دورية أكاديمية
Tacrolimus intrapatient variability in BK virus nephropathy and chronic calcineurin toxicity in kidney transplantation.
| العنوان: | Tacrolimus intrapatient variability in BK virus nephropathy and chronic calcineurin toxicity in kidney transplantation. |
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| المؤلفون: | Turgut D; Department of Internal Medicine, Division of Nephrology, Baskent University Ankara Hospital, Ankara, Turkey., Sayin B; Department of Internal Medicine, Division of Nephrology, Baskent University Ankara Hospital, Ankara, Turkey., Soy EA; Department of General Surgery, Division of Transplantation, Baskent University Ankara Hospital, Ankara, Turkey., Topcu Dİ; Department of Biochemistry, Baskent University Ankara Hospital, Ankara, Turkey., Ozdemir BH; Department of Pathology, Baskent University Ankara Hospital, Ankara, Turkey., Haberal M; Department of General Surgery, Division of Transplantation, Baskent University Ankara Hospital, Ankara, Turkey. |
| المصدر: | Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia [Saudi J Kidney Dis Transpl] 2021 Mar-Apr; Vol. 32 (2), pp. 348-354. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medknow Country of Publication: Saudi Arabia NLM ID: 9436968 Publication Model: Print Cited Medium: Internet ISSN: 1319-2442 (Print) Linking ISSN: 13192442 NLM ISO Abbreviation: Saudi J Kidney Dis Transpl Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2007- : Mumbai : Medknow Original Publication: Riyadh : Saudi Center for Organ Transplantation, c1994- |
| مواضيع طبية MeSH: | Kidney Transplantation*/adverse effects, BK Virus/*isolation & purification , Calcineurin/*adverse effects , Immunosuppressive Agents/*adverse effects , Kidney Diseases/*chemically induced , Polyomavirus Infections/*complications , Tacrolimus/*adverse effects , Tumor Virus Infections/*complications , Tumor Virus Infections/*epidemiology, Adult ; Aged ; Calcineurin/therapeutic use ; Case-Control Studies ; Female ; Graft Rejection/epidemiology ; Graft Rejection/prevention & control ; Graft Survival ; Humans ; Immunosuppressive Agents/therapeutic use ; Kidney/pathology ; Kidney Diseases/diagnosis ; Kidney Diseases/epidemiology ; Kidney Diseases/surgery ; Kidney Failure, Chronic/surgery ; Male ; Middle Aged ; Nephritis, Interstitial ; Postoperative Complications/virology ; Retrospective Studies ; Risk Factors ; Tacrolimus/therapeutic use ; Treatment Outcome ; Tumor Virus Infections/virology |
| مستخلص: | Intrapatient variability (IPV) in tacrolimus has been increasingly acknowledged as a risk factor for poor graft survival after kidney transplantation. Although past studies have mainly accounted for IPV in acute or chronic rejection states as due to underimmunosuppression, this is not yet clear. So far, tacrolimus IPV for BK virus-associated nephropathy (BKVN) and chronic calcineurin inhibitor toxicity (CNIT) has not been investigated. Here, we evaluated IPV in tacrolimus for BKVN and chronic CNIT, which are mainly considered as overimmunosuppression states. In this case-control study, kidney allograft biopsies conducted between 1998 and 2018 were included, with patients grouped by biopsy results as BKVN alone group, CNIT alone group, and normal graft function (control group). IPV was estimated as mean absolute deviation. Our study groups included 25 kidney transplant recipients with BKVN alone, 91 patients with CNIT alone, and 60 patients with normal 5-year graft survival (control group). In analyses of IPV in tacrolimus six months before graft biopsy, IPV was highest in the BKVN group (P = 0.001). The BKVN group also had the highest IPV in tacrolimus at 12 months after biopsy (P = 0.001), with all pairwise comparisons statistically different between groups. At 12 months after biopsy, five patients (20%) in the BKVN group and 10 patients (10.9%) in the CNIT group had graft loss. Among other risk factors, BKVN and chronic CNIT are consequences related to high IPV. Quantification of IVP for tacrolimus in clinical practice would help to optimize kidney transplant outcomes. |
| التعليقات: | Comment in: Exp Clin Transplant. 2023 Jan;21(1):22-27. (PMID: 36757165) |
| المشرفين على المادة: | 0 (Immunosuppressive Agents) EC 3.1.3.16 (Calcineurin) WM0HAQ4WNM (Tacrolimus) |
| تواريخ الأحداث: | Date Created: 20220112 Date Completed: 20220207 Latest Revision: 20230509 |
| رمز التحديث: | 20231215 |
| DOI: | 10.4103/1319-2442.335446 |
| PMID: | 35017328 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1319-2442 |
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| DOI: | 10.4103/1319-2442.335446 |