دورية أكاديمية
Immune-Enhancing Effects of Crude Polysaccharides from Korean Ginseng Berries on Spleens of Mice with Cyclophosphamide-Induced Immunosuppression.
| العنوان: | Immune-Enhancing Effects of Crude Polysaccharides from Korean Ginseng Berries on Spleens of Mice with Cyclophosphamide-Induced Immunosuppression. |
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| المؤلفون: | Nam JH; Department of Wellness-Bio Industry, Gangneung-Wonju National University, Gangneung 25457, Republic of Korea., Choi J; Department of Wellness-Bio Industry, Gangneung-Wonju National University, Gangneung 25457, Republic of Korea., Monmai C; Department of Marine Food Science and Technology, Gangneung-Wonju National University, Gangneung 25457, Republic of Korea., Rod-In W; Department of Marine Food Science and Technology, Gangneung-Wonju National University, Gangneung 25457, Republic of Korea., Jang AY; Department of Wellness-Bio Industry, Gangneung-Wonju National University, Gangneung 25457, Republic of Korea., You S; Department of Wellness-Bio Industry, Gangneung-Wonju National University, Gangneung 25457, Republic of Korea.; Department of Marine Food Science and Technology, Gangneung-Wonju National University, Gangneung 25457, Republic of Korea., Park WJ; Department of Wellness-Bio Industry, Gangneung-Wonju National University, Gangneung 25457, Republic of Korea.; Department of Marine Food Science and Technology, Gangneung-Wonju National University, Gangneung 25457, Republic of Korea. |
| المصدر: | Journal of microbiology and biotechnology [J Microbiol Biotechnol] 2022 Feb 28; Vol. 32 (2), pp. 256-262. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Society for Microbiology and Biotechnology Country of Publication: Korea (South) NLM ID: 9431852 Publication Model: Print Cited Medium: Internet ISSN: 1738-8872 (Electronic) Linking ISSN: 10177825 NLM ISO Abbreviation: J Microbiol Biotechnol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2002- : Seoul : Korean Society for Microbiology and Biotechnology Original Publication: Seoul : Korean Society for Applied Microbiology, 1991-2001. |
| مواضيع طبية MeSH: | Panax*, Animals ; Cyclophosphamide/adverse effects ; Fruit ; Immunosuppression Therapy ; Mice ; Mice, Inbred BALB C ; Polysaccharides/pharmacology ; Spleen |
| مستخلص: | Panax ginseng C. A. Meyer is well known as traditional herbal medicine, and ginseng berries are known to exhibit potential immune-enhancing functions. However, little is known about the in vivo immunomodulatory activity of Korean ginseng berries. In this study, crude Korean ginseng berries polysaccharides (GBP) were isolated and their immunomodulatory activities were investigated using cyclophosphamide (CY)-induced immunosuppressive BALB/c mice. In CY-treated mice, oral administration of GBP (50-500 mg/kg BW) remarkably increased their spleen sizes and spleen indices and activated NK cell activities. GBP also resulted in the proliferation of splenic lymphocytes (coordinating with ConA: plant mitogen which is known to stimulate T-cell or LPS: endotoxin which binds receptor complex in B cells to promote the secretion of pro-inflammatory cytokines) in a dose-dependent manner. In addition, GBP significantly stimulated mRNA expression levels of immune-associated genes including interleukin-1β ( IL-1β ), IL-2 , IL-4 , IL-6 , tumor necrosis factor-α ( TNF-α ), interferon-γ ( IFN-γ ), toll-like receptor 4 ( TLR-4 ), and cyclooxygenase-2 ( COX-2 ) in CY-treated mice. These results indicate that GBP is involved in immune effects against CY-induced immunosuppression. Thus, GBP could be developed as an immunomodulation agent for medicinal or functional food application. |
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| فهرسة مساهمة: | Keywords: Korean ginseng berry; cyclophosphamide; immune-enhancing effect; polysaccharides |
| المشرفين على المادة: | 0 (Polysaccharides) 8N3DW7272P (Cyclophosphamide) |
| تواريخ الأحداث: | Date Created: 20211224 Date Completed: 20220316 Latest Revision: 20221214 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9628850 |
| DOI: | 10.4014/jmb.2110.10021 |
| PMID: | 34949747 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1738-8872 |
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| DOI: | 10.4014/jmb.2110.10021 |