دورية أكاديمية
أعرض في EDS

Poly I:C and STING agonist-primed DC increase lymphoid tissue polyfunctional HIV-1-specific CD8 + T cells and limit CD4 + T-cell loss in BLT mice.

التفاصيل البيبلوغرافية
العنوان: Poly I:C and STING agonist-primed DC increase lymphoid tissue polyfunctional HIV-1-specific CD8 + T cells and limit CD4 + T-cell loss in BLT mice.
المؤلفون: Calvet-Mirabent M; Immunology Unit, Instituto de Investigación Sanitaria Princesa, Hospital Universitario de la Princesa, Madrid, Spain.; Medicine Department, Universidad Autónoma of Madrid, Madrid, Spain., Claiborne DT; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA., Deruaz M; Human Immune System Mouse Program, Massachusetts General Hospital, Boston, Massachusetts, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA., Tanno S; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA.; Human Immune System Mouse Program, Massachusetts General Hospital, Boston, Massachusetts, USA., Serra C; Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Catalonia, Spain., Delgado-Arévalo C; Immunology Unit, Instituto de Investigación Sanitaria Princesa, Hospital Universitario de la Princesa, Madrid, Spain.; Medicine Department, Universidad Autónoma of Madrid, Madrid, Spain., Sánchez-Cerrillo I; Immunology Unit, Instituto de Investigación Sanitaria Princesa, Hospital Universitario de la Princesa, Madrid, Spain., de Los Santos I; Infectious Diseases Unit, Instituto de Investigación Sanitaria Princesa, Hospital Universitario de la Princesa, Madrid, Spain., Sanz J; Infectious Diseases Unit, Instituto de Investigación Sanitaria Princesa, Hospital Universitario de la Princesa, Madrid, Spain., García-Fraile L; Infectious Diseases Unit, Instituto de Investigación Sanitaria Princesa, Hospital Universitario de la Princesa, Madrid, Spain., Sánchez-Madrid F; Immunology Unit, Instituto de Investigación Sanitaria Princesa, Hospital Universitario de la Princesa, Madrid, Spain.; Medicine Department, Universidad Autónoma of Madrid, Madrid, Spain., Alfranca A; Immunology Unit, Instituto de Investigación Sanitaria Princesa, Hospital Universitario de la Princesa, Madrid, Spain., Muñoz-Fernández MÁ; Immunology Section, Instituto Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón, Madrid, Spain., Allen TM; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA., Buzón MJ; Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Catalonia, Spain., Balazs A; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA.; Human Immune System Mouse Program, Massachusetts General Hospital, Boston, Massachusetts, USA., Vrbanac V; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA.; Human Immune System Mouse Program, Massachusetts General Hospital, Boston, Massachusetts, USA., Martín-Gayo E; Immunology Unit, Instituto de Investigación Sanitaria Princesa, Hospital Universitario de la Princesa, Madrid, Spain.; Medicine Department, Universidad Autónoma of Madrid, Madrid, Spain.
المصدر: European journal of immunology [Eur J Immunol] 2022 Mar; Vol. 52 (3), pp. 447-461. Date of Electronic Publication: 2022 Jan 08.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 1273201 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4141 (Electronic) Linking ISSN: 00142980 NLM ISO Abbreviation: Eur J Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2005->: Weinheim : Wiley-VCH
Original Publication: Weinheim, Verlag Chemie GmbH.
مواضيع طبية MeSH: AIDS Vaccines*/metabolism , HIV-1*, Adjuvants, Immunologic/pharmacology ; Animals ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; Dendritic Cells ; HIV Core Protein p24/metabolism ; Lymphoid Tissue ; Mice ; Poly I-C/pharmacology
مستخلص: Effective function of CD8 + T cells and enhanced innate activation of DCs in response to HIV-1 is linked to protective antiviral immunity in controllers. Manipulation of DC targeting the master regulator TANK-binding Kinase 1 (TBK1) might be useful to acquire controller-like properties. Here, we evaluated the impact of the combination of 2´3´-c´diAM(PS)2 and Poly I:C as potential adjuvants capable of potentiating DC´s abilities to induce polyfunctional HIV-1 specific CD8 + T-cell responses in vitro and in vivo using a humanized BLT mouse model. Adjuvant combination enhanced TBK-1 phosphorylation and IL-12 and IFN-β expression on DC and increased their ability to activate polyfunctional HIV-1-specific CD8 + T cells in vitro. Moreover, higher proportions of hBLT mice vaccinated with ADJ-DC exhibited less severe CD4 + T-cell depletion following HIV-1 infection compared to control groups. This was associated with infiltration of CD8 + T cells in the white pulp from the spleen, reduced spread of infected p24 + cells to LN, and with preserved abilities of CD8 + T cells from the spleen and blood of vaccinated animals to induce specific polyfunctional responses upon antigen stimulation. Therefore, priming of DC with PolyI:C and STING agonists might be useful for future HIV-1 vaccine studies.
(© 2022 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.)
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معلومات مُعتمدة: R21 AI140930 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: CD8+ T cell; dendritic cell; hBLT mouse; lymphoid tissue; vaccine
المشرفين على المادة: 0 (AIDS Vaccines)
0 (Adjuvants, Immunologic)
0 (HIV Core Protein p24)
O84C90HH2L (Poly I-C)
تواريخ الأحداث: Date Created: 20211222 Date Completed: 20220505 Latest Revision: 20220505
رمز التحديث: 20240628
DOI: 10.1002/eji.202149502
PMID: 34935145
قاعدة البيانات: MEDLINE
الوصف
تدمد:1521-4141
DOI:10.1002/eji.202149502