دورية أكاديمية
أعرض في EDS

Iron Related Biomarkers Predict Disease Severity in a Cohort of Portuguese Adult Patients during COVID-19 Acute Infection.

التفاصيل البيبلوغرافية
العنوان: Iron Related Biomarkers Predict Disease Severity in a Cohort of Portuguese Adult Patients during COVID-19 Acute Infection.
المؤلفون: Moreira AC; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.; ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal., Teles MJ; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; CHUSJ-Centro Hospitalar Universitário São João, 4200-319 Porto, Portugal.; ISPUP-EPIUnit-Instituto de Saúde Pública da Universidade do Porto, 4050-091 Porto, Portugal., Silva T; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.; ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal., Bento CM; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.; MCBiology-Programa Doutoral em Biologia Molecular e Celular, Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, 4200-135 Porto, Portugal., Alves IS; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal., Pereira L; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; IPATIMUP-Instituto de Patologia e Imunologia Molecular da Universidade do Porto, 4200-135 Porto, Portugal., Guimarães JT; CHUSJ-Centro Hospitalar Universitário São João, 4200-319 Porto, Portugal.; ISPUP-EPIUnit-Instituto de Saúde Pública da Universidade do Porto, 4050-091 Porto, Portugal.; FMUP-Faculdade de Medicina da Universidade do Porto, 4200-319 Porto, Portugal., Porto G; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.; ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal.; CHPorto-Centro Hospitalar do Porto, 4099-001 Porto, Portugal., Oliveira P; ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal.; ISPUP-EPIUnit-Instituto de Saúde Pública da Universidade do Porto, 4050-091 Porto, Portugal., Gomes MS; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.; ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal.
المصدر: Viruses [Viruses] 2021 Dec 10; Vol. 13 (12). Date of Electronic Publication: 2021 Dec 10.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: COVID-19* , Severity of Illness Index*, Biomarkers/*blood , Iron/*blood, Adult ; Aged ; Aged, 80 and over ; Chemokine CCL2/blood ; Cohort Studies ; Cytokines/blood ; Female ; Ferritins ; Hepcidins ; Humans ; Inflammation ; Interleukin-6/blood ; Male ; Middle Aged ; Portugal ; SARS-CoV-2
مستخلص: Large variability in COVID-19 clinical progression urges the need to find the most relevant biomarkers to predict patients' outcomes. We evaluated iron metabolism and immune response in 303 patients admitted to the main hospital of the northern region of Portugal with variable clinical pictures, from September to November 2020. One hundred and twenty-seven tested positive for SARS-CoV-2 and 176 tested negative. Iron-related laboratory parameters and cytokines were determined in blood samples collected soon after admission. Demographic data, comorbidities and clinical outcomes were recorded. Patients were assigned into five groups according to severity. Serum iron and transferrin levels at admission were lower in COVID-19-positive than in COVID-19-negative patients. The levels of interleukin (IL)-6 and monocyte chemoattractant protein 1 (MCP-1) were increased in COVID-19-positive patients. The lowest serum iron and transferrin levels at diagnosis were associated with the worst outcomes. Iron levels negatively correlated with IL-6 and higher levels of this cytokine were associated with a worse prognosis. Serum ferritin levels at diagnosis were higher in COVID-19-positive than in COVID-19-negative patients. Serum iron is the simplest laboratory test to be implemented as a predictor of disease progression in COVID-19-positive patients.
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معلومات مُعتمدة: Research4COVID-grant 569 Fundação para a Ciência e Tecnologia
فهرسة مساهمة: Keywords: COVID-19; SARS-CoV-2; ferritin; hepcidin; hypoferremia of inflammation; interleukin-6; iron; macrophage chemoattractant protein-1
المشرفين على المادة: 0 (Biomarkers)
0 (CCL2 protein, human)
0 (Chemokine CCL2)
0 (Cytokines)
0 (Hepcidins)
0 (Interleukin-6)
9007-73-2 (Ferritins)
E1UOL152H7 (Iron)
تواريخ الأحداث: Date Created: 20211228 Date Completed: 20220118 Latest Revision: 20220118
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8703662
DOI: 10.3390/v13122482
PMID: 34960751
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4915
DOI:10.3390/v13122482