دورية أكاديمية
EEG as a Functional Marker of Nicotine Activity: Evidence From a Pilot Study of Adults With Late-Life Depression.
| العنوان: | EEG as a Functional Marker of Nicotine Activity: Evidence From a Pilot Study of Adults With Late-Life Depression. |
|---|---|
| المؤلفون: | Conley AC; Department of Psychiatry, Center for Cognitive Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Key AP; Department of Psychiatry, Center for Cognitive Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Vanderbilt Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN, United States., Taylor WD; Department of Psychiatry, Center for Cognitive Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Veterans Affairs Medical Center, Geriatric Research, Education and Clinical Center, Tennessee Valley Healthcare System, Nashville, TN, United States., Albert KM; Department of Psychiatry, Center for Cognitive Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Boyd BD; Department of Psychiatry, Center for Cognitive Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Vega JN; Department of Psychiatry, Center for Cognitive Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Newhouse PA; Department of Psychiatry, Center for Cognitive Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.; Department of Veterans Affairs Medical Center, Geriatric Research, Education and Clinical Center, Tennessee Valley Healthcare System, Nashville, TN, United States. |
| المصدر: | Frontiers in psychiatry [Front Psychiatry] 2021 Dec 23; Vol. 12, pp. 721874. Date of Electronic Publication: 2021 Dec 23 (Print Publication: 2021). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101545006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-0640 (Print) Linking ISSN: 16640640 NLM ISO Abbreviation: Front Psychiatry Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Switzerland : Frontiers Research Foundation, 2010- |
| مستخلص: | Late-life depression (LLD) is a debilitating condition that is associated with poor response to antidepressant medications and deficits in cognitive performance. Nicotinic cholinergic stimulation has emerged as a potentially effective candidate to improve cognitive performance in patients with cognitive impairment. Previous studies of nicotinic stimulation in animal models and human populations with cognitive impairment led to examining potential cognitive and mood effects of nicotinic stimulation in older adults with LLD. We report results from a pilot study of transdermal nicotine in LLD testing whether nicotine treatment would enhance cognitive performance and mood. The study used electroencephalography (EEG) recordings as a tool to test for potential mechanisms underlying the effect of nicotine. Eight non-smoking participants with LLD completed EEG recordings at baseline and after 12 weeks of transdermal nicotine treatment (NCT02816138). Nicotine augmentation treatment was associated with improved performance on an auditory oddball task. Analysis of event-related oscillations showed that nicotine treatment was associated with reduced beta desynchronization at week 12 for both standard and target trials. The change in beta power on standard trials was also correlated with improvement in mood symptoms. This pilot study provides preliminary evidence for the impact of nicotine in modulating cortical activity and improving mood in depressed older adults and shows the utility of using EEG as a marker of functional engagement in nicotinic interventions in clinical geriatric patients. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Conley, Key, Taylor, Albert, Boyd, Vega and Newhouse.) |
| References: | Neurosci Biobehav Rev. 2017 Jul;78:178-191. (PMID: 28445740) J Clin Psychiatry. 2018 Aug 28;79(5):. (PMID: 30192444) J Neurosci. 2006 Jan 11;26(2):435-9. (PMID: 16407540) Hum Brain Mapp. 2019 Aug 15;40(12):3657-3668. (PMID: 31081231) Clin Pharmacol Ther. 1994 Apr;55(4):370-7. (PMID: 8162662) Med Care. 1986 Jan;24(1):67-74. (PMID: 3945130) Pharmacol Biochem Behav. 1999 Jun;63(2):253-61. (PMID: 10371654) J Neurosci Methods. 2004 Mar 15;134(1):9-21. (PMID: 15102499) Psychopharmacology Suppl. 1984;1:58-68. (PMID: 6382255) Curr Opin Neurobiol. 2004 Apr;14(2):212-7. (PMID: 15082327) Transl Psychiatry. 2019 Nov 7;9(1):279. (PMID: 31699968) Biol Psychiatry. 1998 Jul 1;44(1):34-46. (PMID: 9646881) J Affect Disord. 2011 Jan;128(1-2):41-8. (PMID: 20619899) Curr Opin Pharmacol. 2004 Feb;4(1):36-46. (PMID: 15018837) Arch Gen Psychiatry. 2010 Mar;67(3):277-85. (PMID: 20194828) Ann N Y Acad Sci. 2001 Jun;931:359-75. (PMID: 11462753) Front Aging Neurosci. 2014 Nov 07;6:301. (PMID: 25426065) J Psychopharmacol. 