دورية أكاديمية
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A Novel C1q Domain-Containing Protein Isolated from the Mollusk Modiolus kurilensis Recognizing Glycans Enriched with Acidic Galactans and Mannans.

التفاصيل البيبلوغرافية
العنوان: A Novel C1q Domain-Containing Protein Isolated from the Mollusk Modiolus kurilensis Recognizing Glycans Enriched with Acidic Galactans and Mannans.
المؤلفون: Grinchenko AV; A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690041 Vladivostok, Russia., von Kriegsheim A; Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh EH4 2XU, UK., Shved NA; A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690041 Vladivostok, Russia.; Institute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia., Egorova AE; Institute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia., Ilyaskina DV; Institute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia., Karp TD; Institute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia., Goncharov NV; A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690041 Vladivostok, Russia.; Institute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia., Petrova IY; A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690041 Vladivostok, Russia., Kumeiko VV; A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690041 Vladivostok, Russia.; Institute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia.
المصدر: Marine drugs [Mar Drugs] 2021 Nov 26; Vol. 19 (12). Date of Electronic Publication: 2021 Nov 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2003]-
مواضيع طبية MeSH: Mollusca*, Membrane Glycoproteins/*genetics , Proteins/*genetics , Receptors, Complement/*genetics , Receptors, Pattern Recognition/*genetics, Animals ; Aquatic Organisms ; Humans ; Membrane Glycoproteins/chemistry ; Pacific Ocean ; Proteins/chemistry ; Receptors, Complement/chemistry ; Receptors, Pattern Recognition/chemistry
مستخلص: C1q domain-containing (C1qDC) proteins are a group of biopolymers involved in immune response as pattern recognition receptors (PRRs) in a lectin-like manner. A new protein MkC1qDC from the hemolymph plasma of Modiolus kurilensis bivalve mollusk widespread in the Northwest Pacific was purified. The isolation procedure included ammonium sulfate precipitation followed by affinity chromatography on pectin-Sepharose. The full-length MkC1qDC sequence was assembled using de novo mass-spectrometry peptide sequencing complemented with N-terminal Edman's degradation, and included 176 amino acid residues with molecular mass of 19 kDa displaying high homology to bivalve C1qDC proteins. MkC1qDC demonstrated antibacterial properties against Gram-negative and Gram-positive strains. MkC1qDC binds to a number of saccharides in Ca 2+ -dependent manner which characterized by structural meta-similarity in acidic group enrichment of galactose and mannose derivatives incorporated in diversified molecular species of glycans. Alginate, κ-carrageenan, fucoidan, and pectin were found to be highly effective inhibitors of MkC1qDC activity. Yeast mannan, lipopolysaccharide (LPS), peptidoglycan (PGN) and mucin showed an inhibitory effect at concentrations three orders of magnitude greater than for the most effective saccharides. MkC1qDC localized to the mussel hemal system and interstitial compartment. Intriguingly, MkC1qDC was found to suppress proliferation of human adenocarcinoma HeLa cells in a dose-dependent manner, indicating to the biomedical potential of MkC1qDC protein.
References: Cytotechnology. 2001 Jul;36(1-3):93-9. (PMID: 19003319)
Fish Shellfish Immunol. 2016 Nov;58:612-621. (PMID: 27725260)
Front Physiol. 2017 Jul 21;8:521. (PMID: 28785225)
Anal Biochem. 1976 May 7;72:248-54. (PMID: 942051)
BMC Genomics. 2013 Oct 29;14:741. (PMID: 24168212)
Fish Shellfish Immunol. 2012 Aug;33(2):427-35. (PMID: 22691582)
Dev Comp Immunol. 2011 Jun;35(6):635-43. (PMID: 21295069)
