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Pre-transplant maintenance dialysis duration and outcomes after kidney transplantation: A multicenter population-based cohort study.

التفاصيل البيبلوغرافية
العنوان: Pre-transplant maintenance dialysis duration and outcomes after kidney transplantation: A multicenter population-based cohort study.
المؤلفون: Naylor KL; ICES, Ontario, Canada.; Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada., Kim SJ; ICES, Ontario, Canada.; Division of Nephrology, University Health Network, University of Toronto, Toronto, Ontario, Canada., Kuwornu JP; ICES, Ontario, Canada., Dixon SN; ICES, Ontario, Canada.; Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada., Garg AX; ICES, Ontario, Canada.; Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.; Division of Nephrology, Western University, London, Ontario, Canada., McCallum MK; ICES, Ontario, Canada., Knoll GA; Department of Medicine (Nephrology), University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
المصدر: Clinical transplantation [Clin Transplant] 2022 Mar; Vol. 36 (3), pp. e14553. Date of Electronic Publication: 2022 Jan 07.
نوع المنشور: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 8710240 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-0012 (Electronic) Linking ISSN: 09020063 NLM ISO Abbreviation: Clin Transplant Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Copenhagen : Munksgaard,
مواضيع طبية MeSH: Cardiovascular Diseases*/etiology , Kidney Failure, Chronic*/etiology , Kidney Transplantation*, Cohort Studies ; Female ; Graft Rejection/epidemiology ; Graft Rejection/etiology ; Graft Survival ; Humans ; Male ; Ontario/epidemiology ; Renal Dialysis ; Time Factors ; Treatment Outcome
مستخلص: The association between pre-transplant dialysis duration and post-transplant outcomes may vary by the population and endpoints studied. We conducted a population-based cohort study using linked healthcare databases from Ontario, Canada including kidney transplant recipients (n = 4461) from 2004 to 2014. Our primary outcome was total graft failure (i.e., death, return to dialysis, or pre-emptive re-transplant). Secondary outcomes included death-censored graft failure, death with graft function, mortality, hospitalization for cardiovascular events, hospitalization for infection, and hospital readmission. We presented results by pre-transplant dialysis duration (pre-emptive transplant, and .01-1.43, 1.44-2.64, 2.65-4.25, 4.26-6.45, and 6.46-36.5 years, for quintiles 1-5). After adjusting for clinical characteristics, pre-emptive transplantation was associated with a lower rate of total graft failure (adjusted hazard ratio [aHR] .68, 95% CI: .46, .99), while quintile 4 was associated with a higher rate (aHR 1.31, 95% CI: 1.01, 1.71), when compared to quintile 1. There was no significant relationship between dialysis duration and death-censored graft failure, cardiovascular events, or hospital readmission. For death with graft function and mortality, quintiles 3-5 had a significantly higher aHR compared to quintile 1, while for infection, quintiles 2-5 had a higher aHR. Longer time on dialysis was associated with an increased rate of several adverse post-transplant outcomes.
(© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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معلومات مُعتمدة: Canada CIHR
فهرسة مساهمة: Keywords: dialysis duration; graft failure; infection; kidney transplant; mortality
تواريخ الأحداث: Date Created: 20211213 Date Completed: 20220425 Latest Revision: 20220425
رمز التحديث: 20221213
DOI: 10.1111/ctr.14553
PMID: 34897824
قاعدة البيانات: MEDLINE
الوصف
تدمد:1399-0012
DOI:10.1111/ctr.14553