دورية أكاديمية
Amazonian scorpions and scorpionism: integrating toxinological, clinical, and phylogenetic data to combat a human health crisis in the world's most diverse rainfores.
العنوان: | Amazonian scorpions and scorpionism: integrating toxinological, clinical, and phylogenetic data to combat a human health crisis in the world's most diverse rainfores. |
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المؤلفون: | Borges A; Center for the Development of Scientific Research (CEDIC), Asunción, Paraguay.; Laboratory of Molecular Biology of Toxins and Receptors, Institute of Experimental Medicine, School of Medicine, Central University of Venezuela, Caracas, Venezuela., Graham MR; Department of Biology, Eastern Connecticut State University, Willimantic, CT, United States., Cândido DM; Laboratory of Arthropods, Butantan Institute, São Paulo, SP, Brazil., Pardal PPO; Laboratory of Medical Entomology and Venomous Animals, Center of Tropical Medicine, Federal University of Pará (UFPA), Belém, PA, Brazil. |
المصدر: | The journal of venomous animals and toxins including tropical diseases [J Venom Anim Toxins Incl Trop Dis] 2021 Nov 29; Vol. 27, pp. e20210028. Date of Electronic Publication: 2021 Nov 29 (Print Publication: 2021). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: CEVAP Country of Publication: Brazil NLM ID: 101201501 Publication Model: eCollection Cited Medium: Print ISSN: 1678-9199 (Print) Linking ISSN: 16789180 NLM ISO Abbreviation: J Venom Anim Toxins Incl Trop Dis Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Publication: 2019- : Botucatu, SP, Brazil : CEVAP Original Publication: Botucatu, SP, Brazil : CEVAP, c2003- |
مستخلص: | Venom from Amazonian scorpions of the genus Tityus contains components capable of eliciting a distinct clinical, mostly neurological, syndrome. This contrasts with the mainly autonomic manifestations produced after envenomation by congeneric southern and northern South American species. Herein, we summarize Pan-Amazonian scorpionism by synthesizing available toxinological, clinical, and molecular data gathered from all affected areas in Amazonia, including Brazil, Ecuador, Colombia, Peru, Venezuela, and French Guiana. We searched multiple databases, as well as our own records, for reports of scorpion envenomations in Amazonia by confirmed Tityus spp., and compared the clinical manifestations. To help uncover clinical and venom relationships among problematic species, we explored phylogenetic relationships with a rate-calibrated analysis of mitochondrial COI data from available species. The possible existence of diversity gradients for venom toxic and immunogenic components despite the predicted strong phylogenetic association among species is underscored by discussed clinical and toxinological findings. A multicentric effort, involving all nations affected by this neglected disease, is urgently needed to offer alternatives for treating and understanding this pathology, including the preparation of neutralizing antibodies with a broad range of efficacy. Competing Interests: Competing interests: The authors declare that they have no competing interests. |
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فهرسة مساهمة: | Keywords: Amazonia; Scorpion antivenom; Scorpionism; Tityus |
تواريخ الأحداث: | Date Created: 20211210 Latest Revision: 20240210 |
رمز التحديث: | 20240210 |
مُعرف محوري في PubMed: | PMC8629433 |
DOI: | 10.1590/1678-9199-JVATITD-2021-0028 |
PMID: | 34887908 |
قاعدة البيانات: | MEDLINE |
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