دورية أكاديمية
أعرض في EDS

In vivo antiplasmodial activity of hydromethanolic leaf extract and solvent fractions of Maytenus gracilipes (Celastraceae) against Plasmodium berghei in mice.

التفاصيل البيبلوغرافية
العنوان: In vivo antiplasmodial activity of hydromethanolic leaf extract and solvent fractions of Maytenus gracilipes (Celastraceae) against Plasmodium berghei in mice.
المؤلفون: Nureye D; Department of Pharmacology and Toxicology, School of Pharmacy, College of Medicine and Health Sciences, P. O. Box 260, Mizan-Aman, Ethiopia., Kedir MS; Department of Pharmacy, College of Health Sciences, Arsi University, P. O. Box 193, Asella, Ethiopia., Muluye RA; Ethiopian Public Health Institute, Addis Ababa, Ethiopia., Hammeso WW; Department of Pharmacology and Toxicology, School of Pharmacy, College of Medicine and Health Sciences, P. O. Box 260, Mizan-Aman, Ethiopia., Tekalign E; Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Mizan-Tepi University, Mizan-Aman, Ethiopia.
المصدر: Heliyon [Heliyon] 2021 Nov 24; Vol. 7 (11), pp. e08457. Date of Electronic Publication: 2021 Nov 24 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : Elsevier Ltd, [2015]-
مستخلص: Background: The incidence of resistance among currently available antimalarial drugs, as well as the high economic cost of malaria, has prompted researchers to look for novel antimalarial molecules. As a result, the current study was proposed to evaluate the antiplasmodial activity ( in vivo ) of Maytenus gracilipes based on the plant's traditional claims.
Methods: A cold maceration procedure using 80% methanol as a solvent was employed to obtain a crude extract from M. gracilipes leaves. Chloroform, n-butanol, and pure water were used to fractionate the hydromethanolic extract. Standard procedures were followed for an acute oral toxicity test. The antimalarial effects of the plant at 200, 400, and 600 mg/kg doses were investigated using three rodent malaria models (4-day suppressive, rane's, and repository tests). Thirty mice were utilized in each experiment (3 treatment and 2 control groups, each with six mice). Parasitemia, survival time, body weight, temperature, and packed cell volume were all used to assess the extracts' antiplasmodial activity. To compare results between groups, a one-way ANOVA with Post Hoc Tukey's HSD was used.
Results: In a 4-day suppressive investigation, all doses of the crude extract and fractions suppressed parasitemia significantly (P < 0.001) as compared to the negative control. The crude extract had the greatest chemosuppressive effect (74.15%) at 600 mg/kg dose. Chloroform had the greatest parasitemia suppression among the fractions; however it was less than the crude extract. In Rane's test, all doses of the crude extract produced substantial (P < 0.001) curative effects as compared to the negative control.
Conclusion: According to this study, the crude extract and solvent fractions of M. gracilipes leaves contain antimalarial activity with a substantial suppressive effect. The antiplasmodial effects were more active in the chloroform and n-butanol fractions, indicating that the plant's non-polar and medium polar constituents are responsible. Nonetheless, further analysis is required to isolate and characterize the active compounds responsible for the study plant's antimalarial activity.
Competing Interests: The authors declare no conflict of interest.
(© 2021 The Author(s).)
References: Evid Based Complement Alternat Med. 2021 Sep 01;2021:9625169. (PMID: 34512786)
Iran J Parasitol. 2012;7(4):62-74. (PMID: 23323093)
Molecules. 2010 Dec 28;16(1):107-18. (PMID: 21189459)
J Ethnopharmacol. 2000 Feb;69(2):127-37. (PMID: 10687869)
BMC Complement Altern Med. 2014 Mar 01;14:79. (PMID: 24580778)
J Exp Pharmacol. 2021 Jul 14;13:661-668. (PMID: 34285599)
J Ethnopharmacol. 2013 Mar 27;146(2):557-61. (PMID: 23376043)
Infect Drug Resist. 2021 Jul 06;14:2583-2596. (PMID: 34262303)
Exp Parasitol. 1965 Aug;17(1):80-9. (PMID: 5843289)
J Ethnopharmacol. 2007 Jul 25;112(3):545-51. (PMID: 17572031)
Bio Protoc. 2015 Jul 5;5(13):. (PMID: 26236758)
J Exp Pharmacol. 2020 Sep 07;12:313-323. (PMID: 32982487)
An Acad Bras Cienc. 2009 Dec;81(4):715-40. (PMID: 19893898)
Malar J. 2011 Mar 15;10 Suppl 1:S4. (PMID: 21411015)
SAGE Open Med. 2019 May 13;7:2050312119849766. (PMID: 31205692)
Chin Med. 2018 Apr 17;13:20. (PMID: 29692864)
Chem Immunol. 2002;80:204-28. (PMID: 12058640)
BMC Complement Altern Med. 2015 Dec 23;15:448. (PMID: 26698300)
Afr J Tradit Complement Altern Med. 2009 Mar 07;6(2):163-7. (PMID: 20209008)
Evid Based Complement Alternat Med. 2020 Sep 17;2020:5384804. (PMID: 33014107)
Evid Based Complement Alternat Med. 2020 Jun 09;2020:9467359. (PMID: 32595751)
Malar J. 2017 Aug 1;16(1):307. (PMID: 28764723)
Cold Spring Harb Perspect Med. 2017 Jul 5;7(7):. (PMID: 28289248)
Nat Rev Drug Discov. 2004 Jun;3(6):509-20. (PMID: 15173840)
J Evid Based Integr Med. 2020 Jan-Dec;25:2515690X20920539. (PMID: 32321294)
Mem Inst Oswaldo Cruz. 2012 Nov;107(7):831-45. (PMID: 23147137)
J Ethnopharmacol. 2012 Jan 6;139(1):221-7. (PMID: 22101085)
Malar J. 2015 Feb 14;14:79. (PMID: 25890324)
J Infect Dis. 2019 Jan 7;219(2):315-322. (PMID: 30102351)
J Trop Med. 2021 Mar 04;2021:8863002. (PMID: 33747096)
Ann Trop Med Parasitol. 1975 Jun;69(2):155-71. (PMID: 1098584)
Evid Based Complement Alternat Med. 2018 Jun 12;2018:9217835. (PMID: 30008788)
JAMA. 2021 Jun 15;325(23):2335. (PMID: 34128992)
Ann Trop Med Parasitol. 1970 Jun;64(2):209-22. (PMID: 4992592)
PLoS One. 2012;7(9):e45906. (PMID: 23029306)
J Evid Based Integr Med. 2021 Jan-Dec;26:2515690X20984287. (PMID: 33593094)
Afr J Tradit Complement Altern Med. 2011;8(1):1-10. (PMID: 22238476)
J Ethnopharmacol. 2005 May 13;99(1):137-43. (PMID: 15848033)
Evid Based Complement Alternat Med. 2021 Jun 16;2021:6664711. (PMID: 34221087)
فهرسة مساهمة: Keywords: Antiplasmodial activity; Extract; Fraction; In vivo; Maytenus gracilipes
تواريخ الأحداث: Date Created: 20211213 Latest Revision: 20230921
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8642609
DOI: 10.1016/j.heliyon.2021.e08457
PMID: 34901504
قاعدة البيانات: MEDLINE
الوصف
تدمد:2405-8440
DOI:10.1016/j.heliyon.2021.e08457