دورية أكاديمية
أعرض في EDS

Comparison of the Efficiency of Lepidium sativum , Ficus carica , and Punica granatum Methanolic Extracts in Relieving Hyperglycemia and Hyperlipidemia of Streptozotocin-Induced Diabetic Rats.

التفاصيل البيبلوغرافية
العنوان: Comparison of the Efficiency of Lepidium sativum , Ficus carica , and Punica granatum Methanolic Extracts in Relieving Hyperglycemia and Hyperlipidemia of Streptozotocin-Induced Diabetic Rats.
المؤلفون: Ramadan S; Department of Industrial Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Sadat City, Egypt., Hegab AM; Developmental Pharmacology Department, The National Organization for Drug Control and Research (NODCAR), Egypt., Al-Awthan YS; Department of Biology, Faculty of Science, University of Tabuk, 71491 Tabuk, Saudi Arabia., Al-Duais MA; Biochemistry Department, Faculty of Science, University of Tabuk, 71491 Tabuk, Saudi Arabia., Tayel AA; Faculty of Aquatic and Fisheries Sciences, Kafrelsheikh University, Egypt., Al-Saman MA; Department of Industrial Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Sadat City, Egypt.
المصدر: Journal of diabetes research [J Diabetes Res] 2021 Dec 21; Vol. 2021, pp. 6018835. Date of Electronic Publication: 2021 Dec 21 (Print Publication: 2021).
نوع المنشور: Comparative Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Limited Country of Publication: England NLM ID: 101605237 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6753 (Electronic) NLM ISO Abbreviation: J Diabetes Res Subsets: MEDLINE
أسماء مطبوعة: Publication: <2019>-: London, United Kingdom : Hindawi Limited
Original Publication: Nasr City, Cairo : Hindawi Publishing Corporation, [2013]-
مواضيع طبية MeSH: Ficus*/chemistry , Lepidium sativum*/chemistry , Pomegranate*/chemistry, Blood Glucose/*drug effects , Diabetes Mellitus, Experimental/*drug therapy , Hyperlipidemias/*drug therapy , Hypoglycemic Agents/*pharmacology , Hypolipidemic Agents/*pharmacology , Lipids/*blood , Plant Extracts/*pharmacology, Animals ; Biomarkers/blood ; Blood Glucose/metabolism ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/chemically induced ; Glycated Hemoglobin/metabolism ; Hyperlipidemias/blood ; Hyperlipidemias/chemically induced ; Hypoglycemic Agents/isolation & purification ; Hypolipidemic Agents/isolation & purification ; Male ; Plant Extracts/isolation & purification ; Rats ; Streptozocin
مستخلص: Background: Diabetes mellitus (DM) is a metabolic disorder characterized by high blood glucose levels that occurs either due to insufficient insulin production or mounting resistance to its action. The purpose of this study was to investigate if methanolic extracts of Lepidium sativum seeds, Ficus carica , and Punica granatum leaves had any effect on blood sugar levels in normal and streptozotocin (STZ) diabetic rats, as well as to explore the most effective extract.
Method: Healthy male albino rats weighing 185-266 g were divided into nine groups of eight rats each: normal control, diabetic control, diabetic rats with dietary supplements of L. sativum , F. carica , and P. granatum methanolic extracts, and diabetics treated with insulin. All of the rats were fed on ordinary diet with nutritional pellets and were given water ad libitum . To induce diabetes, all animals were administered with STZ intraperitoneal injection at a dose of 60 mg/kg body weight. For five weeks, the crude plant extracts were given orally to various groups of rats at doses of one hundred and two hundred mg/kg body weight. After that, animal groups were sacrificed and blood samples were taken.
Results: Phytochemical analysis revealed that the highest amounts of polyphenolic compounds were present in L. sativum seeds and P. granatum leaves, while leaves of F. carica showed the highest amounts of alkaloid and flavonoid content compared to other extracts. Oral administration of F. carica and L. sativum extracts at the dosage of 100 and 200 mg/kg significantly reduced glucose, lipid profile, kidney, and liver enzyme levels. A significant increase in HbAlc levels was also observed with L. sativum extract at a dose of 200 mg/kg compared to diabetic controls. Mellitus rats supplemented with 100 and 200 mg/kg methanolic extracts of P. granatum had higher serum triglycerides and lower serum low-density lipoprotein cholesterol (LDL-C) than normal control rats. F. carica extract is more effective than L. sativum and P. granatum extracts in the prevention and control of type 2 diabetes mellitus (T2DM) and its consequences.
Competing Interests: The authors declare that there are no conflicts of interest.
(Copyright © 2021 Shimaa Ramadan et al.)
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المشرفين على المادة: 0 (Biomarkers)
0 (Blood Glucose)
0 (Glycated Hemoglobin A)
0 (Hypoglycemic Agents)
0 (Hypolipidemic Agents)
0 (Lipids)
0 (Plant Extracts)
5W494URQ81 (Streptozocin)
تواريخ الأحداث: Date Created: 20211231 Date Completed: 20220321 Latest Revision: 20231108
رمز التحديث: 20231108
مُعرف محوري في PubMed: PMC8714380
DOI: 10.1155/2021/6018835
PMID: 34970629
قاعدة البيانات: MEDLINE
الوصف
تدمد:2314-6753
DOI:10.1155/2021/6018835