دورية أكاديمية
The Influence of Matrix-Induced Dormancy on Metastatic Breast Cancer Chemoresistance.
العنوان: | The Influence of Matrix-Induced Dormancy on Metastatic Breast Cancer Chemoresistance. |
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المؤلفون: | Farino CJ; Department of Biomedical Engineering, University of Delaware, Newark, Delaware 19716, United States., Pradhan S; Department of Biomedical Engineering, University of Delaware, Newark, Delaware 19716, United States., Slater JH; Department of Biomedical Engineering and Department of Material Science and Engineering, University of Delaware, Newark, Delaware 19716, United States; Delaware Biotechnology Institute, Newark, Delaware 19711, United States. |
المصدر: | ACS applied bio materials [ACS Appl Bio Mater] 2020 Sep 21; Vol. 3 (9), pp. 5832-5844. Date of Electronic Publication: 2020 Aug 06. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: ACS Publications Country of Publication: United States NLM ID: 101729147 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2576-6422 (Electronic) Linking ISSN: 25766422 NLM ISO Abbreviation: ACS Appl Bio Mater Subsets: PubMed not MEDLINE; MEDLINE |
أسماء مطبوعة: | Original Publication: Washington, DC : ACS Publications, [2018]- |
مستخلص: | Metastasis remains the leading cause of cancer-associated death worldwide. Disseminated tumor cells can undergo dormancy upon infiltration of secondary organs, and chemotherapeutics fail to effectively eliminate dormant populations. Mechanistic understanding of dormancy-associated chemoresistance could lead to development of targeted therapeutic strategies. Toward this goal, we implemented three poly(ethylene glycol) (PEG)-based hydrogel formulations fabricated from proteolytically degradable PEG (PEG-PQ), integrin ligating PEG-RGDS, and the non-degradable cross-linker N -vinylpyrrolidone (NVP) to induce three distinct phenotypes in triple negative MDA-MB-231 breast cancer cells. With constant 5% w/v PEG-PQ, PEG-RGDS and NVP concentrations were tuned to induce (i) a growth state characterized by high proliferation, high metabolic activity, significant temporally increased cell density, and an invasive morphology; (ii) a balanced dormancy state characterized by a temporal balance (~1:1 ratio) in new live and dead cell density and a non-invasive morphology; and (iii) a cellular dormancy state characterized by rounded, solitary quiescent cells with low viability, proliferation, and metabolic activity. The cellular responses to doxorubicin (DOX), paclitaxel (PAC), and 5-fluorouracil (5-FU) in the three phenotypic states were quantified. Under DOX treatment, cells in dormant states demonstrated increased chemoresistance with a 1.4- to 1.8-fold increase in half maximal effective concentration (EC |
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معلومات مُعتمدة: | P20 GM103446 United States GM NIGMS NIH HHS; R21 CA214299 United States CA NCI NIH HHS |
فهرسة مساهمة: | Keywords: drug screening; extracellular matrix; latency; metastasis; tissue engineering |
تواريخ الأحداث: | Date Created: 20211216 Latest Revision: 20220210 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC8670599 |
DOI: | 10.1021/acsabm.0c00549 |
PMID: | 34913030 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2576-6422 |
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DOI: | 10.1021/acsabm.0c00549 |