دورية أكاديمية
أعرض في EDS

COVID-19 Outcome Relates With Circulating BDNF, According to Patient Adiposity and Age.

التفاصيل البيبلوغرافية
العنوان: COVID-19 Outcome Relates With Circulating BDNF, According to Patient Adiposity and Age.
المؤلفون: Minuzzi LG; Exercise and Immunometabolism Research Group, Postgraduation Program in Movement Sciences, Department of Physical Education, Universidade Estadual Paulista (UNESP), Presidente Prudente, Brazil., Seelaender M; Cancer Metabolism Research Group, LIM26-HC, FMUSP, University of São Paulo, São Paulo, Brazil., Silva BSA; Exercise and Immunometabolism Research Group, Postgraduation Program in Movement Sciences, Department of Physical Education, Universidade Estadual Paulista (UNESP), Presidente Prudente, Brazil., Cunha EDBB; Graduate Program in Health Sciences, School of Medicine, Pontificia Universidade Catolica do Parana, Curitiba, Brazil., Deus MC; Graduate Program in Health Sciences, School of Medicine, Pontificia Universidade Catolica do Parana, Curitiba, Brazil., Vasconcellos FTF; Graduate Program in Health Sciences, School of Medicine, Pontificia Universidade Catolica do Parana, Curitiba, Brazil., Marqueze LFB; Graduate Program in Health Sciences, School of Medicine, Pontificia Universidade Catolica do Parana, Curitiba, Brazil., Gadotti AC; Graduate Program in Health Sciences, School of Medicine, Pontificia Universidade Catolica do Parana, Curitiba, Brazil., Baena CP; Graduate Program in Health Sciences, School of Medicine, Pontificia Universidade Catolica do Parana, Curitiba, Brazil., Pereira T; Polytechnic Institute of Coimbra, Coimbra Health School, Coimbra, Portugal.; Laboratory for Applied Health Research (LabinSaúde), Coimbra, Portugal., Krüger K; Department of Exercise Physiology and Sports Therapy, Institute of Sports Science, Justus-Liebig-University Giessen, Giessen, Germany., Amaral ANM; Graduate Program in Health Sciences, School of Medicine, Pontificia Universidade Catolica do Parana, Curitiba, Brazil., Pinho RA; Graduate Program in Health Sciences, School of Medicine, Pontificia Universidade Catolica do Parana, Curitiba, Brazil., Lira FS; Exercise and Immunometabolism Research Group, Postgraduation Program in Movement Sciences, Department of Physical Education, Universidade Estadual Paulista (UNESP), Presidente Prudente, Brazil.
المصدر: Frontiers in nutrition [Front Nutr] 2021 Dec 10; Vol. 8, pp. 784429. Date of Electronic Publication: 2021 Dec 10 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S. A Country of Publication: Switzerland NLM ID: 101642264 Publication Model: eCollection Cited Medium: Print ISSN: 2296-861X (Print) Linking ISSN: 2296861X NLM ISO Abbreviation: Front Nutr Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Media S. A., [2014]-
مستخلص: Background and Aims: We evaluated adipose tissue-derived hormones, body composition, serum metabolic profile, levels of brain-derived neurotrophic factor (BDNF), and the association of these parameters with the clinical outcome in patients with COVID-19. We sought to examine whether obesity, sex, and age influence the adipose tissue endocrine response to the disease. Methods: This prospective study investigated 145 hospitalized patients with COVID-19. Patients were categorized based on their body mass index (BMI), sex and age, and were also classified regarding their outcome after hospitalization as: (a) Non-ICU: patients hospitalized who did not receive intensive care; (b) ICU-survivor: patients admitted to the intensive care unit and discharged; (c) ICU-death: patients who died. Blood samples were collected by the hospital staff between the first and third day of hospitalization. Serum leptin, adiponectin and BDNF concentrations, triglycerides, total cholesterol and cholesterol fractions were performed following the manufacturer's guidelines. Results: We demonstrate that BDNF levels predict intensive care (IC) need ( p < 0.01). This association was found to be stronger in patients >60y ( p = 0.026). Neither leptin nor adiponectin concentration was associated with IC requirement or with patient's outcome, while the BDNF/adiponectin ratio was closely associated with worsened outcomes ( p < 0.01). BDNF concentration was similar between sexes, however tended to be lower in male patients ( p = 0.023). In older patients, BDNF concentration was lower than that of younger patients ( p = 0.020). These age and sex-specific differences should be considered when employing these potential markers for prognosis assessment. While appetite and body composition regulating hormones secreted by the white adipose tissue are not reliable predictors of disease severity, the ratio BDNF/adiponectin was indicative of patient status. Conclusion: Thus, we propose that serum BDNF content and BDNF/adiponectin ratio may serve as tools predicting worsened prognosis in COVID-19, especially for male patients.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2021 Minuzzi, Seelaender, Silva, Cunha, Deus, Vasconcellos, Marqueze, Gadotti, Baena, Pereira, Krüger, Amaral, Pinho and Lira.)
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فهرسة مساهمة: Keywords: BDNF; COVID-19 severity; adiponectin; adipose tissue hormones; leptin
تواريخ الأحداث: Date Created: 20211227 Latest Revision: 20211228
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8704131
DOI: 10.3389/fnut.2021.784429
PMID: 34957187
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-861X
DOI:10.3389/fnut.2021.784429