دورية أكاديمية
أعرض في EDS

Nanogold Particles Suppresses 5-Flurouracil-Induced Renal Injury: An Insight into the Modulation of Nrf-2 and Its Downstream Targets, HO-1 and γ-GCS.

التفاصيل البيبلوغرافية
العنوان: Nanogold Particles Suppresses 5-Flurouracil-Induced Renal Injury: An Insight into the Modulation of Nrf-2 and Its Downstream Targets, HO-1 and γ-GCS.
المؤلفون: El-Sherbiny M; Department of Basic Medical Sciences, College of Medicine, Almaarefa University, P.O. Box 71666, Riyadh 11597, Saudi Arabia.; Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt., Fahmy EK; Medical Physiology Department, College of Medicine, Zagazig University, Zagazig 44519, Egypt.; Medical Physiology Department, Faculty of Medicine, Northern Border University, Arar 91431, Saudi Arabia., Eisa NH; Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt., Said E; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.; Faculty of Pharmacy, New Mansoura University, New Mansoura 7723730, Egypt., Elkattawy HA; Department of Basic Medical Sciences, College of Medicine, Almaarefa University, P.O. Box 71666, Riyadh 11597, Saudi Arabia.; Medical Physiology Department, College of Medicine, Zagazig University, Zagazig 44519, Egypt.; Zagazig Obesity Management & Research Unit, College of Medicine, Zagazig University, Zagazig 44519, Egypt., Ebrahim HA; Department of Basic Medical Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia., Elsherbiny NM; Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia., Ghoneim FM; Histology and Cell Biology Department, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2021 Dec 19; Vol. 26 (24). Date of Electronic Publication: 2021 Dec 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Fluorouracil/*antagonists & inhibitors , Gold/*pharmacology , Kidney/*drug effects , Metal Nanoparticles/*chemistry, Animals ; Disease Models, Animal ; Fluorouracil/administration & dosage ; Fluorouracil/pharmacology ; Gold/administration & dosage ; Gold/chemistry ; Heme Oxygenase (Decyclizing)/antagonists & inhibitors ; Heme Oxygenase (Decyclizing)/metabolism ; Injections, Intraperitoneal ; Kidney/injuries ; Kidney/pathology ; Metal Nanoparticles/administration & dosage ; NF-E2-Related Factor 2/antagonists & inhibitors ; NF-E2-Related Factor 2/metabolism ; Nanotechnology ; Particle Size ; Rats ; Rats, Sprague-Dawley ; gamma-Glutamylcyclotransferase/antagonists & inhibitors ; gamma-Glutamylcyclotransferase/metabolism
مستخلص: The development of the field of nanotechnology has revolutionized various aspects in the fields of modern sciences. Nano-medicine is one of the primary fields for the application of nanotechnology techniques. The current study sheds light on the reno-protective impacts of gold nano-particles; nanogold (AuNPs) against 5-flurouracil (5-FU)-induced renal toxicity. Indeed, the use of 5-FU has been associated with kidney injury which greatly curbs its therapeutic application. In the current study, 5-FU injection was associated with a significant escalation in the indices of renal injury, i.e., creatinine and urea. Alongside this, histopathological and ultra-histopathological changes confirmed the onset of renal injury. Both gene and/or protein expression of nuclear factor erythroid 2-related factor 2 (Nrf-2) and downstream antioxidant enzymes revealed consistent paralleled anomalies. AuNPs administration induced a significant renal protection on functional, biochemical, and structural levels. Renal expression of the major sensor of the cellular oxidative status Nrf-2 escalated with a paralleled reduction in the renal expression of the other contributor to this axis, known as Kelch-like ECH-associated protein 1 (Keap-1). On the level of the effector downstream targets, heme oxygenase 1 (HO-1) and gamma-glutamylcysteine synthetase (γ-GCS) AuNPs significantly restored their gene and protein expression. Additionally, combination of AuNPs with 5-FU showed better cytotoxic effect on MCF-7 cells compared to monotreatments. Thus, it can be inferred that AuNPs conferred reno-protective impact against 5-FU with an evident modulatory impact on Nrf-2/Keap-1 and its downstream effectors, HO-1 and γ-GCS, suggesting its potential use in 5-FU regimens to improve its therapeutic outcomes and minimize its underlying nephrotoxicity.
