دورية أكاديمية
أعرض في EDS

The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivation.

التفاصيل البيبلوغرافية
العنوان: The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivation.
المؤلفون: Raposo AC; Departamento de Bioengenharia e Instituto de Bioengenharia e Biociências, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.; Associate Laboratory i4HB - Institute for Health and Bioeconomy, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Casanova M; Departamento de Bioengenharia e Instituto de Bioengenharia e Biociências, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.; Associate Laboratory i4HB - Institute for Health and Bioeconomy, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Gendrel AV; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., da Rocha ST; Departamento de Bioengenharia e Instituto de Bioengenharia e Biociências, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.; Associate Laboratory i4HB - Institute for Health and Bioeconomy, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
المصدر: Biochemical Society transactions [Biochem Soc Trans] 2021 Dec 17; Vol. 49 (6), pp. 2549-2560.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Portland Press On The Behalf Of The Biochemical Society Country of Publication: England NLM ID: 7506897 Publication Model: Print Cited Medium: Internet ISSN: 1470-8752 (Electronic) Linking ISSN: 03005127 NLM ISO Abbreviation: Biochem Soc Trans Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Portland Press On The Behalf Of The Biochemical Society
مواضيع طبية MeSH: Tandem Repeat Sequences*, RNA, Long Noncoding/*genetics, Animals ; Gene Silencing ; Humans ; Mice ; Polycomb-Group Proteins/metabolism ; Transcription, Genetic ; X Chromosome Inactivation
مستخلص: X-inactive-specific transcript (Xist) is a long non-coding RNA (lncRNA) essential for X-chromosome inactivation (XCI) in female placental mammals. Thirty years after its discovery, it is still puzzling how this lncRNA triggers major structural and transcriptional changes leading to the stable silencing of an entire chromosome. Recently, a series of studies in mouse cells have uncovered domains of functional specialization within Xist mapping to conserved tandem repeat regions, known as Repeats A-to-F. These functional domains interact with various RNA binding proteins (RBPs) and fold into distinct RNA structures to execute specific tasks in a synergistic and coordinated manner during the inactivation process. This modular organization of Xist is mostly conserved in humans, but recent data point towards differences regarding functional specialization of the tandem repeats between the two species. In this review, we summarize the recent progress on understanding the role of Xist repetitive blocks and their involvement in the molecular mechanisms underlying XCI. We also discuss these findings in the light of the similarities and differences between mouse and human Xist.
(© 2021 The Author(s).)
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فهرسة مساهمة: Keywords: X-chromosome inactivation; chromatin; epigenetics; lncRNA; tandem repeat
المشرفين على المادة: 0 (Polycomb-Group Proteins)
0 (RNA, Long Noncoding)
0 (XIST non-coding RNA)
تواريخ الأحداث: Date Created: 20211209 Date Completed: 20220401 Latest Revision: 20240821
رمز التحديث: 20240821
مُعرف محوري في PubMed: PMC8786293
DOI: 10.1042/BST20210253
PMID: 34882219
قاعدة البيانات: MEDLINE
الوصف
تدمد:1470-8752
DOI:10.1042/BST20210253