دورية أكاديمية
Aqueous suspensions of Fuller's earth potentiate the adsorption capacities of paraoxon and improve skin decontamination properties.
| العنوان: | Aqueous suspensions of Fuller's earth potentiate the adsorption capacities of paraoxon and improve skin decontamination properties. |
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| المؤلفون: | Danoy A; UMR 5305: Laboratoire de Biologie Tissulaire et d'Ingénierie Thérapeutique, CNRS / Université Claude Bernard Lyon 1, Institut de Biologie et Chimie des Protéines, 7 passage du Vercors, 69367 Lyon Cedex 07, France., Durmaz K; UMR 5305: Laboratoire de Biologie Tissulaire et d'Ingénierie Thérapeutique, CNRS / Université Claude Bernard Lyon 1, Institut de Biologie et Chimie des Protéines, 7 passage du Vercors, 69367 Lyon Cedex 07, France. Electronic address: kardelen.durmaz@ibcp.fr., Paoletti M; UMR 5305: Laboratoire de Biologie Tissulaire et d'Ingénierie Thérapeutique, CNRS / Université Claude Bernard Lyon 1, Institut de Biologie et Chimie des Protéines, 7 passage du Vercors, 69367 Lyon Cedex 07, France., Vachez L; UMR 5305: Laboratoire de Biologie Tissulaire et d'Ingénierie Thérapeutique, CNRS / Université Claude Bernard Lyon 1, Institut de Biologie et Chimie des Protéines, 7 passage du Vercors, 69367 Lyon Cedex 07, France., Roul A; UMR 5305: Laboratoire de Biologie Tissulaire et d'Ingénierie Thérapeutique, CNRS / Université Claude Bernard Lyon 1, Institut de Biologie et Chimie des Protéines, 7 passage du Vercors, 69367 Lyon Cedex 07, France; Pôle Santé, Direction Générale de la Sécurité Civile et de la Gestion des Crises, Ministère de l'Intérieur Paris, France., Sohier J; UMR 5305: Laboratoire de Biologie Tissulaire et d'Ingénierie Thérapeutique, CNRS / Université Claude Bernard Lyon 1, Institut de Biologie et Chimie des Protéines, 7 passage du Vercors, 69367 Lyon Cedex 07, France., Verrier B; UMR 5305: Laboratoire de Biologie Tissulaire et d'Ingénierie Thérapeutique, CNRS / Université Claude Bernard Lyon 1, Institut de Biologie et Chimie des Protéines, 7 passage du Vercors, 69367 Lyon Cedex 07, France. |
| المصدر: | Journal of hazardous materials [J Hazard Mater] 2022 Mar 05; Vol. 425, pp. 127714. Date of Electronic Publication: 2021 Nov 12. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9422688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3336 (Electronic) Linking ISSN: 03043894 NLM ISO Abbreviation: J Hazard Mater Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, |
| مواضيع طبية MeSH: | Decontamination* , Paraoxon*/toxicity, Adsorption ; Aluminum Compounds ; Animals ; Magnesium Compounds ; Silicates ; Skin ; Suspensions ; Swine ; Water |
| مستخلص: | Fuller's earth (FE) is a phyllosilicate used as a powder for household or skin decontamination due to its adsorbent properties. Recent studies have shown that water suspensions exhibit similar adsorbent capacities. FE is heterogeneous due to its composition of elementary clay aggregates and heavy metal particles. Here, FE toxicity was assessed in vitro on skin cells and in vivo on Danio rerio embryos. Among the suspensions tested (5%, 9.1% and 15% w/w), only the highest one shows weak toxicity. Suspensions were tested for ex vivo dermal decontamination into pig ear skin and human abdominal skin using diffusion cells and paraoxon as organophosphorus contaminant. After 24 h of diffusion, no difference was observed in the paraoxon concentration in the receptor compartment whether the decontamination was carried out with FE in powder or in suspension form. In presence of FE suspensions, we observed the disappearance of paraoxon from the stratum corneum, the reservoir compartment, independently of the suspensions' concentration. We suggest that water potentiates the absorbing capacities of FE powder by intercalating between clay lamellas leading to the appearance of new adsorption zones and swelling. These data support the use of FE aqueous suspensions as a safe tool for organophosphorus skin decontamination. (Copyright © 2021 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Decontamination efficiency; Paraoxon; Skin penetration; Smectite; Toxicity |
| المشرفين على المادة: | 0 (Aluminum Compounds) 0 (Magnesium Compounds) 0 (Silicates) 0 (Suspensions) 059QF0KO0R (Water) 8031-18-3 (Fuller's Earth) Q9CX8P80JW (Paraoxon) |
| تواريخ الأحداث: | Date Created: 20211213 Date Completed: 20220127 Latest Revision: 20220127 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jhazmat.2021.127714 |
| PMID: | 34896712 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3336 |
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| DOI: | 10.1016/j.jhazmat.2021.127714 |