دورية أكاديمية
Optical Membrane Control with Red Light Enabled by Red-Shifted Photolipids.
العنوان: | Optical Membrane Control with Red Light Enabled by Red-Shifted Photolipids. |
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المؤلفون: | Pritzl SD; Chair for Photonics and Optoelectronics, Nano-Institute Munich, Department of Physics, Ludwig-Maximilians-Universtität (LMU), Königinstraße 10, 80539 Munich, Germany., Konrad DB; Department of Pharmacy, Ludwig-Maximilians-Universtität (LMU), Butenandtstraße 5-13, 81377 Munich, Germany., Ober MF; Faculty of Physics and CeNS, Ludwig-Maximilians-Universtität (LMU), Geschwister-Scholl-Platz 1, 80539 München, Germany., Richter AF; Chair for Photonics and Optoelectronics, Nano-Institute Munich, Department of Physics, Ludwig-Maximilians-Universtität (LMU), Königinstraße 10, 80539 Munich, Germany., Frank JA; Department of Chemical Physiology & Biochemistry, Vollum Institute, Oregon, Health & Science University, 3181 S.W. Sam Jackson Park Rd., Portland, Oregon 97239, United States., Nickel B; Faculty of Physics and CeNS, Ludwig-Maximilians-Universtität (LMU), Geschwister-Scholl-Platz 1, 80539 München, Germany., Trauner D; Department of Chemistry, New York University, Silver Center, 100 Washington Square East, Room 712, New York, New York 10003, United States., Lohmüller T; Chair for Photonics and Optoelectronics, Nano-Institute Munich, Department of Physics, Ludwig-Maximilians-Universtität (LMU), Königinstraße 10, 80539 Munich, Germany. |
المصدر: | Langmuir : the ACS journal of surfaces and colloids [Langmuir] 2022 Jan 11; Vol. 38 (1), pp. 385-393. Date of Electronic Publication: 2021 Dec 31. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
اللغة: | English |
بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9882736 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5827 (Electronic) Linking ISSN: 07437463 NLM ISO Abbreviation: Langmuir Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Washington, DC : American Chemical Society, c1985- |
مواضيع طبية MeSH: | Light* , Phosphatidylcholines*, Azo Compounds ; Lipid Bilayers ; Liposomes ; Phospholipids |
مستخلص: | Photoswitchable phospholipids, or "photolipids", that harbor an azobenzene group in their lipid tails are versatile tools to manipulate and control lipid bilayer properties with light. So far, the limited ultraviolet-A/blue spectral range in which the photoisomerization of regular azobenzene operates has been a major obstacle for biophysical or photopharmaceutical applications. Here, we report on the synthesis of nano- and micrometer-sized liposomes from tetra- ortho -chloro azobenzene-substituted phosphatidylcholine (termed red - azo - PC ) that undergoes photoisomerization on irradiation with tissue-penetrating red light (≥630 nm). Photoswitching strongly affects the fluidity and mechanical properties of lipid membranes, although small-angle X-ray scattering and dynamic light scattering measurements reveal only a minor influence on the overall bilayer thickness and area expansion. By controlling the photostationary state and the photoswitching efficiency of red - azo - PC for specific wavelengths, we demonstrate that shape transitions such as budding or pearling and the division of cell-sized vesicles can be achieved. These results emphasize the applicability of red - azo - PC as a nanophotonic tool in synthetic biology and for biomedical applications. |
المشرفين على المادة: | 0 (Azo Compounds) 0 (Lipid Bilayers) 0 (Liposomes) 0 (Phosphatidylcholines) 0 (Phospholipids) |
تواريخ الأحداث: | Date Created: 20211231 Date Completed: 20220201 Latest Revision: 20220201 |
رمز التحديث: | 20221213 |
DOI: | 10.1021/acs.langmuir.1c02745 |
PMID: | 34969246 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1520-5827 |
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DOI: | 10.1021/acs.langmuir.1c02745 |