Age-related Differences in Tumour Characteristics and Prognostic Factors for Disease Progression in Cutaneous Squamous Cell Carcinoma of the Head and Neck.

التفاصيل البيبلوغرافية
العنوان:	Age-related Differences in Tumour Characteristics and Prognostic Factors for Disease Progression in Cutaneous Squamous Cell Carcinoma of the Head and Neck.
المؤلفون:	Leus AJG; Department of Dermatology, University Medical Center Groningen, Hanzeplein 1, NL-9700 RB Groningen. The Netherlands. a.j.g.leus@umcg.nl., Haisma MS, Terra JB, Diercks GFH, Van Kester MS, Halmos GB, Rácz E, Van Dijk BAC, Plaat BEC
المصدر:	Acta dermato-venereologica [Acta Derm Venereol] 2022 Feb 22; Vol. 102, pp. adv00652. Date of Electronic Publication: 2022 Feb 22.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: MJS Publishing Country of Publication: Sweden NLM ID: 0370310 Publication Model: Electronic Cited Medium: Internet ISSN: 1651-2057 (Electronic) Linking ISSN: 00015555 NLM ISO Abbreviation: Acta Derm Venereol Subsets: MEDLINE
أسماء مطبوعة:	Publication: 2024- : Uppsala, Sweden : MJS Publishing Original Publication: Stockholm : Acta dermato-venereologica
مواضيع طبية MeSH:	Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/therapy , Head and Neck Neoplasms/pathology , Head and Neck Neoplasms/therapy , Skin Neoplasms*/pathology, Aged ; Disease Progression ; Humans ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck/pathology
مستخلص:	Guidelines for cutaneous squamous cell carcinoma of the head and neck do not take the age of the patient into account, but instead assume equal tumour characteristics and prognostic factors for poor outcome in younger and elderly patients. The aim of this study was to compare tumour characteristics of younger (< 75 years) and elderly (≥ 75 years) patients and identify age-specific risk factors for progression of disease, comprising local recurrence, nodal metastasis and distant metastasis. Patient and tumour characteristics were compared using χ2 or Fisher's exact tests. Multivariable competing risk analyses were performed to compare risk factors for progression of disease, incorporating the risk of dying before developing progression of disease. A total of 672 patients with primary cutaneous squamous cell carcinoma of the head and neck were retrospectively included. Larger tumour diameter, worse differentiation grade and deeper invasion were observed in older patients. In elderly patients, but not in younger patients, tumour diameter ≥ 40 mm, moderate differentiation grade and an invasion depth ≥ 2 mm were independent risk factors for progression of disease.
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تواريخ الأحداث:	Date Created: 20211222 Date Completed: 20220223 Latest Revision: 20230915
رمز التحديث:	20240628
مُعرف محوري في PubMed:	PMC9631266
DOI:	10.2340/actadv.v101.347
PMID:	34935990
قاعدة البيانات:	MEDLINE

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تدمد:	1651-2057
DOI:	10.2340/actadv.v101.347