دورية أكاديمية
أعرض في EDS

Intensive Medical Nutrition Therapy Alone or with Added Metformin to Prevent Gestational Diabetes Mellitus among High-Risk Mexican Women: A Randomized Clinical Trial.

التفاصيل البيبلوغرافية
العنوان: Intensive Medical Nutrition Therapy Alone or with Added Metformin to Prevent Gestational Diabetes Mellitus among High-Risk Mexican Women: A Randomized Clinical Trial.
المؤلفون: Perichart-Perera O; Department of Nutrition and Bioprogramming, Instituto Nacional de Perinatología 'Isidro Espinosa de los Reyes', Montes Urales 800, Mexico City 11000, Mexico., Mier-Cabrera J; Departamento de Salud, Universidad Iberoamericana, Ciudad de México, Prolongación Paseo de la Reforma 880, Mexico City 01219, Mexico., Flores-Robles CM; Department of Endocrinology, Instituto Nacional de Perinatología 'Isidro Espinosa de los Reyes', Montes Urales 800, Mexico City 11000, Mexico., Martínez-Cruz N; Department of Endocrinology, Instituto Nacional de Perinatología 'Isidro Espinosa de los Reyes', Montes Urales 800, Mexico City 11000, Mexico., Arce-Sánchez L; Department of Endocrinology, Instituto Nacional de Perinatología 'Isidro Espinosa de los Reyes', Montes Urales 800, Mexico City 11000, Mexico., Alvarado-Maldonado IN; Department of Endocrinology, Instituto Nacional de Perinatología 'Isidro Espinosa de los Reyes', Montes Urales 800, Mexico City 11000, Mexico., Montoya-Estrada A; Coordination of Gynecological and Perinatal Endocrinology, Instituto Nacional de Perinatología 'Isidro Espinosa de los Reyes', Montes Urales 800, Mexico City 11000, Mexico., Romo-Yañez J; Coordination of Gynecological and Perinatal Endocrinology, Instituto Nacional de Perinatología 'Isidro Espinosa de los Reyes', Montes Urales 800, Mexico City 11000, Mexico., Rodríguez-Cano AM; Department of Nutrition and Bioprogramming, Instituto Nacional de Perinatología 'Isidro Espinosa de los Reyes', Montes Urales 800, Mexico City 11000, Mexico., Estrada-Gutierrez G; Research Direction, Instituto Nacional de Perinatología, 'Isidro Espinosa de los Reyes', Montes Urales 800, Mexico City 11000, Mexico., Espino Y Sosa S; Clinical Research Branch, Instituto Nacional de Perinatología 'Isidro Espinosa de los Reyes', Montes Urales 800, Mexico City 11000, Mexico., Guzmán-Huerta M; Department of Translational Medicine, Instituto Nacional de Perinatología 'Isidro Espinosa de los Reyes', Montes Urales 800, Mexico City 11000, Mexico., Ayala-Yañez R; Direction of Centro de Investigación Materno Infantil del Grupo de Estudios al Nacimiento, CIMIGEN, Avenida Tlahuac 1004, Mexico City 09890, Mexico.; Deparment of Gynecologist and Obstetrics, Centro Medico ABC, Avenida Carlos Graef Fernández 154, Mexico City 05300, Mexico., Reyes-Muñoz E; Coordination of Gynecological and Perinatal Endocrinology, Instituto Nacional de Perinatología 'Isidro Espinosa de los Reyes', Montes Urales 800, Mexico City 11000, Mexico.
المصدر: Nutrients [Nutrients] 2021 Dec 24; Vol. 14 (1). Date of Electronic Publication: 2021 Dec 24.
نوع المنشور: Clinical Trial, Phase IV; Journal Article; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Diabetes, Gestational/*prevention & control , Hypoglycemic Agents/*administration & dosage , Metformin/*administration & dosage , Nutrition Therapy/*methods , Pregnancy Complications/*prevention & control, Adolescent ; Adult ; Body Mass Index ; Female ; Humans ; Hypoglycemic Agents/therapeutic use ; Infant, Newborn ; Maternal Age ; Medical History Taking ; Mexico ; Middle Aged ; Pregnancy ; Young Adult
مستخلص: The aim of this study was to examine the efficacy of intensive medical nutrition therapy (MNT) plus metformin in preventing gestational diabetes mellitus (GDM) among high-risk Mexican women. An open-label randomized clinical trial was conducted. Inclusion criteria were pregnant women with three or more GDM risk factors: Latino ethnic group, maternal age >35 years, body mass index >25 kg/m 2 , insulin resistance, and a history of previous GDM, prediabetes, a macrosomic neonate, polycystic ovarian syndrome, or a first-degree relative with type 2 diabetes. Women before 15 weeks of gestation were assigned to group 1 ( n = 45): intensive MNT-plus metformin (850 mg twice/day) or group 2 ( n = 45): intensive MNT without metformin. Intensive MNT included individual dietary counseling, with ≤50% of total energy from high carbohydrates. The primary outcome was the GDM incidence according to the International Association of Diabetes Pregnancy Study Groups criteria. There were no significant differences in baseline characteristics and adverse perinatal outcomes between the groups. The GDM incidence was n = 11 (24.4%) in the MNT plus metformin group versus n = 7 (15.5%) in the MNT without metformin group: p = 0.42 (RR: 1.57 [95% CI: 0.67-3.68]). There is no benefit in adding metformin to intensive MNT to prevent GDM among high-risk Mexican women. Clinical trials registration: NCT01675310.
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معلومات مُعتمدة: 151819 Consejo Nacional de Ciencia y Tecnología; 212250-42131 Instituto Nacional de Perinatología
فهرسة مساهمة: Keywords: diet; gestational diabetes; gestational weight gain; obesity; pregnancy
سلسلة جزيئية: ClinicalTrials.gov NCT01675310
المشرفين على المادة: 0 (Hypoglycemic Agents)
9100L32L2N (Metformin)
تواريخ الأحداث: Date Created: 20220111 Date Completed: 20220121 Latest Revision: 20220121
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8746971
DOI: 10.3390/nu14010062
PMID: 35010938
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu14010062