)
J Neurosci Res. 1988 Sep;21(1):56-61. (PMID: 3216412)
PLoS Pathog. 2017 Oct 16;13(10):e1006671. (PMID: 29036202)
Cell. 1996 Mar 22;84(6):933-9. (PMID: 8601316)
Nature. 2002 Feb 21;415(6874):926-9. (PMID: 11859373)
J Biol Chem. 2018 Mar 2;293(9):3374-3385. (PMID: 29295815)
Exp Parasitol. 1998 Sep;90(1):86-94. (PMID: 9709034)
Trends Microbiol. 2012 Jun;20(6):282-90. (PMID: 22564250)
J Cereb Blood Flow Metab. 2017 Jan;37(1):52-68. (PMID: 27780904)
PLoS Pathog. 2012;8(12):e1003051. (PMID: 23236276)
Trends Mol Med. 2014 Oct;20(10):571-8. (PMID: 25178566)
Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24796-24807. (PMID: 31727842)
Mol Biochem Parasitol. 2001 Apr 6;113(2):309-13. (PMID: 11295185)
Sci Rep. 2017 Jul 18;7(1):5675. (PMID: 28720868)
Immunol Cell Biol. 2012 Oct;90(9):912-5. (PMID: 22525368)
Tissue Barriers. 2016 Jan 28;4(1):e1143544. (PMID: 27141424)
Int J Parasitol. 2009 Oct;39(12):1385-94. (PMID: 19433092)
Nat Rev Microbiol. 2021 Jul;19(7):467-480. (PMID: 33627834)
Virulence. 2012 Mar-Apr;3(2):182-92. (PMID: 22460645)
Cell Microbiol. 2018 Mar;20(3):. (PMID: 29119662)
Cold Spring Harb Perspect Biol. 2015 Jan 05;7(1):a020412. (PMID: 25561720)
PLoS Pathog. 2017 Dec 7;13(12):e1006739. (PMID: 29216332)
Exp Parasitol. 1991 Nov;73(4):460-8. (PMID: 1959573)
Nat Microbiol. 2016 Feb 15;1:16001. (PMID: 27572166)
Lung Cancer. 2020 Jan;139:60-67. (PMID: 31739184)
Blood. 2006 Jan 1;107(1):309-16. (PMID: 16051744)
Nat Protoc. 2015 Dec;10(12):2016-26. (PMID: 26562622)
J Exp Med. 2002 Jun 17;195(12):1625-33. (PMID: 12070289)
J Immunol. 2015 Nov 15;195(10):4999-5010. (PMID: 26466961)
Microbes Infect. 2015 Oct;17(10):698-709. (PMID: 26183539)
J Clin Invest. 2004 Sep;114(5):689-94. (PMID: 15343387)
Nat Microbiol. 2019 Nov;4(11):1951-1963. (PMID: 31332383)
J Immunol. 2001 Oct 15;167(8):4574-84. (PMID: 11591786)
Cell Microbiol. 2019 Sep;21(9):e13048. (PMID: 31099453)
Brain Res. 2001 Mar 30;896(1-2):36-42. (PMID: 11277970)
J Cell Biol. 2008 Apr 7;181(1):43-50. (PMID: 18391070)
Elife. 2020 Nov 12;9:. (PMID: 33179597)
Cancer Res. 2010 Dec 15;70(24):10131-40. (PMID: 21159635)
Clin Microbiol Rev. 2014 Oct;27(4):691-726. (PMID: 25278572)
PLoS Pathog. 2011 Sep;7(9):e1002246. (PMID: 21949652)
Cell Microbiol. 2010 Mar;12(3):292-300. (PMID: 19995386)
Nat Commun. 2019 Dec 20;10(1):5816. (PMID: 31862977)
J Neurosci Methods. 2011 Feb 15;195(2):206-10. (PMID: 21168441)
Annu Rev Pathol. 2007;2:217-49. (PMID: 18039099)
PLoS Pathog. 2014 Dec 04;10(12):e1004528. (PMID: 25474413)
Nat Rev Microbiol. 2017 Mar;15(3):149-159. (PMID: 28090076)
Acta Pharm Sin B. 2020 Jun;10(6):987-1003. (PMID: 32642407)
J Neuroinflammation. 2015 Nov 25;12:223. (PMID: 26608623)
Biochim Biophys Acta. 2013 Jan;1832(1):151-9. (PMID: 23064287)
Cell Host Microbe. 2019 Oct 9;26(4):478-492.e8. (PMID: 31600500)
J Cell Sci. 2019 Feb 25;132(5):. (PMID: 30804085)
فهرسة مساهمة: Keywords: CNS infection; Toxoplasma gondii; apicomplexa; biological barriers; blood-brain barrier; immunology; infectious disease; inflammation; microbiology; mouse
تواريخ الأحداث: Date Created: 20211208 Date Completed: 20220125 Latest Revision: 20220125
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8700292
DOI: 10.7554/eLife.69182
PMID: 34877929
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.69182