دورية أكاديمية
Antinociceptive Effects of Aza-Bicyclic Isoxazoline-Acylhydrazone Derivatives in Different Models of Nociception in Mice.
| العنوان: | Antinociceptive Effects of Aza-Bicyclic Isoxazoline-Acylhydrazone Derivatives in Different Models of Nociception in Mice. |
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| المؤلفون: | Mota FVB; Department of Antibiotics, Federal University of Pernambuco (UFPE), Recife-PE, Brazil., Coutinho FN; Department of Pharmaceutical Sciences, Federal University of Pernambuco (UFPE), Recife-PE, Brazil., de Carvalho VMF; Department of Antibiotics, Federal University of Pernambuco (UFPE), Recife-PE, Brazil., de Assis Correia JC; Department of Antibiotics, Federal University of Pernambuco (UFPE), Recife-PE, Brazil., Bastos IVGA; Department of Antibiotics, Federal University of Pernambuco (UFPE), Recife-PE, Brazil., Marcelino-Neto PP; Department of Antibiotics, Federal University of Pernambuco (UFPE), Recife-PE, Brazil., Ximenes RM; Department of Antibiotics, Federal University of Pernambuco (UFPE), Recife-PE, Brazil., Brondani DJ; Department of Pharmaceutical Sciences, Federal University of Pernambuco (UFPE), Recife-PE, Brazil., de Faria AR; Department of Pharmaceutical Sciences, Federal University of Pernambuco (UFPE), Recife-PE, Brazil., Marchand P; Nantes Université, Cibles et Médicaments des Infections et de l\'Immunité, IICiMed, UR 1155, F-44000 Nantes, France., da Silva TG; Department of Antibiotics, Federal University of Pernambuco (UFPE), Recife-PE, Brazil. |
| المصدر: | Current topics in medicinal chemistry [Curr Top Med Chem] 2022 Mar 04; Vol. 22 (4), pp. 247-258. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101119673 Publication Model: Print Cited Medium: Internet ISSN: 1873-4294 (Electronic) Linking ISSN: 15680266 NLM ISO Abbreviation: Curr Top Med Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Saif Zone, Sharjah, U.A.E. : Bentham Science Publishers Original Publication: Hilversum, The Netherlands : Bentham Science Publishers, c2001- |
| مواضيع طبية MeSH: | Analgesics*/pharmacology , Analgesics*/therapeutic use , Nociception*, Analgesics, Opioid/adverse effects ; Animals ; Mice ; Pain/drug therapy ; Plant Extracts/chemistry |
| مستخلص: | Background: In a study recently published by our research group, the isoxazoline-acylhydrazone derivatives R-99 and R-123 presented promising antinociceptive activity. However, the mechanism of action of this compound is still unknown. Objective: This study aimed to assess the mechanisms involved in the antinociceptive activity of these compounds in chemical models of pain. Methods: Animals were orally pretreated and evaluated in the acetic acid-, formalin-, capsaicin-, carrageenan- and Complete Freund's Adjuvant (CFA)-induced pain models in mice. The effects of the compounds after pretreatment with naloxone, prazosin, yohimbine, atropine, L-arginine, or glibenclamide were studied, using the acetic acid-induced writhing test to verify the possible involvement of opioid, α1-adrenergic, α2-adrenergic or cholinergic receptors, and nitric oxide or potassium channels pathways, respectively. Results: R-99 and R-123 compounds showed significant antinociceptive activity on pain models induced by acetic acid, formalin, and capsaicin. Both compounds decreased the mechanical hyperalgesia induced by carrageenan or CFA in mice. The antinociceptive effects of R-99 and R-123 on the acetic acid-induced writhing test were significantly attenuated by pretreatment with naloxone, yohimbine or atropine. R-99 also showed an attenuated response after pretreatment with atropine and glibenclamide. However, on the pretreatment with prazosin, there was no change in the animals' response to both compounds. Conclusion: R-99 and R-123 showed antinociceptive effects related to mechanisms that involve, at least in part, interaction with the opioid and adrenergic systems and TRPV1 pathways. The compound R-99 also interacts with the cholinergic pathways and potassium channels. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| معلومات مُعتمدة: | 470901/2014-4 Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq |
| فهرسة مساهمة: | Keywords: Adrenergic system; Hyperalgesia; Opioid; Pain; Potassium channels; Receptors |
| المشرفين على المادة: | 0 (Analgesics) 0 (Analgesics, Opioid) 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20220106 Date Completed: 20220317 Latest Revision: 20220317 |
| رمز التحديث: | 20240628 |
| DOI: | 10.2174/1568026622666220105102508 |
| PMID: | 34986770 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1873-4294 |
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| DOI: | 10.2174/1568026622666220105102508 |