دورية أكاديمية
أعرض في EDS

Comparative Evaluation of Antibacterial Property of Bioactive Glass Alone and its Combination with Chlorhexidine against Enterococcus faecalis - An In vitro Study.

التفاصيل البيبلوغرافية
العنوان: Comparative Evaluation of Antibacterial Property of Bioactive Glass Alone and its Combination with Chlorhexidine against Enterococcus faecalis - An In vitro Study.
المؤلفون: Soumya S; Department of Conservative Dentistry and Endodontics, Noorul Islam College of Dental Sciences, Thiruvananthapuram, Kerala, India., Gaffoor MAF; Department of Conservative Dentistry and Endodontics, Noorul Islam College of Dental Sciences, Thiruvananthapuram, Kerala, India., Samuel A; Department of Conservative Dentistry and Endodontics, Noorul Islam College of Dental Sciences, Thiruvananthapuram, Kerala, India., Gopakumar R; Department of Conservative Dentistry and Endodontics, Noorul Islam College of Dental Sciences, Thiruvananthapuram, Kerala, India., Girish CS; Department of Conservative Dentistry and Endodontics, Noorul Islam College of Dental Sciences, Thiruvananthapuram, Kerala, India., Sajeena NC; Department of Conservative Dentistry and Endodontics, Noorul Islam College of Dental Sciences, Thiruvananthapuram, Kerala, India.
المصدر: Journal of pharmacy & bioallied sciences [J Pharm Bioallied Sci] 2021 Nov; Vol. 13 (Suppl 2), pp. S1448-S1451. Date of Electronic Publication: 2021 Nov 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Medknow Publications Country of Publication: India NLM ID: 101537209 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0976-4879 (Print) Linking ISSN: 09757406 NLM ISO Abbreviation: J Pharm Bioallied Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Mumbai, India : Medknow Publications
مستخلص: Context: One of the most common organisms responsible for root canal failure even after the usage of intracanal medicament is Enterococcus faecalis . Newer medicaments with higher antibacterial efficacy against E. faecalis need to be analyzed.
Aim: The aim of this study was to compare the antibacterial property of bioactive glass (BAG) alone and its combination with chlorhexidine (CHX) against E. faecalis .
Materials and Methods: Eighty permanent maxillary single-rooted teeth were included in the study. These teeth were randomly divided into three groups of ten teeth each. Dentin blocks were prepared. After debris and smear layer removal, dentin blocks were inoculated with E. faecalis and incubated for 7 days for biofilm formation. Medications including BAG alone and combination of CHX with BAG were placed into the dentin blocks and incubated at 37°C for 72 h. Dentinal shavings were collected, and the mean bacterial count was recorded.
Statistical Analysis: The comparison of colony-forming unit (CFU) counts was done using one-way analysis of variance, Tukey's post hoc test, and unpaired t -test. The analysis was done using the Statistical Package for the Social Sciences version 20.0 for Windows.
Results: Based on the CFU count obtained after 72 h, compared to the control group, both Group 1 and Group 2 reduced the bacterial load effectively. In comparison with Group 1, Group 2 (combination) was found to be more effective against E. faecalis .
Conclusion: It can be concluded that although BAG was effective against E. faecalis , its efficacy increased significantly in combination with CHX.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2021 Journal of Pharmacy and Bioallied Sciences.)
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فهرسة مساهمة: Keywords: Antimicrobial; Enterococcus faecalis; bioactive glass; chlorhexidine; combination
تواريخ الأحداث: Date Created: 20220112 Latest Revision: 20220430
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8686953
DOI: 10.4103/jpbs.jpbs_249_21
PMID: 35018007
قاعدة البيانات: MEDLINE
الوصف
تدمد:0976-4879
DOI:10.4103/jpbs.jpbs_249_21