دورية أكاديمية
MPTP produces a mosaic-like pattern of terminal degeneration in the caudate nucleus of dog.
| العنوان: | MPTP produces a mosaic-like pattern of terminal degeneration in the caudate nucleus of dog. |
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| المؤلفون: | Wilson JS; Department of Anatomy, School of Medicine, Howard University, Washington, DC 20059., Turner BH, Morrow GD, Hartman PJ |
| المصدر: | Brain research [Brain Res] 1987 Oct 13; Vol. 423 (1-2), pp. 329-32. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print Cited Medium: Print ISSN: 0006-8993 (Print) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Nerve Degeneration*, Caudate Nucleus/*pathology , Pyridines/*toxicity, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Animals ; Caudate Nucleus/drug effects ; Dogs ; Male ; Putamen/drug effects ; Putamen/pathology |
| مستخلص: | This paper describes the spatial pattern of terminal degeneration in the caudate nucleus and putamen of the dog following an injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Marked inhomogeneities in the filed of terminal degeneration were found in the head of the caudate nucleus, which are reminiscent of the fundamental patch/matrix organization of the striatum. Using MPTP as a selective lesioning method, our results provide further evidence that the dopaminergic, nigrostriatal projection has a heterogeneous organization. |
| معلومات مُعتمدة: | 2S06 RR08016-16 United States RR NCRR NIH HHS |
| المشرفين على المادة: | 0 (Pyridines) 9P21XSP91P (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) |
| تواريخ الأحداث: | Date Created: 19871013 Date Completed: 19871222 Latest Revision: 20190614 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/0006-8993(87)90857-2 |
| PMID: | 3499959 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0006-8993 |
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| DOI: | 10.1016/0006-8993(87)90857-2 |