دورية أكاديمية
أعرض في EDS

Low-Molecular-Weight Seaweed-Derived Polysaccharides Lead to Increased Faecal Bulk but Do Not Alter Human Gut Health Markers.

التفاصيل البيبلوغرافية
العنوان: Low-Molecular-Weight Seaweed-Derived Polysaccharides Lead to Increased Faecal Bulk but Do Not Alter Human Gut Health Markers.
المؤلفون: Bannon CD; The Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, Co., Londonderry BT52 1SA, Northern Ireland, UK., Eckenberger J; School of Microbiology and APC Microbiome Ireland, University College Cork, T12 K8AF Cork, Ireland., Snelling WJ; The Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, Co., Londonderry BT52 1SA, Northern Ireland, UK., Huseyin CE; School of Microbiology and APC Microbiome Ireland, University College Cork, T12 K8AF Cork, Ireland., Allsopp P; The Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, Co., Londonderry BT52 1SA, Northern Ireland, UK., Strain C; Moorepark Food Research Centre, Teagasc, Fermoy, Co., P61 C966 Cork, Ireland., Ramnani P; Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, UK., Chitarrari R; Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, UK., Grant J; Kerry Global Technology and Innovation Centre, Millennium Park, Naas, Co., W91 W923 Kildare, Ireland., Hotchkiss S; CyberColloids Ltd., Carrigaline Industrial Estate, Carrigaline, Co., P43 VR72 Cork, Ireland., Philp K; CyberColloids Ltd., Carrigaline Industrial Estate, Carrigaline, Co., P43 VR72 Cork, Ireland., Campbell R; CyberColloids Ltd., Carrigaline Industrial Estate, Carrigaline, Co., P43 VR72 Cork, Ireland., Tuohy KM; Nutrition and Nutrigenomics Unit, Research and Innovation Centre, Fondazione Edmund Mach, Via E. Mach 1, 38098 S. Michele all'Adige, TN, Italy., Claesson MJ; School of Microbiology and APC Microbiome Ireland, University College Cork, T12 K8AF Cork, Ireland., Ternan NG; The Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, Co., Londonderry BT52 1SA, Northern Ireland, UK., Dooley JSG; The Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, Co., Londonderry BT52 1SA, Northern Ireland, UK., Sleator RD; Department of Biological Sciences, Munster Technological University, Bishopstown, T12 P928 Cork, Ireland., Rowland I; Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, UK., Gill CIR; The Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, Co., Londonderry BT52 1SA, Northern Ireland, UK.
المصدر: Foods (Basel, Switzerland) [Foods] 2021 Dec 03; Vol. 10 (12). Date of Electronic Publication: 2021 Dec 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101670569 Publication Model: Electronic Cited Medium: Print ISSN: 2304-8158 (Print) Linking ISSN: 23048158 NLM ISO Abbreviation: Foods Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2012]-
مستخلص: Seaweeds are potentially sustainable crops and are receiving significant interest because of their rich bioactive compound content; including fatty acids, polyphenols, carotenoids, and complex polysaccharides. However, there is little information on the in vivo effects on gut health of the polysaccharides and their low-molecular-weight derivatives. Herein, we describe the first investigation into the prebiotic potential of low-molecular-weight polysaccharides (LMWPs) derived from alginate and agar in order to validate their in vivo efficacy. We conducted a randomized; placebo-controlled trial testing the impact of alginate and agar LWMPs on faecal weight and other markers of gut health and on composition of gut microbiota. We show that these LMWPs led to significantly increased faecal bulk (20-30%). Analysis of gut microbiome composition by sequencing indicated no significant changes attributable to treatment at the phylum and family level, although FISH analysis showed an increase in Faecalibacterium prausnitzii in subjects consuming agar LMWP. Sequence analysis of gut bacteria corroborated with the FISH data, indicating that alginate and agar LWMPs do not alter human gut microbiome health markers. Crucially, our findings suggest an urgent need for robust and rigorous human in vivo testing-in particular, using refined seaweed extracts.
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معلومات مُعتمدة: 222470 European Union
فهرسة مساهمة: Keywords: bacteriome; faecal bulk; health benefits; seaweed
تواريخ الأحداث: Date Created: 20211224 Latest Revision: 20211229
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8701010
DOI: 10.3390/foods10122988
PMID: 34945540
قاعدة البيانات: MEDLINE
الوصف
تدمد:2304-8158
DOI:10.3390/foods10122988