دورية أكاديمية
Glucan Particles: Choosing the Appropriate Size to Use as a Vaccine Adjuvant.
| العنوان: | Glucan Particles: Choosing the Appropriate Size to Use as a Vaccine Adjuvant. |
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| المؤلفون: | Colaço M; Center for Neurosciences and Cell Biology, Coimbra, Portugal.; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal., Panão Costa J; Center for Neurosciences and Cell Biology, Coimbra, Portugal.; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal., Borges O; Center for Neurosciences and Cell Biology, Coimbra, Portugal. olga@ci.uc.pt.; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. olga@ci.uc.pt. |
| المصدر: | Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2412, pp. 269-280. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Totowa, NJ : Humana Press Original Publication: Clifton, N.J. : Humana Press, |
| مواضيع طبية MeSH: | Nanoparticles*, Adjuvants, Immunologic ; Adjuvants, Pharmaceutic ; Adjuvants, Vaccine ; Antigens ; Glucans ; beta-Glucans |
| مستخلص: | Beta-glucans are a group of polysaccharides with intrinsic immunostimulatory properties which makes the design of new particulate vaccine adjuvants based on β-glucans very promising. The size of the particles and the antigen loading method, encapsulated into particles or adsorbed on its surface, will influence the toxicological and adjuvanticity properties of the particulate adjuvant. Herein we describe the production of glucan nanoparticles (NPs) with three different sizes, approximately 150 nm, 350 nm, and microparticles as shells (GPs) with approximately 3 μm. The association of the antigen to the particulate adjuvant is described using model protein antigens. The method can be easily adapted for real protein antigens. (© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Adjuvants; Antigen loading; Glucan; Microparticles; Nanoparticles; Particle size |
| المشرفين على المادة: | 0 (Adjuvants, Immunologic) 0 (Adjuvants, Pharmaceutic) 0 (Adjuvants, Vaccine) 0 (Antigens) 0 (Glucans) 0 (beta-Glucans) |
| تواريخ الأحداث: | Date Created: 20211217 Date Completed: 20220120 Latest Revision: 20220120 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/978-1-0716-1892-9_13 |
| PMID: | 34918250 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1940-6029 |
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| DOI: | 10.1007/978-1-0716-1892-9_13 |