دورية أكاديمية
أعرض في EDS

Changes in Circulating Metabolites during Weight Loss and Weight Loss Maintenance in Relation to Cardiometabolic Risk.

التفاصيل البيبلوغرافية
العنوان: Changes in Circulating Metabolites during Weight Loss and Weight Loss Maintenance in Relation to Cardiometabolic Risk.
المؤلفون: Papandreou C; Institute of Health Pere Virgili, IISPV, University Hospital Sant Joan, 43204 Reus, Spain.; Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, Rovira i Virgili University, 43201 Reus, Spain., Harrold JA; Department of Psychology, Institute of Population Health, University of Liverpool, Liverpool L69 3GL, UK., Hansen TT; Department of Nutrition, Exercise and Sports, Section for Obesity Research, University of Copenhagen, 2200 Copenhagen, Denmark., Halford JCG; School of Psychology, University of Leeds, Leeds LS2 9JT, UK., Sjödin A; Department of Nutrition, Exercise and Sports, Section for Obesity Research, University of Copenhagen, 2200 Copenhagen, Denmark., Bulló M; Institute of Health Pere Virgili, IISPV, University Hospital Sant Joan, 43204 Reus, Spain.; Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, Rovira i Virgili University, 43201 Reus, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain.
المصدر: Nutrients [Nutrients] 2021 Nov 27; Vol. 13 (12). Date of Electronic Publication: 2021 Nov 27.
نوع المنشور: Journal Article; Multicenter Study; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Caloric Restriction*, Body Weight Maintenance/*physiology , Obesity/*diet therapy , Obesity/*physiopathology , Weight Loss/*physiology, Adult ; Aged ; Body Mass Index ; Cardiometabolic Risk Factors ; Cholesterol/blood ; Cholesterol, LDL/blood ; Female ; Humans ; Linear Models ; Male ; Middle Aged ; Obesity/blood ; Phosphatidylcholines/blood ; Prospective Studies ; Satiation ; Sphingomyelins/blood ; Triglycerides/blood ; Valine/blood ; Young Adult
مستخلص: (1) Background: There is a substantial lack of knowledge of the biochemical mechanisms by which weight loss and weight regain exert their beneficial and adverse effects, respectively, on cardiometabolic outcomes. We examined associations between changes in circulating metabolites and changes in cardiometabolic risk factors during diet-induced weight loss and weight loss maintenance. (2) Methods: This prospective analysis of data from the Satiety Innovation (SATIN) study involved adults living with overweight and obesity (mean age=47.5). One hundred sixty-two subjects achieving ≥8% weight loss during an initial 8-week low-calorie diet (LCD) were included in a 12-week weight loss maintenance period. Circulating metabolites (m=123) were profiled using a targeted multiplatform approach. Data were analyzed using multivariate linear regression models. (3) Results: Decreases in the concentrations of several phosphatidylcholines (PCs), sphingomyelins (SMs), and valine were consistently associated with decreases in total (TChol) and low-density lipoprotein cholesterol (LDL-C) levels during the LCD. Increases in PCs and SMs were significantly associated with increases in TChol and LDL-C during the weight loss maintenance period. Decreases and increases in PCs during LCD and maintenance period, respectively, were associated with decreases in the levels of triglycerides. (4) Conclusions: The results of this study suggest that decreases in circulating PCs and SMs during weight loss and the subsequent weight loss maintenance period may decrease the cardiovascular risk through impacting TChol and LDL-C.
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فهرسة مساهمة: Keywords: SATIN; cardiometabolic risk; metabolomics; weight loss; weight maintenance
المشرفين على المادة: 0 (Cholesterol, LDL)
0 (Phosphatidylcholines)
0 (Sphingomyelins)
0 (Triglycerides)
97C5T2UQ7J (Cholesterol)
HG18B9YRS7 (Valine)
تواريخ الأحداث: Date Created: 20211228 Date Completed: 20220119 Latest Revision: 20220119
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC8708084
DOI: 10.3390/nu13124289
PMID: 34959840
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu13124289