دورية أكاديمية
Recombinant Vaccine Design Against Clostridium spp. Toxins Using Immunoinformatics Tools.
| العنوان: | Recombinant Vaccine Design Against Clostridium spp. Toxins Using Immunoinformatics Tools. |
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| المؤلفون: | Rodrigues RR; Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil., Ferreira MRA; Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil., Kremer FS; Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil., Donassolo RA; Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil., Júnior CM; Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil., Alves MLF; Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil., Conceição FR; Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil. fabricio.rochedo@ufpel.edu.br. |
| المصدر: | Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2412, pp. 457-470. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Totowa, NJ : Humana Press Original Publication: Clifton, N.J. : Humana Press, |
| مواضيع طبية MeSH: | Computational Biology* , Vaccine Development*, Animals ; Antigens ; Clostridium ; Epitopes/genetics ; Epitopes, T-Lymphocyte ; Vaccines, Synthetic/genetics |
| مستخلص: | The emergence of recombinant DNA technology has led to the exploration of the use of the technology to develop novel vaccines. With a fundamental role in vaccines design, several immunoinformatics tools have been created to identify isolated epitopes that stimulate a specific immune response, contributing to effective vaccines development. In the past, vaccine development projects relied entirely on animal experimentation, a relatively expensive and time-consuming process. Currently, use of immunoinformatics tools play a vital role in the antigen analysis and refinement, allowing the identification of possible protective epitopes capable of stimulating convenient humoral or cellular immune responses, in addition to facilitating time and cost reduction of vaccine production. The vaccination aimed at bacterial species of Clostridium spp. has been considered a promising example of use of these approaches in recent years. Based on the literature search, it is possible to understand the best immunoinformatics software used by researchers that facilitate recombinant vaccine antigens design and development. This chapter presents an overview of how these tools are supporting the antigen engineering, aiming at increasing the efficiency of inducing protective immune response in animals. (© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Bioinformatics; Clostridiosis; Recombinant antigens; Recombinant vaccines |
| المشرفين على المادة: | 0 (Antigens) 0 (Epitopes) 0 (Epitopes, T-Lymphocyte) 0 (Vaccines, Synthetic) |
| تواريخ الأحداث: | Date Created: 20211217 Date Completed: 20220120 Latest Revision: 20220120 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1007/978-1-0716-1892-9_25 |
| PMID: | 34918262 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1940-6029 |
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| DOI: | 10.1007/978-1-0716-1892-9_25 |