دورية أكاديمية
أعرض في EDS

Crosstalk relationship between adiponectin receptors, PPAR-γ and α-adrenoceptors in renal vasculature of diabetic WKYs.

التفاصيل البيبلوغرافية
العنوان: Crosstalk relationship between adiponectin receptors, PPAR-γ and α-adrenoceptors in renal vasculature of diabetic WKYs.
المؤلفون: Afzal S; School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, MAHSA University, Selangor, Malaysia. Electronic address: samalik77@hotmail.com., Sattar MA; School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia., Eseyin OA; Faculty of Pharmacy, University of Uyo, Uyo, Akwa Ibom State, Nigeria. Electronic address: olorunfemieseyin.pharm.lect@uniuyo.edu.ng., Attiq A; Department of Pharmacology and Toxicology, Faculty of Pharmacy, MAHSA University, Selangor, Malaysia. Electronic address: aliattiqbutt@gmail.com., Johns EJ; Department of Physiology, University College Cork, Cork, Ireland.
المصدر: European journal of pharmacology [Eur J Pharmacol] 2022 Feb 15; Vol. 917, pp. 174703. Date of Electronic Publication: 2021 Dec 31.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol
أسماء مطبوعة: Publication: 2005- : Amsterdam : Elsevier Science
Original Publication: Amsterdam, North Holland Pub. Co.
مواضيع طبية MeSH: PPAR gamma*/agonists , PPAR gamma*/metabolism , Rats, Inbred WKY* , Kidney*/drug effects , Kidney*/metabolism , Kidney*/blood supply , Pioglitazone*/pharmacology , Irbesartan*/pharmacology , Diabetes Mellitus, Experimental*/metabolism , Diabetes Mellitus, Experimental*/drug therapy , Biphenyl Compounds*/pharmacology , Biphenyl Compounds*/therapeutic use , Receptors, Adiponectin*/metabolism , Receptors, Adiponectin*/agonists , Receptors, Adrenergic, alpha*/metabolism, Animals ; Male ; Rats ; Adiponectin/metabolism ; Receptor Cross-Talk/drug effects ; Tetrazoles/pharmacology ; Thiazolidinediones/pharmacology ; Angiotensin II/pharmacology ; Vasoconstriction/drug effects
مستخلص: Hypoadiponectinemia is associated with renal dysfunctions. Irbesartan and pioglitazone activate Peroxisome proliferator-activated gamma receptor (PPAR-γ) as partial and full agonists. We investigated a crosstalk interaction and synergistic action between adiponectin receptors, PPAR-γ agonists in attenuating renal hemodynamics to adrenergic agonists in diabetic Wistar Kyoto rats (WKY). Streptozotocin (40 mg/kg) was used to induce diabetes, whereas, pioglitazone (10 mg/kg/day), irbesartan (30 mg/kg/day) administered orally for 28 days and adiponectin intraperitoneally (2.5 μg/kg/day) for last 7 days. Metabolic and plasma samples were analyzed on days 0, 8, 21, and 28. During the acute study (day 29), renal vasoconstrictor actions to adrenergic agonists and angiotensin-II were determined. Diabetic WKYs had lower plasma adiponectin, higher creatinine clearance, urinary and fractional sodium excretion but were normalized to a greater extent in pioglitazone and adiponectin combined treatment. Responses to intra-renal administration of adrenergic agonists including noradrenaline (NA), phenylephrine (PE), methoxamine (ME), and angiotensin-II (ANG-II) were larger in diabetic WKY, but significantly blunted with adiponectin treatment in diabetic WKYs to 35-40%, and further reduced by 65-70% in combination with pioglitazone. Attenuation to ANG-II responses in adiponectin and combination with irbesartan was 30-35% and 75-80%, respectively (P < 0.05). Pharmacodynamically, a crosstalk interaction exists between PPAR-γ, adiponectin receptors (adipo R1 & R2), alpha adrenoceptors, and angiotensin-I (ATI) receptors in the renal vasculature of diabetic WKYs. Exogenously administered adiponectin with full PPAR-γ agonist substantially attenuated renal hemodynamics and improved excretory functions, signifying their renoprotective action. Additionally, a degree of synergism exists between adiponectin and pioglitazone to a large extent compared to combination therapy with irbesartan (partial PPAR-γ agonist) in attenuating the renal vascular receptiveness to adrenergic agonists.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Adiponectin; Alpha adrenoceptors; Ang-II; Diabetes; PPAR-γ; Wistar kyoto rats
المشرفين على المادة: 0 (PPAR gamma)
X4OV71U42S (Pioglitazone)
J0E2756Z7N (Irbesartan)
0 (Biphenyl Compounds)
0 (Receptors, Adiponectin)
0 (Receptors, Adrenergic, alpha)
0 (Adiponectin)
0 (Tetrazoles)
0 (Thiazolidinediones)
11128-99-7 (Angiotensin II)
تواريخ الأحداث: Date Created: 20220102 Date Completed: 20240724 Latest Revision: 20240724
رمز التحديث: 20240726
DOI: 10.1016/j.ejphar.2021.174703
PMID: 34973951
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0712
DOI:10.1016/j.ejphar.2021.174703