دورية أكاديمية
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The Effects of Vitamin D on the Expression of IL-33 and Its Receptor ST2 in Skin Cells; Potential Implication for Psoriasis.

التفاصيل البيبلوغرافية
العنوان: The Effects of Vitamin D on the Expression of IL-33 and Its Receptor ST2 in Skin Cells; Potential Implication for Psoriasis.
المؤلفون: Wierzbicka JM; Histology Department, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, Poland., Piotrowska A; Histology Department, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, Poland., Purzycka-Bohdan D; Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland., Olszewska A; Histology Department, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, Poland., Nowak JI; Histology Department, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, Poland., Szczerkowska-Dobosz A; Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland., Nedoszytko B; Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland.; Invicta Fertility and Reproductive Centre, Molecular Laboratory, 80-850 Gdansk, Poland., Nowicki RJ; Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland., Żmijewski MA; Histology Department, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, Poland.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2021 Nov 29; Vol. 22 (23). Date of Electronic Publication: 2021 Nov 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Interleukin-1 Receptor-Like 1 Protein/*metabolism , Interleukin-33/*metabolism , Keratinocytes/*drug effects , Psoriasis/*drug therapy , Skin/*drug effects , Vitamin D/*pharmacology, Adolescent ; Case-Control Studies ; Humans ; Interleukin-1 Receptor-Like 1 Protein/genetics ; Interleukin-33/genetics ; Keratinocytes/metabolism ; Psoriasis/metabolism ; Psoriasis/pathology ; Skin/metabolism ; Vitamins/pharmacology
مستخلص: Interleukin 33 (IL-33) belongs to the IL-1 family and is produced constitutively by epithelial and endothelial cells of various organs, such as the skin. It takes part in the maintenance of tissue homeostasis, repair, and immune response, including activation of Th2 lymphocytes. Its involvement in pathogenesis of several inflammatory diseases including psoriasis was also suggested, but this is not fully understood. The aim of the study was to investigate expression of IL-33 and its receptor, ST2, in psoriasis, and the effects of the active form of vitamin D (1,25(OH) 2 D 3 ) on their expression in skin cells. Here we examined mRNA and protein profiles of IL-33 and ST2 in 18 psoriatic patients and healthy volunteers by qPCR and immunostaining techniques. Potential effects of 1,25(OH) 2 D 3 and its receptor (VDR) on the expression of IL-33 and ST2 were tested in cultured keratinocytes, melanocytes, fibroblasts, and basal cell carcinoma cells. It was shown that 1,25(OH) 2 D 3 effectively stimulated expression of IL-33 and its receptor ST2's mRNAs in a time-dependent manner, in keratinocytes and to the lesser extends in melanocytes, but not in fibroblasts. Furthermore, the effect of vitamin D on expression of IL-33 and ST2 was VDR-dependent. Finally, we demonstrated that the expression of mRNA for IL-33 was mainly elevated in the psoriatic skin but not in its margin. Interestingly, ST2 mRNA was downregulated in psoriatic lesion compared to both marginal tissue as well as healthy skin. Our data indicated that vitamin D can modulate IL-33 signaling, opening up new perspectives for our understanding of the mechanism of vitamin D action in psoriasis therapy.
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معلومات مُعتمدة: 2017/25/B/NZ3/00431 Narodowe Centrum Nauki
فهرسة مساهمة: Keywords: IL-33; ST2; psoriasis; skin; vitamin D
المشرفين على المادة: 0 (IL1RL1 protein, human)
0 (IL33 protein, human)
0 (Interleukin-1 Receptor-Like 1 Protein)
0 (Interleukin-33)
0 (Vitamins)
1406-16-2 (Vitamin D)
تواريخ الأحداث: Date Created: 20211210 Date Completed: 20220125 Latest Revision: 20220125
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8657669
DOI: 10.3390/ijms222312907
PMID: 34884710
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms222312907