دورية أكاديمية

DNA methylation in the inflammatory genes after neurosurgery and diagnostic ability of post-operative delirium.

التفاصيل البيبلوغرافية
العنوان: DNA methylation in the inflammatory genes after neurosurgery and diagnostic ability of post-operative delirium.
المؤلفون: Yamanashi T; Stanford University School of Medicine, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA, USA. yamatake@stanford.edu.; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, USA. yamatake@stanford.edu.; Tottori University Faculty of Medicine, Department of Neuropsychiatry, Yonago-shi, Tottori, Japan. yamatake@stanford.edu., Nagao T; University of Iowa Carver College of Medicine, Department of Neurosurgery, Iowa City, IA, USA.; Toho University School of Medicine Faculty of Medicine, Department of Neurosurgery (Sakura), Sakura-shi, Chiba, Japan., Wahba NE; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, USA., Marra PS; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, USA., Crutchley KJ; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, USA., Meyer AA; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, USA., Andreasen AJ; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, USA., Hellman MM; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, USA., Jellison SS; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, USA., Hughes CG; Vanderbilt University Medical Center, Department of anesthesiology, Nashville, TN, USA., Pandharipande PP; Vanderbilt University Medical Center, Department of anesthesiology, Nashville, TN, USA., Howard Iii MA; University of Iowa Carver College of Medicine, Department of Neurosurgery, Iowa City, IA, USA., Kawasaki H; University of Iowa Carver College of Medicine, Department of Neurosurgery, Iowa City, IA, USA., Iwata M; Tottori University Faculty of Medicine, Department of Neuropsychiatry, Yonago-shi, Tottori, Japan., Hefti MM; University of Iowa Carver College of Medicine, Department of Pathology, Iowa City, IA, USA., Shinozaki G; Stanford University School of Medicine, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA, USA. gens@stanford.edu.; University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, USA. gens@stanford.edu.
المصدر: Translational psychiatry [Transl Psychiatry] 2021 Dec 09; Vol. 11 (1), pp. 627. Date of Electronic Publication: 2021 Dec 09.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Nature Pub. Group
مواضيع طبية MeSH: Delirium*/diagnosis , Delirium*/genetics , Neurosurgery*, CpG Islands ; DNA Methylation ; Epigenesis, Genetic ; Humans
مستخلص: The pathophysiological mechanisms of postoperative delirium (POD) are still not clear, and no reliable biomarker is available to differentiate those with and without POD. Pre- and post-surgery blood from epilepsy subjects undergoing neurosurgery were collected. DNA methylation (DNAm) levels of the TNF gene, IL1B gene, and IL6 gene by the Illumina EPIC array method, and DNAm levels of the TNF gene by pyrosequencing, were analyzed. Blood from 37 subjects were analyzed by the EPIC array method, and blood from 27 subjects were analyzed by pyrosequencing. Several CpGs in the TNF gene in preoperative blood showed a negative correlation between their DNAm and age both in the POD group and in the non-POD group. However, these negative correlations were observed only in the POD group after neurosurgery. Neurosurgery significantly altered DNAm levels at 17 out of 24 CpG sites on the TNF gene, 8 out of 14 CpG sites on the IL1B gene, and 4 out of 14 CpG sites on the IL6 gene. Furthermore, it was found that the Inflammatory Methylation Index (IMI), which was based on the post-surgery DNAm levels at the selected five CpG sites, can be a potential detection tool for delirium with moderate accuracy; area under the curve (AUC) value was 0.84. The moderate accuracy of this IMI was replicated using another cohort from our previous study, in which the AUC was 0.79. Our findings provide further evidence of the potential role of epigenetics and inflammation in the pathophysiology of delirium.
(© 2021. The Author(s).)
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معلومات مُعتمدة: R01 MH119165 United States MH NIMH NIH HHS
تواريخ الأحداث: Date Created: 20211210 Date Completed: 20220131 Latest Revision: 20220131
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8660911
DOI: 10.1038/s41398-021-01752-6
PMID: 34887385
قاعدة البيانات: MEDLINE
الوصف
تدمد:2158-3188
DOI:10.1038/s41398-021-01752-6