تقرير
The Future of Cardiac Magnetic Resonance Clinical Trials.
| العنوان: | The Future of Cardiac Magnetic Resonance Clinical Trials. |
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| المؤلفون: | Rabbat MG; Division of Cardiology, Loyola University Chicago, Chicago, Illinois, USA; Division of Cardiology, Edward Hines Jr VA Hospital, Hines, Illinois, USA., Kwong RY; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. Electronic address: rykwong@partners.org., Heitner JF; Department of Medicine, New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, USA., Young AA; Department of Biomedical Engineering, King's College London, London, United Kingdom., Shanbhag SM; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA., Petersen SE; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, West Smithfield, London, United Kingdom; National Institute for Health Research Barts Biomedical Research Centre, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom., Selvanayagam JB; College of Medicine, Flinders University of South Australia, Department of Cardiovascular Medicine, Flinders Medical Centre, Southern Adelaide Local Health Network, and Cardiac Imaging Research Group, South Australian Health and Medical Research Institute, Adelaide, South Australia., Berry C; West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, and British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Scotland, United Kingdom., Nagel E; Institute for Experimental and Translational Cardiovascular Imaging, Klinikum der Johann Wolfgang Goethe-Universitat Frankfurt, Frankfurt am Main, Germany., Heydari B; Stephenson Cardiac Imaging Centre and Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, and Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada., Maceira AM; Cardiovascular Unit, Ascires Biomedical Group, and Department of Medicine, Health Sciences School, UCH-CEU University, Valencia, Spain., Shenoy C; Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Dyke C; Division of Cardiology, National Jewish Health, Denver, Colorado, USA., Bilchick KC; Division of Cardiovascular Medicine, University of Virginia Health System, Charlottesville, Virginia, USA. |
| مؤلفون مشاركون: | Society for Cardiovascular Magnetic Resonance |
| المصدر: | JACC. Cardiovascular imaging [JACC Cardiovasc Imaging] 2022 Dec; Vol. 15 (12), pp. 2127-2138. Date of Electronic Publication: 2021 Dec 15. |
| نوع المنشور: | Editorial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101467978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-7591 (Electronic) Linking ISSN: 18767591 NLM ISO Abbreviation: JACC Cardiovasc Imaging Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York : Elsevier |
| مواضيع طبية MeSH: | Prospective Studies*, Humans ; Predictive Value of Tests ; Magnetic Resonance Spectroscopy |
| مستخلص: | Over the past 2 decades, cardiac magnetic resonance (CMR) has become an essential component of cardiovascular clinical care and contributed to imaging-guided diagnosis and management of coronary artery disease, cardiomyopathy, congenital heart disease, cardio-oncology, valvular, and vascular disease, amongst others. The widespread availability, safety, and capability of CMR to provide corresponding anatomical, physiological, and functional data in 1 imaging session can improve the design and conduct of clinical trials through both a reduction of sample size and provision of important mechanistic data that may augment clinical trial findings. Moreover, prospective imaging-guided strategies using CMR can enhance safety, efficacy, and cost-effectiveness of cardiovascular pathways in clinical practice around the world. As the future of large-scale clinical trial design evolves to integrate personalized medicine, cost-effectiveness, and mechanistic insights of novel therapies, the integration of CMR will continue to play a critical role. In this document, the attributes, limitations, and challenges of CMR's integration into the future design and conduct of clinical trials will also be covered, and recommendations for trialists will be explored. Several prominent examples of clinical trials that test the efficacy of CMR-imaging guided pathways will also be discussed. Competing Interests: Funding Support and Author Disclosures Dr Petersen provides consultant services to and is a shareholder in Circle Cardiovascular Imaging, Inc. Dr Nagel has received speaker fees, consulting fees, and grant support from Bayer AG; and has received research grant support from NeoSoft. Dr Bilchick has received research grant support from Siemens Healthineers and Medtronic, Inc. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. (Copyright © 2022 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.) |
| معلومات مُعتمدة: | MR/N003403/1 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: cardiac magnetic resonance; clinical trials |
| تواريخ الأحداث: | Date Created: 20211219 Date Completed: 20221215 Latest Revision: 20230112 |
| رمز التحديث: | 20230112 |
| DOI: | 10.1016/j.jcmg.2021.07.029 |
| PMID: | 34922874 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1876-7591 |
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| DOI: | 10.1016/j.jcmg.2021.07.029 |