دورية أكاديمية
Mipsagargin: The Beginning-Not the End-of Thapsigargin Prodrug-Based Cancer Therapeutics.
العنوان: | Mipsagargin: The Beginning-Not the End-of Thapsigargin Prodrug-Based Cancer Therapeutics. |
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المؤلفون: | Isaacs JT; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center (SKCCC), Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Brennen WN; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center (SKCCC), Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Christensen SB; Department of Drug Design and Pharmacology, University of Copenhagen, DK-2100 Copenhagen, Denmark., Denmeade SR; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center (SKCCC), Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. |
المصدر: | Molecules (Basel, Switzerland) [Molecules] 2021 Dec 09; Vol. 26 (24). Date of Electronic Publication: 2021 Dec 09. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c1995- |
مواضيع طبية MeSH: | Antineoplastic Agents*/pharmacokinetics , Antineoplastic Agents*/therapeutic use , Prodrugs*/pharmacokinetics , Prodrugs*/therapeutic use , Thapsigargin*/pharmacokinetics , Thapsigargin*/therapeutic use, Neoplasm Proteins/*metabolism , Neoplasms/*drug therapy , Neoplasms/*metabolism, Animals ; Clinical Trials, Phase II as Topic ; Humans |
مستخلص: | Søren Brøgger Christensen isolated and characterized the cell-penetrant sesquiterpene lactone Thapsigargin (TG) from the fruit Thapsia garganica. In the late 1980s/early 1990s, TG was supplied to multiple independent and collaborative groups. Using this TG, studies documented with a large variety of mammalian cell types that TG rapidly (i.e., within seconds to a minute) penetrates cells, resulting in an essentially irreversible binding and inhibiting (IC |
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معلومات مُعتمدة: | P30 CA006973 United States CA NCI NIH HHS; CA58236 Defense Cancer Research Program award DAMD17-00-1-0028 to SRD |
فهرسة مساهمة: | Keywords: Mipsagargin; SERCA; Thapsia garganica; Thapsigargin; apoptosis; calcium homeostasis; targeted prodrugs; tissue-specific proteases |
المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Neoplasm Proteins) 0 (Prodrugs) 67526-95-8 (Thapsigargin) |
تواريخ الأحداث: | Date Created: 20211224 Date Completed: 20220211 Latest Revision: 20240820 |
رمز التحديث: | 20240820 |
مُعرف محوري في PubMed: | PMC8707208 |
DOI: | 10.3390/molecules26247469 |
PMID: | 34946547 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1420-3049 |
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DOI: | 10.3390/molecules26247469 |