دورية أكاديمية
Fecal microbiome profiles of neonatal dairy calves with varying severities of gastrointestinal disease.
العنوان: | Fecal microbiome profiles of neonatal dairy calves with varying severities of gastrointestinal disease. |
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المؤلفون: | Slanzon GS; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America., Ridenhour BJ; Department of Mathematics and Statistical Science, College of Science, University of Idaho, Moscow, Idaho, United States of America., Moore DA; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America., Sischo WM; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America., Parrish LM; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America., Trombetta SC; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America., McConnel CS; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America. |
المصدر: | PloS one [PLoS One] 2022 Jan 04; Vol. 17 (1), pp. e0262317. Date of Electronic Publication: 2022 Jan 04 (Print Publication: 2022). |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
اللغة: | English |
بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
مواضيع طبية MeSH: | Bacteria/*isolation & purification , Bacterial Infections/*complications , Cattle Diseases/*pathology , Feces/*microbiology , Gastrointestinal Diseases/*pathology , Gastrointestinal Diseases/*veterinary, Animals ; Animals, Newborn ; Bacteria/classification ; Bacteria/pathogenicity ; Bacterial Infections/microbiology ; Cattle ; Cattle Diseases/microbiology ; Gastrointestinal Diseases/microbiology |
مستخلص: | Gastrointestinal disease (GI) is the most common illness in pre-weaned dairy calves. Studies have associated the fecal microbiome composition with health status, but it remains unclear how the microbiome changes across different levels of GI disease and breeds. Our objective was to associate the clinical symptoms of GI disease with the fecal microbiome. Fecal samples were collected from calves (n = 167) of different breeds (Holstein, Jersey, Jersey-cross and beef-cross) from 4-21 d of age. Daily clinical evaluations assessed health status. Calves with loose or watery feces were diagnosed with diarrhea and classified as bright-sick (BS) or depressed-sick (DS) according to behavior. Calves with normal or semiformed feces and no clinical illness were classified as healthy (H). One hundred and three fecal samples were obtained from consistently healthy calves and 64 samples were from calves with diarrhea (n = 39 BS; n = 25 DS). The V3-V4 region of 16S rRNA gene was sequenced and analyzed. Differences were identified by a linear-mixed effects model with a negative binomial error. DS and Jersey calves had a higher relative abundance of Streptococcus gallolyticus relative to H Holstein calves. In addition, DS calves had a lower relative abundance of Bifidobacterium longum and an enrichment of Escherichia coli. Species of the genus Lactobacillus, such as an unclassified Lactobacillus, Lactobacillus reuteri, and Lactobacillus salivarius were enriched in calves with GI disease. Moreover, we created a model to predict GI disease based on the fecal microbiome composition. The presence of Eggerthella lenta, Bifidobacterium longum, and Collinsella aerofaciens were associated with a healthy clinical outcome. Although lactobacilli are often associated with beneficial probiotic properties, the presence of E. coli and Lactobacillus species had the highest coefficients positively associated with GI disease prediction. Our results indicate that there are differences in the fecal microbiome of calves associated with GI disease severity and breed specificities. Competing Interests: The authors have declared that no competing interests exist. |
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تواريخ الأحداث: | Date Created: 20220104 Date Completed: 20220221 Latest Revision: 20240405 |
رمز التحديث: | 20240405 |
مُعرف محوري في PubMed: | PMC8726473 |
DOI: | 10.1371/journal.pone.0262317 |
PMID: | 34982792 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1932-6203 |
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DOI: | 10.1371/journal.pone.0262317 |