دورية أكاديمية
Fungal keratitis due to Scopulariopsis brevicaulis and a potential promising therapeutic effect of antibacterial agents: A case report.
العنوان: | Fungal keratitis due to Scopulariopsis brevicaulis and a potential promising therapeutic effect of antibacterial agents: A case report. |
---|---|
المؤلفون: | Kaplan NM; Department of Pathology and Microbiology, King Abdullah University Hospital, Jordan University of Science and Technology, Irbid, Jordan., Al-Dwairi RA; Department of Special Surgery (Ophthalmology), King Abdullah University Hospital, Jordan University of Science and Technology, Irbid, Jordan., AlRabadi NN; Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan. |
المصدر: | Medicine [Medicine (Baltimore)] 2021 Dec 10; Vol. 100 (49), pp. e28203. |
نوع المنشور: | Case Reports; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins |
مواضيع طبية MeSH: | Contact Lenses, Hydrophilic*, Anti-Bacterial Agents/*therapeutic use , Corneal Ulcer/*microbiology , Eye Infections, Fungal/*complications , Eye Infections, Fungal/*diagnosis , Keratitis/*drug therapy , Scopulariopsis/*isolation & purification, Adolescent ; Antifungal Agents/therapeutic use ; Corneal Ulcer/diagnosis ; Corneal Ulcer/drug therapy ; Eye Infections, Fungal/drug therapy ; Female ; Humans ; Keratitis/diagnosis |
مستخلص: | Introduction: Microbial keratitis is a serious potentially blinding corneal infection. Contact lens wear remains the most common predisposing factor. Fungal keratitis represent only a small fraction of the overall number of cases of contact lens-associated microbial keratitis, however they are proportionally more severe. Patient Concerns: An 18-year-old female, who occasionally used eye cosmetic soft contact lenses, presented with pain, redness, and blurring of vision in her left eye. Diagnosis: The left eye showed decreased visual acuity, central corneal ulcer and abscess, and severe ciliary injection. A provisional diagnosis of infectious keratitis was considered. Intervention: Corneal scrapings were aseptically collected and directly inoculated onto sterile bacterial and fungal agar plates that were immediately incubated. The patient was admitted and started on topical and systemic antibacterial agents. Outcomes: The infection showed signs of satisfactory clinical resolution. However, the mold Scopulariopsis brevicaulis was isolated in pure colonies 5 days after presentation. Conclusion: We report the first case from Jordan of fungal keratitis caused by the mold S brevicaulis. A high index of suspicion is required for fungal keratitis caused by S brevicaulis in immunocompetent patients who wear contact lenses despite its rarity. This fungal infection was successfully treated using antibacterial agents. However, larger studies are recommended to investigate the clinical effectiveness of antimicrobial agents that have both antibacterial and antifungal effects and to assess their role as empirical therapeutic modalities for infectious keratitis. Competing Interests: The authors have no funding and conflicts of interest to disclose. (Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.) |
References: | Stapleton F, Carnt N. Contact lens-related microbial keratitis: how have epidemiology and genetics helped us with pathogenesis and prophylaxis? Eye 2012;26:185–93. Lievens CW, Cilimberg KC, Moore A. Contact lens care tips for patients: an optometrist's perspective. Clin Optom 2017;9:113–21. Keay L, Stapleton F. Development and evaluation of evidence-based guidelines on contact lens-related microbial keratitis. Contact Lens Anterior Eye 2008;31:03–12. Carnt N, Samarawickrama C, White A, et al. The diagnosis and management of contact lens-related microbial keratitis. Clin Exp Optom 2017;100:482–93. Cuenca-Estrella M, Gomez-Lopez A, Buitrago MJ, et al. In vitro activities of 10 combinations of antifungal agents against the multiresistant pathogen Scopulariopsis brevicaulis . Antimicrob Agents Chemother 2006;50:2248–50. Bunya VY, Hammersmith KM, Rapuano CJ, et al. Topical and oral voriconazole in the treatment of fungal keratitis. Am J Ophthalmol 2007;143:151–3. Issakainen J, Salonen JH, Anttilas V-J, et al. Deep, respiratory tract and ear infections caused by Pseudallescheria ( Scedosporium ) and Microascus ( Scopulariopsis ) in Finland. A 10-year retrospective multi-center study. Med Mycol 2010;48:458–65. Steinbach WJ, Schell WA, Miller JL, et al. Fatal Scopulariopsis brevicaulis infection in a paediatric stem-cell transplant patient treated with voriconazole and caspofungin and a review of Scopulariopsis infections in immunocompromised patients. J Infect 2004;48:112–6. Sandoval-Denis M, Sutton DA, Fothergill AW, et al. Scopulariopsis , a poorly known opportunistic fungus: spectrum of species in clinical samples and in vitro response to antifungal drugs. J Clin Microbiol 