دورية أكاديمية
أعرض في EDS

Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection.

التفاصيل البيبلوغرافية
العنوان: Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection.
المؤلفون: Rizvi ZA; Immuno-biology Lab, Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India.; Immunology Core, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India., Dalal R; Immuno-biology Lab, Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India., Sadhu S; Immuno-biology Lab, Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India., Binayke A; Immuno-biology Lab, Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India., Dandotiya J; Immuno-biology Lab, Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India., Kumar Y; Non-communicable Disease Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India., Shrivastava T; Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India., Gupta SK; Non-communicable Disease Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India., Aggarwal S; Non-communicable Disease Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India., Tripathy MR; Immuno-biology Lab, Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India., Rathore DK; Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India., Yadav AK; Non-communicable Disease Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India., Medigeshi GR; Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India., Pandey AK; Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India., Samal S; Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India., Asthana S; Non-communicable Disease Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India., Awasthi A; Immuno-biology Lab, Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India.; Immunology Core, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India.
المصدر: ELife [Elife] 2022 Jan 11; Vol. 11. Date of Electronic Publication: 2022 Jan 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: COVID-19*/blood , COVID-19*/complications , COVID-19*/pathology , Cardiovascular Diseases*/blood , Cardiovascular Diseases*/etiology , Cardiovascular Diseases*/pathology , Cardiovascular Diseases*/virology, SARS-CoV-2/*metabolism, Animals ; Cholesterol/blood ; Disease Models, Animal ; Female ; Humans ; Lipoproteins, LDL/blood ; Mesocricetus ; Triglycerides/blood ; Troponin I/blood
مستخلص: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in the Golden Syrian hamster causes lung pathology that resembles human coronavirus disease (COVID-19). However, extrapulmonary pathologies associated with SARS-CoV-2 infection and post-COVID sequelae remain to be understood. Here, we show, using a hamster model, that the early phase of SARS-CoV-2 infection leads to an acute inflammatory response and lung pathologies, while the late phase of infection causes cardiovascular complications (CVCs) characterized by ventricular wall thickening associated with increased ventricular mass/body mass ratio and interstitial coronary fibrosis. Molecular profiling further substantiated our findings of CVC as SARS-CoV-2-infected hamsters showed elevated levels of serum cardiac troponin I, cholesterol, low-density lipoprotein, and long-chain fatty acid triglycerides. Serum metabolomics profiling of SARS-CoV-2-infected hamsters identified N-acetylneuraminate, a functional metabolite found to be associated with CVC, as a metabolic marker was found to be common between SARS-CoV-2-infected hamsters and COVID-19 patients. Together, we propose hamsters as a suitable animal model to study post-COVID sequelae associated with CVC, which could be extended to therapeutic interventions.
Competing Interests: ZR, RD, SS, AB, JD, YK, TS, SG, SA, MT, DR, AY, GM, AP, SS, SA, AA No competing interests declared
(© 2022, Rizvi et al.)
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فهرسة مساهمة: Keywords: SARS-CoV2; cardiovascular; hamster; infectious disease; microbiology
سلسلة جزيئية: Dryad 10.5061/dryad.vhhmgqnvt
المشرفين على المادة: 0 (Lipoproteins, LDL)
0 (Triglycerides)
0 (Troponin I)
97C5T2UQ7J (Cholesterol)
تواريخ الأحداث: Date Created: 20220111 Date Completed: 20220201 Latest Revision: 20220201
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8794466
DOI: 10.7554/eLife.73522
PMID: 35014610
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.73522