دورية أكاديمية
Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal.
| العنوان: | Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal. |
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| المؤلفون: | Ahouidi AD; Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal. ambroise.ahouidi@iressef.org., Rodgers MA; Abbott Global Surveillance Program, Abbott Laboratories, Abbott Park, IL, USA. mary.rodgers@abbott.com., Padane A; Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal., Leye N; Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal., Olivo A; Abbott Global Surveillance Program, Abbott Laboratories, Abbott Park, IL, USA., Mbow M; Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal., Mboup A; Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal., Diaw PA; Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal., Dia A; Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal., Harris B; Abbott Global Surveillance Program, Abbott Laboratories, Abbott Park, IL, USA., Padane YAD; Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal., Lo G; Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal., Meyer TV; Abbott Global Surveillance Program, Abbott Laboratories, Abbott Park, IL, USA., Diedhiou CK; Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal., Diagne D; Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal., Kane NCT; Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal., Cloherty G; Abbott Global Surveillance Program, Abbott Laboratories, Abbott Park, IL, USA., Mboup S; Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal. |
| المصدر: | Scientific reports [Sci Rep] 2021 Dec 08; Vol. 11 (1), pp. 23644. Date of Electronic Publication: 2021 Dec 08. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
| مواضيع طبية MeSH: | COVID-19/*pathology , SARS-CoV-2/*metabolism , Spike Glycoprotein, Coronavirus/*genetics, COVID-19/virology ; Humans ; Mutation ; Protein Binding ; Protein Domains/genetics ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Senegal ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/metabolism |
| مستخلص: | The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages that carry mutations in the spike gene are of concern for potential impact to treatment and prevention efforts. To monitor for new SARS-CoV-2 mutations, a panel of specimens were sequenced from both wave one (N = 96), and wave two (N = 117) of the pandemic in Senegal by whole genome next generation sequencing. Amongst these genomes, new combinations of SARS-CoV-2 spike mutations were identified, with E484K + N501T, L452R + N501Y, and L452M + S477N exclusively found in second wave specimens. These sequences are evidence of local diversification over the course of the pandemic and parallel evolution of escape mutations in different lineages. (© 2021. The Author(s).) |
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| المشرفين على المادة: | 0 (Spike Glycoprotein, Coronavirus) 0 (spike protein, SARS-CoV-2) |
| SCR Organism: | SARS-CoV-2 variants |
| تواريخ الأحداث: | Date Created: 20211209 Date Completed: 20211215 Latest Revision: 20231108 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC8655062 |
| DOI: | 10.1038/s41598-021-02874-z |
| PMID: | 34880295 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2045-2322 |
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| DOI: | 10.1038/s41598-021-02874-z |