References: Biophys Rev. 2017 Feb;9(1):41-56. (PMID: 28510041)
Folia Morphol (Warsz). 2017;76(4):608-619. (PMID: 28553862)
Environ Sci Pollut Res Int. 2021 Sep;28(34):47046-47055. (PMID: 33886055)
Eur Cytokine Netw. 2016 Mar 1;27(1):6-15. (PMID: 27094155)
Oncol Lett. 2012 Dec;4(6):1247-1253. (PMID: 23205122)
Drug Deliv Transl Res. 2020 Feb;10(1):216-226. (PMID: 31637677)
Pharmacol Rev. 2008 Mar;60(1):79-127. (PMID: 18323402)
Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):22639-22648. (PMID: 32900936)
Cell Death Dis. 2018 May 23;9(6):610. (PMID: 29795190)
Pharm Nanotechnol. 2019;7(5):389-403. (PMID: 31465287)
Antioxid Redox Signal. 2007 Jan;9(1):49-89. (PMID: 17115887)
Exp Toxicol Pathol. 2017 Jun 14;69(5):265-274. (PMID: 28189472)
Molecules. 2017 May 06;22(5):. (PMID: 28481246)
Rev Col Bras Cir. 2018 Oct 18;45(5):e1968. (PMID: 30379218)
Int J Mol Sci. 2017 May 17;18(5):. (PMID: 28513573)
Hum Exp Toxicol. 2016 Jan;35(1):10-20. (PMID: 25724421)
Environ Toxicol Pharmacol. 2020 Nov;80:103494. (PMID: 32942000)
Neurotoxicology. 2021 Jan;82:167-176. (PMID: 33352273)
Arch Med Res. 2020 Jul;51(5):388-396. (PMID: 32409143)
Biosci Biotechnol Biochem. 2010;74(11):2209-13. (PMID: 21071867)
Toxicol Rep. 2015 Jun 15;2:908-916. (PMID: 28962429)
Curr Opin Nephrol Hypertens. 2011 Jan;20(1):7-15. (PMID: 21099687)
Iran J Basic Med Sci. 2018 Apr;21(4):404-410. (PMID: 29796225)
Ther Adv Med Oncol. 2018 Jun 18;10:1758835918780140. (PMID: 29977352)
Gene. 2019 Apr 5;691:8-17. (PMID: 30594636)
Food Chem Toxicol. 2014 Apr;66:185-93. (PMID: 24486618)
Int J Nanomedicine. 2018 Mar 15;13(T-NANO 2014 Abstracts):31-33. (PMID: 30880955)
J Pharm Pharmacol. 2017 Aug;69(8):1002-1009. (PMID: 28471000)
Nano Lett. 2021 Jul 14;21(13):5850-5858. (PMID: 34156251)
Nat Rev Nephrol. 2016 Dec;12(12):738-753. (PMID: 27795549)
J Nanobiotechnology. 2010 Jul 14;8:16. (PMID: 20630072)
Pharmaceutics. 2020 Mar 27;12(4):. (PMID: 32230975)
J Amino Acids. 2012;2012:736837. (PMID: 22500213)
Int J Mol Sci. 2018 Jul 06;19(7):. (PMID: 29986450)
Cytokine. 2016 Jan;77:26-34. (PMID: 26517155)
Front Chem. 2019 Apr 05;7:167. (PMID: 31024882)
J Immunol. 2004 Mar 15;172(6):3553-63. (PMID: 15004156)
Eur J Pharmacol. 2021 Jan 15;891:173671. (PMID: 33131720)
Front Pharmacol. 2016 Jun 23;7:172. (PMID: 27445811)
J Pharm Pharm Sci. 2011;14(1):67-77. (PMID: 21501554)
Mol Biol Rep. 2021 Dec;48(12):7733-7742. (PMID: 34637097)
Int J Mol Sci. 2020 Oct 15;21(20):. (PMID: 33076548)
Res Vet Sci. 2019 Jun;124:32-37. (PMID: 30807910)
Chem Biol Interact. 2014 Nov 5;223:102-8. (PMID: 25268985)
Free Radic Biol Med. 2009 Nov 1;47(9):1304-9. (PMID: 19666107)
Biomed Pharmacother. 2018 Oct;106:910-916. (PMID: 30119262)
Front Oncol. 2021 Aug 16;11:720620. (PMID: 34485154)
Oxid Med Cell Longev. 2017;2017:8416763. (PMID: 28819546)
Int J Nanomedicine. 2015 Sep 21;10:5925-39. (PMID: 26445536)
Toxicology. 2008 Apr 3;246(1):24-33. (PMID: 18083283)
Phytomedicine. 2022 Jan;94:153844. (PMID: 34785413)
Autoimmunity. 1988;1(4):275-83. (PMID: 2979622)
Biochem Cell Biol. 2015 Dec;93(6):548-57. (PMID: 26583437)
J Pharm Pharmacol. 2020 Nov;72(11):1546-1555. (PMID: 32746497)
Free Radic Biol Med. 2004 May 15;36(10):1199-207. (PMID: 15110384)
Nat Commun. 2021 Aug 10;12(1):4840. (PMID: 34376661)
Free Radic Res. 2007 Jun;41(6):615-26. (PMID: 17516233)
Environ Sci Pollut Res Int. 2021 Jan;28(4):4558-4572. (PMID: 32946057)
معلومات مُعتمدة: PNURSP2022R171 Princess Nourah bint Abdulrahman University
فهرسة مساهمة: Keywords: 5-flurouracil; Nrf-2; nanogold
المشرفين على المادة: 0 (NF-E2-Related Factor 2)
0 (Nfe2l2 protein, rat)
7440-57-5 (Gold)
EC 1.14.14.18 (Heme Oxygenase (Decyclizing))
EC 1.14.14.18 (Hmox1 protein, rat)
EC 4.3.2.9 (gamma-Glutamylcyclotransferase)
U3P01618RT (Fluorouracil)
تواريخ الأحداث: Date Created: 20211224 Date Completed: 20220214 Latest Revision: 20220214
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8707269
DOI: 10.3390/molecules26247684
PMID: 34946766
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules26247684