دورية أكاديمية
أعرض في EDS

Copy number variants in genomes of local sheep breeds from Russia.

التفاصيل البيبلوغرافية
العنوان: Copy number variants in genomes of local sheep breeds from Russia.
المؤلفون: Igoshin AV; The Federal Research Center Institute of Cytology and Genetics SB RAS, Novosibirsk, 630090, Russia., Deniskova TE; L.K. Ernst Federal Research Center for Animal Husbandry, Podolsk, 142132, Russia., Yurchenko AA; The Federal Research Center Institute of Cytology and Genetics SB RAS, Novosibirsk, 630090, Russia., Yudin NS; The Federal Research Center Institute of Cytology and Genetics SB RAS, Novosibirsk, 630090, Russia.; Novosibirsk State University, Novosibirsk, 630090, Russia., Dotsev AV; L.K. Ernst Federal Research Center for Animal Husbandry, Podolsk, 142132, Russia., Selionova MI; Russian State Agrarian University, Moscow Timiryazev Agricultural Academy, Moscow, 127550, Russia., Zinovieva NA; L.K. Ernst Federal Research Center for Animal Husbandry, Podolsk, 142132, Russia., Larkin DM; The Federal Research Center Institute of Cytology and Genetics SB RAS, Novosibirsk, 630090, Russia.; Royal Veterinary College, University of London, London, NW1 0TU, UK.
المصدر: Animal genetics [Anim Genet] 2022 Feb; Vol. 53 (1), pp. 119-132. Date of Electronic Publication: 2021 Dec 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 8605704 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2052 (Electronic) Linking ISSN: 02689146 NLM ISO Abbreviation: Anim Genet Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford, England : Wiley-Blackwell
Original Publication: Oxford, England : Published by Blackwell Scientific Publications for the International Society for Animal Blood Group Research, c1986-
مواضيع طبية MeSH: DNA Copy Number Variations* , Genome*, Sheep, Domestic/*genetics, Animals ; Russia ; Wool
مستخلص: Copy number variants (CNVs) are genomic structural variations that contribute to many adaptive and economically important traits in livestock. In this study, we detected CNVs in 354 animals from 16 Russian indigenous sheep breeds and analysed their possible functional roles. Our analysis of the entire sample set resulted in 4527 CNVs forming 1450 CNV regions (CNVRs). When constructing CNVRs for individual breeds, a total of 2715 regions ranging from 88 in Groznensk to 337 in Osetin breeds were identified. To make interbreed CNVR frequency comparison possible, we also identified core CNVRs using CNVs with overlapping chromosomal locations found in different breeds. This resulted in 137 interbreed CNVRs with frequency >15% in at least one breed. Functional enrichment analysis of genes affected by CNVRs in individual breeds revealed 12 breeds with significant enrichments in olfactory perception, PRAME family proteins, and immune response. Function of genes affected by interbreed and breed-specific CNVRs revealed candidates related to domestication, adaptation to high altitudes and cold climates, reproduction, parasite resistance, milk and meat qualities, wool traits, fat storage, and fat metabolism. Our work is the first attempt to uncover and characterise the CNV makeup of Russian indigenous sheep breeds. Further experimental and functional validation of CNVRs would help in developing new and improving existing sheep breeds.
(© 2021 Stichting International Foundation for Animal Genetics.)
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معلومات مُعتمدة: 19-76-20026 Russian Science Foundation; 21-66-00007 Russian Science Foundation
فهرسة مساهمة: Keywords: PennCNV; Russian Federation; adaptation; copy number variant regions; copy number variants; economically important trait; local sheep breeds
تواريخ الأحداث: Date Created: 20211214 Date Completed: 20220120 Latest Revision: 20220120
رمز التحديث: 20231215
DOI: 10.1111/age.13163
PMID: 34904242
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2052
DOI:10.1111/age.13163