Fish Shellfish Immunol. 2008 Sep;25(3):281-9. (PMID: 18603000)
Fish Shellfish Immunol. 2011 Dec;31(6):1247-50. (PMID: 21906682)
Mar Drugs. 2019 Dec 21;18(1):. (PMID: 31877692)
Curr Protoc Immunol. 2001 May;Chapter 2:2.4.1-2.4.9. (PMID: 18432769)
J Biol Chem. 1994 Jun 3;269(22):15512-9. (PMID: 8195195)
Methods Mol Biol. 2010;588:15-26. (PMID: 20012814)
Comp Biochem Physiol B Biochem Mol Biol. 1997 Jun;117(2):273-86. (PMID: 9226886)
Nature. 1970 Aug 15;227(5259):680-5. (PMID: 5432063)
J Biol Chem. 1994 Jun 3;269(22):15505-11. (PMID: 8195194)
Sci Rep. 2016 Aug 26;6:31730. (PMID: 27562653)
Mar Drugs. 2019 Oct 14;17(10):. (PMID: 31615007)
Methods Mol Biol. 2015;1318:51-9. (PMID: 26160563)
Curr Pharm Biotechnol. 2020;21(14):1444-1450. (PMID: 32744967)
Eur J Biochem. 1986 Dec 1;161(2):359-73. (PMID: 3780748)
J Biochem. 2007 Mar;141(3):389-99. (PMID: 17234683)
Dev Comp Immunol. 2014 May;44(1):70-5. (PMID: 24296435)
Fish Shellfish Immunol. 2011 Apr-May;30(4-5):1202-6. (PMID: 21376125)
Curr Protoc Protein Sci. 2001 May;Appendix 3:Appendix 3F. (PMID: 18429073)
Dev Comp Immunol. 1998 Mar-Apr;22(2):139-50. (PMID: 9639084)
Mar Drugs. 2018 Apr 26;16(5):. (PMID: 29701680)
Mar Drugs. 2014 Jun 30;12(7):3994-4004. (PMID: 24983642)
Fish Shellfish Immunol. 2016 Aug;55:323-31. (PMID: 27288256)
Anal Chem. 2007 Aug 1;79(15):5698-702. (PMID: 17580952)
Fish Shellfish Immunol. 2014 Nov;41(1):2-11. (PMID: 24882017)
Fish Shellfish Immunol. 2016 Feb;49:163-76. (PMID: 26690665)
Zoological Lett. 2016 Feb 18;2:3. (PMID: 26900483)
Fish Shellfish Immunol. 2012 Jun;32(6):1106-16. (PMID: 22484279)
Fish Shellfish Immunol. 2020 Nov;106:621-627. (PMID: 32827655)
Dev Comp Immunol. 2010 Aug;34(8):837-46. (PMID: 20346969)
Sci Rep. 2021 Jan 13;11(1):1105. (PMID: 33441832)
Ecology. 2017 Jun;98(6):1710-1721. (PMID: 28376248)
Protein Sci. 2018 Jan;27(1):135-145. (PMID: 28884485)
Biochim Biophys Acta. 2002 Sep 19;1572(2-3):187-97. (PMID: 12223269)
Fish Shellfish Immunol. 2012 Apr;32(4):578-85. (PMID: 22281611)
Mar Drugs. 2017 Mar 14;15(3):. (PMID: 28335432)
Methods Mol Biol. 2014;1200:555-77. (PMID: 25117264)
Appl Microbiol Biotechnol. 2015 May;99(9):3755-73. (PMID: 25794876)
Dev Comp Immunol. 2010 Sep;34(9):926-34. (PMID: 20219531)
PLoS One. 2012;7(8):e43289. (PMID: 22905248)
Int J Mol Sci. 2018 Mar 03;19(3):. (PMID: 29510476)
Insect Biochem Mol Biol. 1999 Jul;29(7):585-97. (PMID: 10436935)
Biology (Basel). 2014 Apr 16;3(2):320-32. (PMID: 24833512)
J Invertebr Pathol. 2016 Oct;140:25-34. (PMID: 27469189)
Nat Ecol Evol. 2017 Apr 03;1(5):121. (PMID: 28812709)
Fish Shellfish Immunol. 2015 Aug;45(2):583-91. (PMID: 26002640)
Genome Biol Evol. 2017 Jun 1;9(6):1487-1498. (PMID: 28505302)
Int J Pharm. 2010 Apr 15;389(1-2):157-67. (PMID: 20100554)
Eur J Biochem. 1967 Mar;1(1):80-91. (PMID: 6059350)
Histochem Cell Biol. 2017 Feb;147(2):223-237. (PMID: 27999992)
Cancer Metastasis Rev. 1987;5(3):185-204. (PMID: 3549035)
J Proteome Res. 2008 Apr;7(4):1693-703. (PMID: 18311904)
Dev Comp Immunol. 2015 Oct;52(2):202-14. (PMID: 26049063)
Cell Mol Life Sci. 2021 Jul;78(14):5569-5585. (PMID: 34089345)
DNA Res. 2018 Dec 1;25(6):655-665. (PMID: 30295708)
Dev Comp Immunol. 2015 Mar;49(1):59-71. (PMID: 25445912)
معلومات مُعتمدة: 0657-2020-0004 Ministry of Science and Higher Education of the Russian Federation; 121082600034-5 Ministry of Science and Higher Education of the Russian Federation
فهرسة مساهمة: Keywords: C1q domain-containing; bivalve mollusk; interstitial compartment; lectin-like; pattern recognition receptor; polysaccharides
المشرفين على المادة: 0 (Membrane Glycoproteins)
0 (Proteins)
0 (Receptors, Complement)
0 (Receptors, Pattern Recognition)
0 (complement 1q receptor)
تواريخ الأحداث: Date Created: 20211223 Date Completed: 20220124 Latest Revision: 20240404
رمز التحديث: 20240404
مُعرف محوري في PubMed: PMC8706970
DOI: 10.3390/md19120668
PMID: 34940667
قاعدة البيانات: MEDLINE
الوصف
تدمد:1660-3397
DOI:10.3390/md19120668