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The effect of long-acting injectable antipsychotic medications compared with oral antipsychotic medications among people with schizophrenia: A systematic review and meta-analysis.

التفاصيل البيبلوغرافية
العنوان: The effect of long-acting injectable antipsychotic medications compared with oral antipsychotic medications among people with schizophrenia: A systematic review and meta-analysis.
المؤلفون: Okoli CTC; University of Kentucky College of Nursing, Lexington, Kentucky, USA., Kappi A; University of Kentucky College of Nursing, Lexington, Kentucky, USA., Wang T; Department of Statistics, University of Kentucky College of Arts and Sciences, Lexington, Kentucky, USA., Makowski A; University of Kentucky College of Nursing, Lexington, Kentucky, USA., Cooley AT; University of Kentucky College of Medicine, Lexington, Kentucky, USA.
المصدر: International journal of mental health nursing [Int J Ment Health Nurs] 2022 Jun; Vol. 31 (3), pp. 469-535. Date of Electronic Publication: 2021 Dec 20.
نوع المنشور: Journal Article; Meta-Analysis; Review; Systematic Review
اللغة: English
بيانات الدورية: Publisher: Blackwell Pub Country of Publication: Australia NLM ID: 101140527 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1447-0349 (Electronic) Linking ISSN: 14458330 NLM ISO Abbreviation: Int J Ment Health Nurs
أسماء مطبوعة: Publication: Carlton, Vic. : Wiley-Blackwell : Blackwell Pub.
Original Publication: Carlton, Vic. : Blackwell Pub., c2002-
مواضيع طبية MeSH: Antipsychotic Agents*/therapeutic use , Schizophrenia*/drug therapy, Delayed-Action Preparations/therapeutic use ; Humans ; Prospective Studies ; Quality of Life ; Recurrence ; Retrospective Studies
مستخلص: Long-acting injectable (LAI) antipsychotic medications may be an important modality of reducing costs, improving symptoms, and fostering quality of life outcomes for those with schizophrenia. Our objective was to systematically review and conduct a meta-analysis of the effectiveness of LAIs compared with oral antipsychotics on medication adherence, symptom remission/relapse, rehospitalization, outpatient visits, emergency department visits, healthcare costs, and social functioning. We performed a systematic search of PsycInfo, CINAHL, PubMed, and Scopus databases to examine studies meeting inclusion criteria prior to August 30th, 2020. Randomized controlled trials, retrospective studies, prospective studies among people with schizophrenia with at least 6-month follow-up data were obtained. Overall effect sizes and associated 95% confidence intervals (CI) were estimated with random-effects modeling. We found 75 articles meeting our inclusion criteria, including 341 730 individuals with schizophrenia. Systematic review results indicated that LAIs compared with orals improved medication adherence (25/29 studies), symptom remission/relapse (10/18 studies), rehospitalizations (26/49 studies), emergency department visits (9/17 studies), medical costs (11/15 studies), and social functioning (5/9 studies); however, LAIs also increased outpatient visits (7/16 studies) and pharmacy costs (10/10 studies). Meta-analytic results of studies with similar outcome measures did not find differences between LAIs and orals in respect to outcomes, except lowering emergency department visits and increasing pharmacy costs. The differences between the results of the narrative synthesis and the meta-analyses were possibly because of the low availability of studies with similar outcomes in the pooled analyses. Our overall results suggest that LAIs are at least comparable to orals in supporting important healthcare outcomes for those with schizophrenia. These findings support clinical practice in encouraging providers to prescribe LAIs when indicated.
(© 2021 John Wiley & Sons Australia, Ltd.)
التعليقات: Erratum in: Int J Ment Health Nurs. 2023 Aug;32(4):1190. (PMID: 37226408)
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معلومات مُعتمدة: Kentucky Cabinet for Health and Family Services, Department of Medicaid Services
فهرسة مساهمة: Keywords: adherence; antipsychotic medications; healthcare utilization; rehospitalization; schizophrenia; symptom remission
المشرفين على المادة: 0 (Antipsychotic Agents)
0 (Delayed-Action Preparations)
تواريخ الأحداث: Date Created: 20211221 Date Completed: 20220516 Latest Revision: 20230525
رمز التحديث: 20240628
DOI: 10.1111/inm.12964
PMID: 34931437
قاعدة البيانات: MEDLINE
الوصف
تدمد:1447-0349
DOI:10.1111/inm.12964