دورية أكاديمية
Isoniazid preventive therapy in child household contacts of adults with active TB in Bamako, Mali.
| العنوان: | Isoniazid preventive therapy in child household contacts of adults with active TB in Bamako, Mali. |
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| المؤلفون: | Tolofoudie M; University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Somboro A; University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Diarra B; University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Sarro YS; University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Drame HB; University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Togo ACG; University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Sanogo M; University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Dembele A; Department of Paediatrics, University Teaching Hospital of Gabriel Toure, Bamako, Mali., Togun T; Vaccines and Immunity Theme, Medical Research Council Unit-The Gambia, Banjul, The Gambia., Nkereuwem E; Vaccines and Immunity Theme, Medical Research Council Unit-The Gambia, Banjul, The Gambia., Baya B; University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Konate B; National Tuberculosis Control Program, Ministry of Health and Public Hygiene, Bamako, Mali., Egere U; Vaccines and Immunity Theme, Medical Research Council Unit-The Gambia, Banjul, The Gambia., Traore M; Health Referral Center Five, Ministry of Health and Social Development, Bamako, Mali., Maiga M; Center for Innovation in Global Health Technology, Northwestern University, Chicago, IL, USA., Saliba-Shaw K; Collaborative Clinical Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases/National Institutes of Health, Bethesda, MD, USA., Kampmann B; Vaccines and Immunity Theme, Medical Research Council Unit-The Gambia, Banjul, The Gambia., Diallo S; University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Doumbia S; University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Sylla M; Department of Paediatrics, University Teaching Hospital of Gabriel Toure, Bamako, Mali. |
| المصدر: | Public health action [Public Health Action] 2021 Dec 21; Vol. 11 (4), pp. 191-195. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: International Union Against Tuberculosis and Lung Disease Country of Publication: France NLM ID: 101624961 Publication Model: Print Cited Medium: Print ISSN: 2220-8372 (Print) Linking ISSN: 22208372 NLM ISO Abbreviation: Public Health Action Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Paris : International Union Against Tuberculosis and Lung Disease |
| مستخلص: | Background and Objective: Isoniazid preventive therapy (IPT) is known to reduce the risk of developing active TB in about 59% in children aged ⩽15 years. We assessed adherence, completion and adverse events among children who were household contacts of a newly diagnosed adult with smear-positive TB in Bamako, Mali. Methods: Children aged <15 years living in the same house with an adult smear-positive index case were enrolled in the study in the Bamako Region after consent was obtained from the parent or legal guardian. Adherence was assessed based on the number of tablets consumed during 6 months. Results: A total of 260 children aged <15 years were identified as household contacts of 207 adult patients with smear-positive TB during the study period. Among all child contacts, 130/260 (50.0%) were aged 0-4 years and were eligible for IPT; 128/130 (98.5%) were started on IPT and 83/128 (64.8%) completed with good adherence at the end of the 6 months, and without any significant adverse events. Conclusion: We successfully implemented IPT with good acceptance, but low completion rate. The Mali National TB Program and partners should expand this strategy to reach more children in Bamako and the whole country and create greater awareness in the population. Competing Interests: The work was partially funded by the Medical Research Council-Global Challenges Research Fund through the ‘Reach4Kids Africa’ project in collaboration with the Mali NTP; BD was partially supported by National Institutes of Health, Bethesda, MD, USA (C-THANU54EB027049). Conflicts of interest: none declared. (© 2021 The Union.) |
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| معلومات مُعتمدة: | D43 TW008652 United States TW FIC NIH HHS; U54 EB027049 United States EB NIBIB NIH HHS |
| فهرسة مساهمة: | Keywords: Bamako; IPT; Mali; childhood TB Local Abstract: [Publisher, French] Le traitement préventif par isoniazide (IPT) réduit le risque de développer une TB active chez environ 59% des enfants ⩽15 ans. Nous avons évalué l’observance, l’achèvement du traitement et les évènements indésirables chez des enfants qui étaient contacts domestiques d’un adulte ayant récemment reçu un diagnostic de TB à microscopie positive à Bamako, Mali. [Publisher, French] Les enfants âgés <15 ans vivant sous le même toit qu’un cas index adulte de TB à microscopie positive ont été inclus dans l’étude dans la région de Bamako, après obtention du consentement des parents ou du tuteur légal. L’observance a été évaluée en fonction du nombre de comprimés consommés au cours d’une période de 6 mois. [Publisher, French] Au total, 260 enfants âgés <15 ans ont été identifiés comme contacts domestiques de 207 patients adultes atteints de TB à microscopie positive pendant la période d’étude. Parmi tous les contacts pédiatriques, 130/260 (50,0%) étaient âgés de 0–4 ans et étaient éligibles à l’IPT ; 128/130 (98,5%) ont été mis sous IPT et 83/128 (64,8%) ont achevé leur traitement avec une bonne observance à la fin de la période de 6 mois, sans évènement indésirable significatif. [Publisher, French] Nous avons mis en place l’ITP avec succès. L’acceptation était bonne mais le taux d’achèvement du traitement était faible. Le programme national de lutte contre la TB du Mali et ses partenaires devraient élargir cette stratégie afin d’inclure davantage d’enfants de Bamako et du pays, et d’accroître la sensibilisation de la population. |
| تواريخ الأحداث: | Date Created: 20211227 Latest Revision: 20240404 |
| رمز التحديث: | 20240404 |
| مُعرف محوري في PubMed: | PMC8680184 |
| DOI: | 10.5588/pha.21.0061 |
| PMID: | 34956847 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2220-8372 |
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| DOI: | 10.5588/pha.21.0061 |