دورية أكاديمية
Coagulation profile of human COVID-19 convalescent plasma.
| العنوان: | Coagulation profile of human COVID-19 convalescent plasma. |
|---|---|
| المؤلفون: | Klompas AM; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., van Helmond N; Department of Anesthesiology, Cooper Medical School of Rowan University, Cooper University Health Care, Camden, NJ, USA., Juskewitch JE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Pruthi RK; Division of Hematology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Sexton MA; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Soto JCD; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Klassen SA; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Senese KA; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., van Buskirk CM; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Winters JL; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Stubbs JR; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Hammel SA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Joyner MJ; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Senefeld JW; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. senefeld.jonathon@mayo.edu. |
| المصدر: | Scientific reports [Sci Rep] 2022 Jan 12; Vol. 12 (1), pp. 637. Date of Electronic Publication: 2022 Jan 12. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
| مواضيع طبية MeSH: | Blood Coagulation*, COVID-19/*blood , COVID-19/*therapy, Adult ; Blood Coagulation Tests ; Blood Preservation ; Blood Transfusion ; Female ; Humans ; Immunization, Passive ; Male ; Middle Aged ; COVID-19 Serotherapy |
| مستخلص: | Convalescent plasma is used to treat COVID-19. There are theoretical concerns about the impact of pro-coagulant factors in convalescent plasma on the coagulation cascade particularly among patients with severe COVID-19. The aim of this study was to evaluate the coagulation profile of COVID-19 convalescent plasma. Clotting times and coagulation factor assays were compared between fresh frozen plasma, COVID-19 convalescent plasma, and pathogen-reduced COVID-19 convalescent plasma. Measurements included prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen, D-dimer, von Willebrand factor activity, von Willebrand factor antigen, coagulation factors II, V, VII-XII, protein S activity, protein C antigen, and alpha-2 plasmin inhibitor. Clotting times and coagulation factor assays were not different between COVID-19 convalescent plasma and fresh frozen plasma, except for protein C antigen. When compared to fresh frozen plasma and regular convalescent plasma, pathogen reduction treatment increased activated partial thromboplastin time and thrombin time, while reducing fibrinogen, coagulation factor II, V, VIII, IX, X, XI, XII, protein S activity, and alpha-2 plasmin inhibitor. The coagulation profiles of human COVID-19 convalescent plasma and standard fresh frozen plasma are not different. Pathogen reduced COVID-19 convalescent plasma is associated with reduction of coagulation factors and a slight prolongation of coagulation times, as anticipated. A key limitation of the study is that the COVID-19 disease course of the convalesced donors was not characterized. (© 2022. The Author(s).) |
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| معلومات مُعتمدة: | F32 HL154320 United States HL NHLBI NIH HHS; R35 HL139854 United States HL NHLBI NIH HHS; 5R35HL139854 United States HL NHLBI NIH HHS; F32HL154320 United States HL NHLBI NIH HHS |
| تواريخ الأحداث: | Date Created: 20220113 Date Completed: 20220126 Latest Revision: 20240214 |
| رمز التحديث: | 20240214 |
| مُعرف محوري في PubMed: | PMC8755772 |
| DOI: | 10.1038/s41598-021-04670-1 |
| PMID: | 35022488 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2045-2322 |
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| DOI: | 10.1038/s41598-021-04670-1 |