دورية أكاديمية
Serum 8-Hydroxydeoxyguanosine Is a Potential Indicator for the Severity and Prognosis in Patients with Community-Acquired Pneumonia: A Prospective Cohort Study.
| العنوان: | Serum 8-Hydroxydeoxyguanosine Is a Potential Indicator for the Severity and Prognosis in Patients with Community-Acquired Pneumonia: A Prospective Cohort Study. |
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| المؤلفون: | Cao LF; Department of Respiratory Medicine, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China., Cheng JY; Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; and., Xu Z; Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; and., Feng CM; Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; and., Zhao H; Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; and fulindev@126.com zhaohuichenxi@126.com wangxinming@ahmu.edu.cn., Wang XM; Department of Pharmacy, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China fulindev@126.com zhaohuichenxi@126.com wangxinming@ahmu.edu.cn., Fu L; Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; and fulindev@126.com zhaohuichenxi@126.com wangxinming@ahmu.edu.cn. |
| المصدر: | Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2022 Jan 15; Vol. 208 (2), pp. 321-327. Date of Electronic Publication: 2021 Dec 15. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Bethesda, MD : American Association of Immunologists Original Publication: Baltimore : Williams & Wilkins, c1950- |
| مواضيع طبية MeSH: | Severity of Illness Index*, 8-Hydroxy-2'-Deoxyguanosine/*blood , Community-Acquired Infections/*pathology , Pneumonia/*blood , Pneumonia/*mortality, Aged ; Biomarkers/blood ; Community-Acquired Infections/blood ; Critical Care/statistics & numerical data ; Cytokines/blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Oxidative Stress/physiology ; Pneumonia/pathology ; Prognosis ; Prospective Studies ; Respiration, Artificial/statistics & numerical data |
| مستخلص: | Previous studies have demonstrated that 8-hydroxydeoxyguanosine (8-OHdG) exerted key roles in various pulmonary diseases, but the evidence for its role in community-acquired pneumonia (CAP) was lacking. The goal of this research was to evaluate the correlations of serum 8-OHdG with the severity and prognosis among patients with CAP through a prospective cohort study. A total of 239 patients with CAP and 239 healthy participants were enrolled. Fasting blood samples were collected. 8-OHdG and inflammatory cytokines were measured by ELISA. On admission, serum 8-OHdG was significantly increased in patients with CAP compared with control subjects. Besides, serum 8-OHdG was incrementally increased in line with CAP severity scores. Pearson correlative analysis found that serum 8-OHdG was correlated with clinical characteristics and inflammatory cytokines in patients with CAP. Linear and logistic regression analysis showed that serum 8-OHdG was positively associated with CAP severity scores. Furthermore, the prognostic outcomes were tracked. Higher serum 8-OHdG on admission increased the risks for intensive care unit admission, mechanical ventilation, vasoactive agent usage, death, and longer hospital stay among patients with CAP. Serum 8-OHdG combination with confusion, respiratory rate, blood pressure, and age ≥65 y or pneumonia severity index had stronger predictive powers for death than single 8-OHdG, CAP severity scores, or several inflammatory cytokines in patients with CAP. These results indicated that serum 8-OHdG is positively associated with the severity and poor prognosis in patients with CAP, demonstrating that 8-OHdG may be involved in the pathophysiology process of CAP. (Copyright © 2022 by The American Association of Immunologists, Inc.) |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Cytokines) 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine) |
| تواريخ الأحداث: | Date Created: 20211216 Date Completed: 20220201 Latest Revision: 20220201 |
| رمز التحديث: | 20240829 |
| DOI: | 10.4049/jimmunol.2100711 |
| PMID: | 34911771 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1550-6606 |
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| DOI: | 10.4049/jimmunol.2100711 |