دورية أكاديمية
أعرض في EDS

OSMAC Strategy Integrated with Molecular Networking for Accessing Griseofulvin Derivatives from Endophytic Fungi of Moquiniastrum polymorphum (Asteraceae).

التفاصيل البيبلوغرافية
العنوان: OSMAC Strategy Integrated with Molecular Networking for Accessing Griseofulvin Derivatives from Endophytic Fungi of Moquiniastrum polymorphum (Asteraceae).
المؤلفون: Farinella VF; Departamento de Botânica, Instituto de Biociências, Universidade de São Paulo, São Paulo 05508-090, SP, Brazil., Kawafune ES; Departamento de Botânica, Instituto de Biociências, Universidade de São Paulo, São Paulo 05508-090, SP, Brazil., Tangerina MMP; Departamento de Botânica, Instituto de Biociências, Universidade de São Paulo, São Paulo 05508-090, SP, Brazil., Domingos HV; Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-090, SP, Brazil., Costa-Lotufo LV; Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-090, SP, Brazil., Ferreira MJP; Departamento de Botânica, Instituto de Biociências, Universidade de São Paulo, São Paulo 05508-090, SP, Brazil.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2021 Dec 02; Vol. 26 (23). Date of Electronic Publication: 2021 Dec 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Asteraceae/*microbiology , Endophytes/*chemistry , Fungi/*chemistry , Griseofulvin/*analogs & derivatives, Chromatography, High Pressure Liquid ; Griseofulvin/analysis ; Tandem Mass Spectrometry
مستخلص: Three endophytic fungi isolated from Moquiniastrum polymorphum (Less.) G. Sancho (Asteraceae) were cultivated using the one strain many compounds (OSMAC) strategy to evaluate the production of griseofulvin derivatives. Extracts obtained were analyzed by HPLC-MS/MS and the chromatographic and spectrometric data used to elaborate a feature-based molecular network (FBMN) through the GNPS platform. This approach allowed the observation of differences such as medium-specific and strain-specific production of griseofulvin derivatives and variations of cytotoxic activity in most extracts. To evaluate the efficiency of the OSMAC approach allied with FBMN analysis in the prospection of compounds of biotechnological interest, griseofulvin and 7-dechlorogriseofulvin were isolated, and the relative concentrations were estimated in all culture media using HPLC-UV, allowing for the inference of the best strain-medium combinations to maximize its production. Malt extract-peptone broth and Wickerham broth media produced the highest concentrations of both secondary metabolites.
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معلومات مُعتمدة: 2020/16554-9 and 2015/17177-6 São Paulo Research Foundation; 001 Coordenação de Aperfeicoamento de Pessoal de Nível Superior; 308952/2020-0 and 130379/2018-2 National Council for Scientific and Technological Development
فهرسة مساهمة: Keywords: Gochnatia polymorpha; compositae; dereplication; endophytes; griseofulvin derivatives; metabolomics; polyketides
المشرفين على المادة: 32HRV3E3D5 (Griseofulvin)
تواريخ الأحداث: Date Created: 20211210 Date Completed: 20220208 Latest Revision: 20240404
رمز التحديث: 20240404
مُعرف محوري في PubMed: PMC8658887
DOI: 10.3390/molecules26237316
PMID: 34885898
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules26237316