2013;51:3937–43. Iwen PC, Schutte SD, Florescu DF, et al. Invasive Scopulariopsis brevicaulis infection in an immunocompromised patient and review of prior cases caused by Scopulariopsis and Microascus species. Med Mycol 2012;50:561–9. Ragge NK, Hart JCD, Easty DL, et al. A case of fungal keratitis caused by Scopulariopsis brevicaulis : treatment with antifungal agents and penetrating keratoplasty. Br J Ophthalmol 1990;74:561–2. Del Prete A, Sepe G, Ferrante M, et al. Fungal keratitis due to Scopulariopsis brevicaulis in an eye previously suffering from herpetic keratitis. Ophthalmologica 1994;208:333–5. Ansari Z, Miller D, Galor A. Current thoughts in fungal keratitis: diagnosis and treatment. Curr Fungal Infect Rep 2013;7:209–18. Matoba AY. Fungal keratitis responsive to moxifloxacin monotherapy. Cornea 2012;31:1206–9. Chodosh J, Miller D, Tu EY, Culbertson WW. Tobramycin-responsive Fusarium oxysporum keratitis. Can J Ophthalmol 2000;35:29–30. Khor WB, Aung T, Saw SM, et al. An outbreak of Fusarium keratitis associated with contact lens wear in Singapore. JAMA 2006;295:2867–73. Munir WM, Rosenfeld SI, Udell I, et al. Clinical response of contact lens-associated fungal keratitis to topical fluoroquinolone therapy. Cornea 2007;26:621–4. Rao SK, Lam PT, Li EY, et al. A case series of contact lens-associated Fusarium keratitis in Hong Kong. Cornea 2007;26:1205–9. Forster RK, Rebell G, Wilson LA. Dematiaceous fungal keratitis. Clinical isolates and management. Br J Ophthalmol 1975;59:372–6. Choy BN, Tang EW, Lai JS. A case series of contact lens associated Fusarium keratitis in Hong Kong. Cornea 2009;28:955. Lee DC, Lee JW, Chang SD. A case of Fusarium keratitis treated with moxifloxacin 0.5% ophthalmic solution. J Korean Ophthalmol Soc 2012;53:338–41. Malecha MA. Fungal keratitis caused by Scopulariopsis brevicaulis treated successfully with natamycin. Cornea 2004;23:201–3. Donnelly JP, Chen SC, Kauffman CA, et al. Revision and update of the consensus definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clin Infect Dis 2020;71:1367–76. Makimura K, Tamura Y, Mochizuki T, et al. Phylogenetic classification and species identification of dermatophyte strains based on DNA sequences of nuclear ribosomal internal transcribed spacer 1 regions. J Clin Microbiol 1999;37:920–4. Dahlgren MA, Lingappan A, Wilhelmus KR. The clinical diagnosis of microbial keratitis. Am J Ophthalmol 2007;143:940–4. Nixon HK. Preparation of fortified antimicrobial eye drops. Kerala J Ophthalmol 2018;30:152–4. Zrenner E, Tomaszewski K, Hamlin J, et al. Effects of multiple doses of voriconazole on the vision of healthy volunteers: a double-blind, placebo-controlled study. Ophthalmic Res 2014;52:43–52. Prajna NV, Krishnan T, Mascarenhas J, et al. The mycotic ulcer treatment trial: a randomized trial comparing natamycin vs voriconazole. JAMA Ophthalmol 2013;131:422–9. Gokhale NS. Medical management approach to infectious keratitis. Indian J Ophthalmol 2008;56:215–20. Bonifaz A, Cruz-Aguilar P, Ponce RM. Onychomycosis by molds. Report of 78 cases. Eur J Dermatol 2007;17:70–2. Skóra M, Bulanda M, Jagielski T. In vitro activities of a wide panel of antifungal drugs against various Scopulariopsis and Microascus species. Antimicrob Agents Chemother 2015;59:5827–9. Wang JY, Wang DQ, Qi XL, et al. Modified ulcer debridement in the treatment of the superficial fungal infection of the cornea. Int J Ophthalmol 2018;11:223–9. Day S, Lalitha P, Haug S, et al. Activity of antibiotics against Fusarium and Aspergillus . Br J Ophthalmol 2009;93:116–9. Lee HB, Kim Y, Kim JC, et al. Activity of some aminoglycoside antibiotics against true fungi, Phytophthora and Pythium species. J Appl Microbiol 2005;99:836–43. Subedi YP, AlFindee MN, Takemoto JY, et al. Antifungal amphiphilic kanamycins: new life for an old drug. Med Chem Commun 2018;9:909–19. Changa CWT, Takemoto JY. Antifungal amphiphilic aminoglycosides. Med Chem Commun 2014;8:1048–57. Alfonso E, Miller D. Impact of the 4th generation fluoroquinolones on growth rate and detection time of fungal pathogens. Invest Ophthalmol Vis Sci 2005;46:2766. Ozdek SC, Miller D, Flynn PM, et al. In vitro antifungal activity of the fourth generation fluoroquinolones against Candida isolates from human ocular infections. Ocul Immunol Inflamm 2006;14:347–51. Kawakami H, Inuzuka H, Hori N, et al. Inhibitory effects of antimicrobial agents against Fusarium species. Med Myco 2015;53:603–11. |
المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Antifungal Agents) |
تواريخ الأحداث: | Date Created: 20211210 Date Completed: 20220207 Latest Revision: 20230927 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC8663826 |
DOI: | 10.1097/MD.0000000000028203 |
PMID: | 34889303 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1536-5964 |
---|---|
DOI: | 10.1097/MD.0000000000028203 |