دورية أكاديمية
أعرض في EDS

Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro and in vivo biofilm.

التفاصيل البيبلوغرافية
العنوان: Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro and in vivo biofilm.
المؤلفون: de Vor L; Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands., van Dijk B; Department of Orthopedics, University Medical Centre Utrecht, Utrecht, Netherlands., van Kessel K; Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands., Kavanaugh JS; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States., de Haas C; Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands., Aerts PC; Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands., Viveen MC; Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands., Boel EC; Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands., Fluit AC; Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands., Kwiecinski JM; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States., Krijger GC; Department of Radiology and Nuclear Medicine, University Medical Centre Utrecht, Utrecht, Netherlands., Ramakers RM; MILabs B.V, Utrecht, Netherlands.; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center, Utrecht, Netherlands.; Department of Radiation Science and Technology, Delft University of Technology, Delft, Netherlands., Beekman FJ; MILabs B.V, Utrecht, Netherlands.; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center, Utrecht, Netherlands.; Department of Radiation Science and Technology, Delft University of Technology, Delft, Netherlands., Dadachova E; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada., Lam MG; Department of Radiology and Nuclear Medicine, University Medical Centre Utrecht, Utrecht, Netherlands., Vogely HC; Department of Orthopedics, University Medical Centre Utrecht, Utrecht, Netherlands., van der Wal BC; Department of Orthopedics, University Medical Centre Utrecht, Utrecht, Netherlands., van Strijp JA; Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands., Horswill AR; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, United States.; Department of Veterans Affairs, Eastern Colorado Health Care System, Denver, United States., Weinans H; Department of Orthopedics, University Medical Centre Utrecht, Utrecht, Netherlands.; Department of Biomechanical engineering, TU Delft, Delft, Netherlands., Rooijakkers SH; Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands.
المصدر: ELife [Elife] 2022 Jan 06; Vol. 11. Date of Electronic Publication: 2022 Jan 06.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Biofilms*, Antibodies, Monoclonal/*immunology , Antibodies, Monoclonal/*metabolism , Staphylococcus aureus/*immunology, Animals ; Catheter-Related Infections/immunology ; Catheter-Related Infections/microbiology ; Catheter-Related Infections/therapy ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Staphylococcal Infections/microbiology ; Teichoic Acids/immunology ; Teichoic Acids/metabolism
مستخلص: Implant-associated Staphylococcus aureus infections are difficult to treat because of biofilm formation. Bacteria in a biofilm are often insensitive to antibiotics and host immunity. Monoclonal antibodies (mAbs) could provide an alternative approach to improve the diagnosis and potential treatment of biofilm-related infections. Here, we show that mAbs targeting common surface components of S. aureus can recognize clinically relevant biofilm types. The mAbs were also shown to bind a collection of clinical isolates derived from different biofilm-associated infections (endocarditis, prosthetic joint, catheter). We identify two groups of antibodies: one group that uniquely binds S. aureus in biofilm state and one that recognizes S. aureus in both biofilm and planktonic state. Furthermore, we show that a mAb recognizing wall teichoic acid (clone 4497) specifically localizes to a subcutaneously implanted pre-colonized catheter in mice. In conclusion, we demonstrate the capacity of several human mAbs to detect S. aureus biofilms in vitro and in vivo.
Competing Interests: Ld, Bv, Kv, JK, Cd, PA, MV, EB, AF, JK, GK, ED, ML, HV, Bv, Jv, AH, HW, SR No competing interests declared, RR Ruud M. Ramakers has stock appreciation rights at MILabs B.V, FB Freek J. Beekman is shareholder at MILabs B.V
(© 2022, de Vor et al.)
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معلومات مُعتمدة: P01 AI083211 United States AI NIAID NIH HHS; I01 BX002711 United States BX BLRD VA
فهرسة مساهمة: Keywords: Staphylococcus aureus; biofilm; infectious disease; microbiology; monoclonal antibodies
سلسلة جزيئية: Dryad 10.5061/dryad.vmcvdncs2
المشرفين على المادة: 0 (Antibodies, Monoclonal)
0 (Teichoic Acids)
تواريخ الأحداث: Date Created: 20220106 Date Completed: 20220302 Latest Revision: 20240405
رمز التحديث: 20240405
مُعرف محوري في PubMed: PMC8751199
DOI: 10.7554/eLife.67301
PMID: 34989676
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.67301