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Aggregation-Induced Emission Featured Supramolecular Tubisomes for Imaging-Guided Drug Delivery.

التفاصيل البيبلوغرافية
العنوان: Aggregation-Induced Emission Featured Supramolecular Tubisomes for Imaging-Guided Drug Delivery.
المؤلفون: Yang J; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.; College of Science, Nanjing Forestry University, Nanjing, 210037, P. R. China., Yu X; Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China., Song JI; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK., Song Q; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK., Hall SCL; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK., Yu G; Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China., Perrier S; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2022 Feb 21; Vol. 61 (9), pp. e202115208. Date of Electronic Publication: 2022 Jan 14.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE
أسماء مطبوعة: Publication: <2004-> : Weinheim : Wiley-VCH
Original Publication: Weinheim/Bergstr. : New York, : Verlag Chemie ; Academic Press, c1962-
مواضيع طبية MeSH: Drug Delivery Systems*, Antibiotics, Antineoplastic/*chemistry , Doxorubicin/*chemistry, Fluorescence ; Humans ; Macromolecular Substances/chemical synthesis ; Macromolecular Substances/chemistry ; Nanostructures/chemistry
مستخلص: Polymeric cylinders, a fascinating type of nanostructures with high surface area, internal volume and rigidity, have been exploited as novel drug delivery vehicles over the past decade. However, it's still an open challenge to afford cylindrical nanostructures using polymeric building blocks via traditional self-assembly processes. Herein, we report a hierarchical self-assembly strategy of preparing cylindrical aggregates (tubisomes) from an amphiphilic supramolecular bottlebrush polymer in which a cyclic peptide nanotube is employed as the noncovalent backbone. Additionally, an aggregation-induced emission (AIE) effect was introduced into the tubisomes to endow them with excellent fluorescent properties. Intriguingly, by encapsulating with the anticancer drug doxorubicin (DOX), both the fluorescence of tubisome and DOX can be quenched due to the energy transfer relay (ETR) effect. The release of DOX can induce the interruption of the ETR effect and recover the silenced fluorescence, thereby permitting the in-situ imaging of drug release. The AIE-featured supramolecular tubisomes reported here provide an alternative approach for fabricating cylindrical polymeric nanostructures and holds great potential for imaging-guided drug delivery.
(© 2021 Wiley-VCH GmbH.)
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فهرسة مساهمة: Keywords: Aggregation-Induced Emission; Cyclic Peptide; Drug Delivery; FRET; Supramolecular Tubisomes
المشرفين على المادة: 0 (Antibiotics, Antineoplastic)
0 (Macromolecular Substances)
80168379AG (Doxorubicin)
تواريخ الأحداث: Date Created: 20211220 Date Completed: 20220322 Latest Revision: 20220322
رمز التحديث: 20231215
DOI: 10.1002/anie.202115208
PMID: 34927320
قاعدة البيانات: MEDLINE
الوصف
تدمد:1521-3773
DOI:10.1002/anie.202115208