التفاصيل البيبلوغرافية
| العنوان: |
Apoptotic effect of Bulbine Natalensis and Chlorophytum Comosum in myelogenous Leukemia K562 cell line. |
| المؤلفون: |
Padayachee B; Durban University of Technology - DUT, Department of Biotechnology and Food Technology, Steve Biko Campus, Durban, KwaZulu-Natal, South Africa., Odun-Ayo F; Cape Peninsula University of Technology - CPUT, Department of Biotechnology and Consumer Sciences, District Six Campus, Cape Town, Western Cape, South Africa., Reddy L; Cape Peninsula University of Technology - CPUT, Department of Biotechnology and Consumer Sciences, District Six Campus, Cape Town, Western Cape, South Africa. |
| المصدر: |
Brazilian journal of biology = Revista brasleira de biologia [Braz J Biol] 2021 Dec 20; Vol. 84, pp. e251336. Date of Electronic Publication: 2021 Dec 20 (Print Publication: 2021). |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: International Institute of Ecology Country of Publication: Brazil NLM ID: 101129542 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-4375 (Electronic) Linking ISSN: 15196984 NLM ISO Abbreviation: Braz J Biol Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: São Carlos, SP [Brazil] : International Institute of Ecology, [2000]- |
| مواضيع طبية MeSH: |
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/drug therapy , Asphodelaceae*, Apoptosis ; Humans ; K562 Cells |
| مستخلص: |
Bulbine natalensis and Chorophytum comosum are potential medicinal source for the treatment of cancers. Chronic myeloid leukaemia is a hematopoietic stem cells disorder treated by tyrosine kinase inhibitors but often cause recurrence of the leukaemia after cessation of therapy, hence require alternative treatment. This study determines the anti-cancer effect of leaf, root and bulb methanolic and aqueous extracts of B. natalensis and C. comosum in chronic human myelogenous leukaemia (K562) cell line by MTT, Hoechst bis-benzimide nuclear and annexin V stain assays. The root methanolic extract of B. natalensis and C. comosum showed a high cytotoxicity of 8.6% and 16.7% respectively on the K562 cell line at 1,000 μg/ml concentration. Morphological loss of cell membrane integrity causing degradation of the cell and fragmentation were observed in the root methanolic extract of both plants. A high apoptosis (p < 0.0001) was induced in the K562 cells by both leaf and root extracts of the C. comosum compared to the B. natalensis. This study shows both plants possess apoptotic effect against in vitro myelogenous leukaemia which contributes to the overall anti-cancer properties of B. natalensis and C. comosum to justify future therapeutic applications against chronic myelogenous leukaemia blood cancer. |
| تواريخ الأحداث: |
Date Created: 20211221 Date Completed: 20211223 Latest Revision: 20221207 |
| رمز التحديث: |
20231215 |
| DOI: |
10.1590/1519-6984.251336 |
| PMID: |
34932629 |
| قاعدة البيانات: |
MEDLINE |
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