دورية أكاديمية
Investigation of Pharmacokinetic Parameters of Trelagliptin in Egyptian Volunteers Using Sensitive LC-MS/MS: A Comparative Study with a Japanese Population.
| العنوان: | Investigation of Pharmacokinetic Parameters of Trelagliptin in Egyptian Volunteers Using Sensitive LC-MS/MS: A Comparative Study with a Japanese Population. |
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| المؤلفون: | Mowaka S; Pharmaceutical Chemistry Department, Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, Cairo, Egypt.; The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, Cairo, Egypt.; Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, Ain Helwan, Cairo, Egypt., Ashoush N; Clinical Pharmacy Practice Department, School of Pharmacy, NewGiza University, Cairo, Egypt., Tadros MM; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Ain Shams University, El-Abaseya, Cairo, Egypt., Ayoub BM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, Cairo, Egypt.; The Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt, El-Sherouk City, Cairo, Egypt. |
| المصدر: | Journal of analytical methods in chemistry [J Anal Methods Chem] 2021 Dec 09; Vol. 2021, pp. 9664099. Date of Electronic Publication: 2021 Dec 09 (Print Publication: 2021). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Hindawi Pub. Corp Country of Publication: Egypt NLM ID: 101575377 Publication Model: eCollection Cited Medium: Print ISSN: 2090-8865 (Print) Linking ISSN: 20908873 NLM ISO Abbreviation: J Anal Methods Chem Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Cario : Hindawi Pub. Corp. |
| مستخلص: | Trelagliptin (TLN) is a novel once-weekly antidiabetic drug that enhanced the patient compliance in type 2 diabetes. TLN analysis and bioanalysis literature review showed many methods for TLN assay either in dosage form or as biological fluids (pharmacokinetic parameters), but all those methods did not consider the full details dealing with biological assay of TLN. Studies that included information about pharmacokinetic parameters did not mention the used analytical procedures for those determinations and parameters. Although some LC-MS/MS and UPLC-UV methods were reported for TLN bioassay in rats' plasma, they used direct precipitation techniques, and the current described procedure showed lower LLOQ than all the reported methods in spite of that working on human plasma is more complicated than on rats' plasma. In this study, LC-MS/MS bioanalysis of TLN in human plasma (4-1000 nM) was employed successfully with LLOQ of 4 nM which is lower than all reported methods in rats' plasma followed by a preliminary pharmacokinetic study. Alogliptin was used as internal standard (IS) because of its structure similarity to TLN. Pharmacokinetic parameters of TLN were investigated in Egyptian volunteers, and they had been compared to Japanese. Liquid-liquid extraction showed more sensitive results than direct precipitation. The proposed method was successfully applied to a pharmacokinetic study conducted on Egyptian volunteers. No dose modification is required upon comparing the pharmacokinetic parameters of the current study and previous studies on non-Egyptian volunteers. Competing Interests: The authors declare no conflicts of interest. (Copyright © 2021 Shereen Mowaka et al.) |
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| تواريخ الأحداث: | Date Created: 20211220 Latest Revision: 20211221 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8677398 |
| DOI: | 10.1155/2021/9664099 |
| PMID: | 34925935 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2090-8865 |
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| DOI: | 10.1155/2021/9664099 |