دورية أكاديمية
أعرض في EDS

Is a negative correlation between sTNFR1 and TNF in patients with chronic Chagas disease the key to clinical progression?

التفاصيل البيبلوغرافية
العنوان: Is a negative correlation between sTNFR1 and TNF in patients with chronic Chagas disease the key to clinical progression?
المؤلفون: Torres DJL; Fundação Oswaldo Cruz-Fiocruz, Instituto Aggeu Magalhães, Laboratório de Imunoparasitologia, Recife, PE, Brazil., Arruda TR; Fundação Oswaldo Cruz-Fiocruz, Instituto Aggeu Magalhães, Laboratório de Imunoparasitologia, Recife, PE, Brazil., Barros MDS; Fundação Oswaldo Cruz-Fiocruz, Instituto Aggeu Magalhães, Laboratório de Imunoparasitologia, Recife, PE, Brazil., Gonçales JP; Universidade Federal de Pernambuco, Laboratório de Imunopatologia Keizo Asami, Laboratório de Virologia, Recife, PE, Brazil., Soares AKA; Fundação Altino Ventura - FAV, Recife, PE, Brazil., Oliveira KKDS; Fundação Oswaldo Cruz-Fiocruz, Instituto Aggeu Magalhães, Laboratório de Imunoparasitologia, Recife, PE, Brazil., Moreira LR; Fundação Oswaldo Cruz-Fiocruz, Instituto Aggeu Magalhães, Laboratório de Imunoparasitologia, Recife, PE, Brazil., Medeiros C; Ambulatório de Doença de Chagas e Insuficiência Cardíaca do Pronto Socorro Cardiológico de Pernambuco, Recife, PE, Brazil., Cavalcanti MDGAM; Ambulatório de Doença de Chagas e Insuficiência Cardíaca do Pronto Socorro Cardiológico de Pernambuco, Recife, PE, Brazil., Martins SM; Ambulatório de Doença de Chagas e Insuficiência Cardíaca do Pronto Socorro Cardiológico de Pernambuco, Recife, PE, Brazil., Carrazzone C; Ambulatório de Doença de Chagas e Insuficiência Cardíaca do Pronto Socorro Cardiológico de Pernambuco, Recife, PE, Brazil., Oliveira W; Ambulatório de Doença de Chagas e Insuficiência Cardíaca do Pronto Socorro Cardiológico de Pernambuco, Recife, PE, Brazil., Lannes-Vieira J; Fundação Oswaldo Cruz- Fiocruz, Instituto Oswaldo Cruz, Laboratório de Biologia das Interações, Rio de Janeiro, RJ, Brazil., Lorena VMB; Fundação Oswaldo Cruz-Fiocruz, Instituto Aggeu Magalhães, Laboratório de Imunoparasitologia, Recife, PE, Brazil. Electronic address: virginia.lorena@fiocruz.br.
المصدر: Immunobiology [Immunobiology] 2022 Jan; Vol. 227 (1), pp. 152166. Date of Electronic Publication: 2021 Dec 17.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8002742 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3279 (Electronic) Linking ISSN: 01712985 NLM ISO Abbreviation: Immunobiology Subsets: MEDLINE
أسماء مطبوعة: Publication: <2005->: Amsterdam : Elsevier
Original Publication: Stuttgart ; New York, Fischer.
مواضيع طبية MeSH: Chagas Disease*, Chronic Disease ; Cytokines ; Humans ; Receptors, Tumor Necrosis Factor
مستخلص: Soluble TNF receptors (sTNFR1 and sTNFR2) are natural endogenous inhibitors of TNF and are elevated in inflammatory, autoimmune, and chronic degenerative diseases. In Chagas disease, pleiotropic cytokine TNF is considered key in immunopathology. Thus, we aimed to evaluate the levels of TNF, sTNFR1, and sTNFR2 in the serum of patients with chronic Chagas disease. TNF and its soluble receptors were quantified using Cytometric Bead Array in the serum of 132 patients, of which 51 had the indeterminate form (IND), 39 the mild cardiac form (CARD 1), 42 the severe cardiac form (CARD 2), and 20 non-infected individuals (NI). The results indicate that the soluble receptors may regulate TNF in Chagas disease, as their leves were higher in T. cruzi-infected individuals when compared to non-infected individuals. We found a moderate negative correlation between sTNFR1 and TNF in individuals with the IND form, suggesting a relationship with non-progression to more severe forms, such as heart disease. sTNFR1 and sTNFR2 were increased in all clinical forms, but with a moderate positive correlation in more severe patients (r = 0.50 and p = 0.0005). TNF levels showed no statistical differences in the groups of patients. These findings suggest the importance of the endogenous balance of the levels of soluble TNF receptors in the protection and balance in patients with chronic Chagas disease, besides revealing the immunological complexity in chronic T. cruzi-infected individuals.
(Copyright © 2021. Published by Elsevier GmbH.)
فهرسة مساهمة: Keywords: Chagas cardiomyopathy; Chagas disease; TNF-alpha; TNFR1; TNFR2
المشرفين على المادة: 0 (Cytokines)
0 (Receptors, Tumor Necrosis Factor)
تواريخ الأحداث: Date Created: 20211222 Date Completed: 20220502 Latest Revision: 20220502
رمز التحديث: 20240628
DOI: 10.1016/j.imbio.2021.152166
PMID: 34936965
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-3279
DOI:10.1016/j.imbio.2021.152166