2011 Feb;25(2):239-48. (PMID: 19939874) Int J Psychophysiol. 2012 Dec;86(3):195-205. (PMID: 22580156) Psychopharmacology (Berl). 1999 Feb;142(2):193-9. (PMID: 10102772) Psychiatry Res. 2010 Aug 30;179(1):30-7. (PMID: 20630603) Neurosci Lett. 2014 Aug 8;577:6-10. (PMID: 24905171) Hum Brain Mapp. 2009 Feb;30(2):602-14. (PMID: 18181154) Neuropsychopharmacology. 2004 Dec;29(12):2278-84. (PMID: 15340393) Neuroreport. 2002 Jul 2;13(9):1097-106. (PMID: 12151749) Z Gerontol Geriatr. 2018 Feb;51(2):200-205. (PMID: 27422260) J Psychiatr Res. 2018 Feb;97:1-7. (PMID: 29156413) Neuropsychology. 2021 Feb;35(2):232-240. (PMID: 33764113) J Addict Med. 2011 Jun;5(2):123-33. (PMID: 21769058) Am J Geriatr Psychiatry. 2008 Jul;16(7):558-67. (PMID: 18591576) Neuroimage. 2016 May 15;132:499-511. (PMID: 26975557) Neuropsychology. 2006 Jul;20(4):420-9. (PMID: 16846260) Brain Res Rev. 2011 Jun 24;67(1-2):331-43. (PMID: 21592583) Trends Cogn Sci. 2012 Dec;16(12):606-17. (PMID: 23141428) Clin Neurophysiol. 1999 Jan;110(1):24-30. (PMID: 10348317) Comput Intell Neurosci. 2011;2011:156869. (PMID: 21253357) Neurobiol Aging. 2014 Jan;35(1):247-53. (PMID: 23993703) Acta Psychiatr Scand. 2016 Jul;134(1):73-82. (PMID: 27037665) Int Rev Psychiatry. 2013 Oct;25(5):604-18. (PMID: 24151805) Psychopharmacology (Berl). 1998 Nov;140(2):135-41. (PMID: 9860103) J Neurosci. 2014 May 7;34(19):6634-9. (PMID: 24806688) Psychopharmacology (Berl). 1999 Aug;145(3):342-50. (PMID: 10494584) Neuropsychologia. 2017 May;99:81-91. (PMID: 28254653) Neuropsychologia. 2010 May;48(6):1862-8. (PMID: 20176041) Sci Rep. 2020 Nov 5;10(1):19179. (PMID: 33154495) Neurology. 2006 Sep 12;67(5):834-42. (PMID: 16966547) Neuroimage. 2015 Mar;108:354-63. (PMID: 25528657) Clin Neurophysiol. 2007 Oct;118(10):2128-48. (PMID: 17573239) Br J Psychiatry. 1979 Apr;134:382-9. (PMID: 444788) Clin Neurophysiol. 2006 Feb;117(2):369-80. (PMID: 16356768) Neural Netw. 2000 May-Jun;13(4-5):411-30. (PMID: 10946390) Psychopharmacology (Berl). 2006 Nov;189(1):125-33. (PMID: 16977477) JAMA Psychiatry. 2015 Jun;72(6):603-11. (PMID: 25785575) Neurosci Biobehav Rev. 2019 Jul;102:371-381. (PMID: 31047891) BMC Psychiatry. 2020 Mar 4;20(1):102. (PMID: 32131786) Psychol Med. 2020 Oct;50(13):2203-2212. (PMID: 31477195) Neurology. 2012 Jan 10;78(2):91-101. (PMID: 22232050) Neurosci Biobehav Rev. 2018 Jan;84:289-298. (PMID: 28859996) Neuropsychologia. 2007 Mar 2;45(4):617-29. (PMID: 16962146) Trends Pharmacol Sci. 2010 Dec;31(12):580-6. (PMID: 20965579) Psychiatry Res. 2015 Mar 30;226(1):169-72. (PMID: 25639374) Nicotine Tob Res. 2002 May;4(2):185-94. (PMID: 12028851) Psychophysiology. 2013 Jun;50(6):583-93. (PMID: 23517339) J Am Geriatr Soc. 2005 Apr;53(4):695-9. (PMID: 15817019) Neuron. 2002 Oct 24;36(3):539-48. (PMID: 12408855) Soc Personal Psychol Compass. 2008 Sep 1;2(5):1824-1843. (PMID: 25067943) J Psychopharmacol. 2011 Sep;25(9):1175-91. (PMID: 21106608) Brain Res Rev. 2007 Jan;53(1):63-88. (PMID: 16887192) Brain Topogr. 1996 Summer;8(4):355-66. (PMID: 8813415) J Affect Disord. 2002 May;69(1-3):241-9. (PMID: 12103473) Neurobiol Aging. 2018 Nov;71:149-155. (PMID: 30144647) Psychogeriatrics. 2010 Sep;10(3):138-43. (PMID: 20860569) Neuropsychologia. 2014 Sep;62:403-23. (PMID: 25068705) Soc Cogn Affect Neurosci. 2017 Jul 1;12(7):1159-1168. (PMID: 28460035) Am J Geriatr Psychiatry. 2011 Feb;19(2):115-22. (PMID: 20808124) Brain Struct Funct. 2017 Nov;222(8):3665-3676. (PMID: 28417233) Elife. 2019 Nov 29;8:. (PMID: 31782732) Front Hum Neurosci. 2016 Mar 30;10:116. (PMID: 27065830) Int Psychogeriatr. 2011 Feb;23(1):141-8. (PMID: 20561385) Clin Neurophysiol. 2012 Feb;123(2):278-84. (PMID: 21798799) N Engl J Med. 2014 Sep 25;371(13):1228-36. (PMID: 25251617) Int J Psychophysiol. 2015 Sep;97(3):189-209. (PMID: 25920962) Int J Psychophysiol. 2013 Sep;89(3):334-41. (PMID: 23688673) Brain Res. 2012 May 15;1454:14-22. (PMID: 22483790) Front Psychol. 2011 Apr 26;2:73. (PMID: 21687444) Front Aging Neurosci. 2013 Dec 27;5:100. (PMID: 24409145) Int J Psychophysiol. 2008 Jan;67(1):1-16. (PMID: 17963912) Biol Psychiatry. 2006 Jul 1;60(1):58-65. (PMID: 16414031) Pharmacol Biochem Behav. 2014 Jul;122:107-17. (PMID: 24690514) |
| معلومات مُعتمدة: | P50 HD103537 United States HD NICHD NIH HHS |
| فهرسة مساهمة: | Keywords: EEG; beta power; event-related oscillations; late-life depression; nicotine |
| تواريخ الأحداث: | Date Created: 20220110 Latest Revision: 20230212 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8732868 |
| DOI: | 10.3389/fpsyt.2021.721874 |
| PMID: | 35002791 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-0640 |
|---|---|
| DOI: | 10.3389/fpsyt.2021.721874 |